Results 21 to 30 of about 14,164 (239)

Inflammaging and Osteoarthritis

Clinical Reviews in Allergy & Immunology, 2022
Osteoarthritis is a highly prevalent disease particularly in subjects over 65 years of age worldwide. While in the past it was considered a mere consequence of cartilage degradation leading to anatomical and functional joint impairment, in recent decades, there has been a more dynamic view with the synovium, the cartilage, and the subchondral bone ...
Francesca Motta, Elisa Barone, Antonio Sica, Carlo Selmi   +3 more
openaire   +4 more sources

Inflammaging and the Lung [PDF]

Clinics in Geriatric Medicine, 2017
With the coming of the "silver tsunami," expanding the knowledge about how various intrinsic and extrinsic factors affect the immune system in the elderly is timely and of immediate clinical need. The global population is increasing in age. By the year 2030, more than 20% of the population of the United States will be older than 65 years of age.
Elizabeth J, Kovacs, Devin M, Boe, Lisbeth A, Boule, Brenda J, Curtis   +3 more
openaire   +2 more sources

Inflammaging and Osteoarthritis. [PDF]

, 2023
Osteoarthritis is a highly prevalent disease particularly in subjects over 65 years of age worldwide. While in the past it was considered a mere consequence of cartilage degradation leading to anatomical and functional joint impairment, in recent decades,
Antonio Sica
core   +1 more source

Immunology of Aging: the Birth of Inflammaging [PDF]

Clinical Reviews in Allergy & Immunology, 2021
The inflammaging concept was introduced in 2000 by Prof. Franceschi. This was an evolutionary or rather a revolutionary conceptualization of the immune changes in response to a lifelong stress. This conceptualization permitted to consider the lifelong proinflammatory process as an adaptation which could eventually lead to either beneficial or ...
T. Fulop, A. Larbi, G. Pawelec, A. Khalil, A. A. Cohen, K. Hirokawa, J. M. Witkowski, C. Franceschi   +7 more
openaire   +2 more sources

Inflammaging: Experimental Insights and Translational Advances. [PDF]

Eur J Immunol
Inflammaging, defined as the persistent, low‐grade sterile inflammation accompanying aging, represents a central driver of age‐related pathology, including cardiovascular dysfunction, neurodegeneration, metabolic disorders, and frailty.
Cossarizza A.
europepmc   +2 more sources

Alzheimer’s Disease and Inflammaging

Brain Sciences, 2022
Alzheimer’s disease is one of the most common age-related neurodegenerative disorders. The main theory of Alzheimer’s disease progress is the amyloid-β cascade hypothesis. However, the initial mechanisms of insoluble forms of amyloid-β formation and hyperphosphorylated tau protein in neurons remain unclear.
Anna Kosyreva, Alexandra Sentyabreva, Ivan Tsvetkov, Olga Makarova   +3 more
openaire   +3 more sources

Inflammaging: Implications in Sarcopenia

International Journal of Molecular Sciences, 2022
In a world in which life expectancy is increasing, understanding and promoting healthy aging becomes a contemporary demand. In the elderly, a sterile, chronic and low-grade systemic inflammation known as “inflammaging” is linked with many age-associated diseases. Considering sarcopenia as a loss of strength and mass of skeletal muscle related to aging,
Eduardo Antuña, Cristina Cachán-Vega, Juan Carlos Bermejo-Millo, Yaiza Potes, Beatriz Caballero, Ignacio Vega-Naredo, Ana Coto-Montes, Claudia Garcia-Gonzalez   +7 more
openaire   +4 more sources

Osteoporosis remission via an anti-inflammaging effect by icariin activated autophagy

, 2023
The pace of bone formation slows down with aging, which leads to the development of osteoporosis. In addition to senescent bone marrow mesenchymal stem cells (S-BMSCs), senescent macrophages (S-MΦs) present in the bone marrow produce numerous ...
Chen, Peiru, Xiaohui Zhang, Zhang, Xiaohui, Xiao, Yin, Peiru Chen, Changsheng Liu, Liu, Changsheng, Yanpeng Liu, Jing Wang, Ruiqiang Hang, Wang, Jing, Yin Xiao, Long Bai, Bai, Long, Hang, Ruiqiang, Liu, Yanpeng   +15 more
core   +1 more source

Understanding how we age: insights into inflammaging [PDF]

, 2013
Inflammaging is characterized by the upregulation of the inflammatory response that occurs with advancing age; its roots are strongly embedded in evolutionary theory.Inflammaging is believed to be a consequence of a remodelling of the innate and acquired
Patel, Harnish P, BARTLETT, DAVID, Roberts, Helen C, Baylis, Daniel   +3 more
core   +2 more sources

Inflammaging in the intervertebral disc [PDF]

Clinical and Translational Neuroscience, 2018
Degeneration of the intervertebral disc – triggered by ageing, mechanical stress, traumatic injury, infection, inflammation and other factors – has a significant role in the development of low back pain. Back pain not only has a high prevalence, but also a major socio-economic impact. With the ageing population, its occurrence and costs are expected to
Aleksandra Sadowska, Oliver Nic Hausmann, Karin Wuertz-Kozak   +2 more
openaire   +3 more sources