Results 21 to 30 of about 15,244 (279)

Osteoporosis remission via an anti-inflammaging effect by icariin activated autophagy

Biomaterials, 2023
The pace of bone formation slows down with aging, which leads to the development of osteoporosis. In addition to senescent bone marrow mesenchymal stem cells (S-BMSCs), senescent macrophages (S-MΦs) present in the bone marrow produce numerous ...
Chen, Peiru, Xiaohui Zhang, Zhang, Xiaohui, Xiao, Yin, Peiru Chen, Changsheng Liu, Liu, Changsheng, Yanpeng Liu, Jing Wang, Ruiqiang Hang, Wang, Jing, Yin Xiao, Long Bai, Bai, Long, Hang, Ruiqiang, Liu, Yanpeng   +15 more
core   +2 more sources

Tryptophan Metabolism in Inflammaging: From Biomarker to Therapeutic Target [PDF]

Frontiers in Immunology, 2019
Inflammation aims to restore tissue homeostasis after injury or infection. Age-related decline of tissue homeostasis causes a physiological low-grade chronic inflammatory phenotype known as inflammaging that is involved in many age-related diseases ...
Freek J. H. Sorgdrager, Freek J. H. Sorgdrager, Freek J. H. Sorgdrager, Freek J. H. Sorgdrager, Petrus J. W. Naudé, Petrus J. W. Naudé, Ido P. Kema, Ellen A. Nollen, Peter P. De Deyn, Peter P. De Deyn, Peter P. De Deyn   +10 more
doaj   +2 more sources

Identification of crucial inflammaging related risk factors in multiple sclerosis [PDF]

Frontiers in Molecular Neuroscience
BackgroundMultiple sclerosis (MS) is an immune-mediated disease characterized by inflammatory demyelinating lesions in the central nervous system. Studies have shown that the inflammation is vital to both the onset and progression of MS, where aging ...
Mengchu Xu, Huize Wang, Siwei Ren, Bing Wang, Wenyan Yang, Ling Lv, Xianzheng Sha, Wenya Li, Yin Wang, Yin Wang   +9 more
doaj   +2 more sources

Inflammaging and Brain Aging

International Journal of Molecular Sciences
Progress made by the medical community in increasing lifespans comes with the costs of increasing the incidence and prevalence of age-related diseases, neurodegenerative ones included.
M. Jurcau, Anamaria Jurcău, Alexander Cristian, Vlad Octavian Hogea, R. Diaconu, V. Nunkoo   +5 more
semanticscholar   +3 more sources

Inflammaging as a target for healthy ageing

Age and Ageing, 2023
Life expectancy has been on the rise for the past few decades, but healthy life expectancy has not kept pace, leading to a global burden of age-associated disorders.
Conway, Jessica; id_orcid, Duggal, Niharika A; id_orcid, Dugan, Ben   +2 more
core   +2 more sources

A brake on inflammaging

Science Translational Medicine, 2020
Metformin reverses an aging-associated inflammatory immune profile. Age is a major risk factor for many life-threatening diseases including cardiometabolic disease, cancer, and neurodegeneration.
Van den Bossche, J
core   +2 more sources

A narrative review on inflammaging and late-onset hypogonadism [PDF]

Frontiers in Endocrinology
The increasing life expectancy observed in recent years has resulted in a higher prevalence of late-onset hypogonadism (LOH) in older men. LOH is characterized by the decline in testosterone levels and can have significant impacts on physical and mental ...
Dong Xing, Yihan Jin, Baofang Jin
doaj   +2 more sources

Nonuniversality of inflammaging across human populations

Nature Aging
National audienceInflammaging, an age-associated increase in chronic inflammation, is considered a hallmark of aging. However, there is no consensus approach to measuring inflammaging based on circulating cytokines.
Fülöp, Tamàs, Pawelec, Graham, Kraft, Thomas S., Lea, Amanda J., Ho, Roger C., Mehrjerd, Ameneh, Aronoff, Jacob E., Sheng Yeong, Joe Poh, Gurven, Michael, Charalambous, Eleftheria G., Tanner, Kamaryn T., Aiello, Allison E., Venkataraman, Vivek, Lemoine, Maël, Kaplan, Hillard, Ferrucci, Luigi, Lim, Yvonne A.L., Cohen, Alan A., Hertel, Johannes, Franceschi, Claudio, Bandinelli, Stefania, Ng, Kee Seong, Trumble, Benjamin C., Stieglitz, Jonathan, Lim, Xinru, Franck, Maximilien, Wallace, Ian J., Daunizeau, Camille, Tennyson, Robert L.   +28 more
core   +2 more sources

T cell control of inflammaging

Seminars in Immunology, 2023
T cells are a critical component of the immune system, found in abundance in blood, secondary lymphoid organs, and peripheral tissues. As individuals age, T cells are particularly susceptible to changes, making them one of the most affected immune ...
Pavla Bohacova, Irina Shchukina, Shchukina, Irina, Bohacova, Pavla, Maxim N. Artyomov, Artyomov, Maxim N   +5 more
core   +4 more sources

Pathogenesis and inflammaging in myelodysplastic syndrome

Haematologica
Myelodysplastic syndromes (MDS) are a genetically complex and phenotypically diverse set of clonal hematologic neoplasms that occur with increasing frequency with age.
Matthew T. Villaume, Michael R. Savona
doaj   +3 more sources