Results 11 to 20 of about 18,204 (247)

Inflammaging as a prodrome to Alzheimer's disease [PDF]

Journal of Neuroinflammation, 2008
Recently, the term "inflammaging" was coined by Franceshci and colleagues to characterize a widely accepted paradigm that ageing is accompanied by a low-grade chronic up-regulation of certain pro-inflammatory responses. Inflammaging differs significantly
Rrapo Elona, Obregon Demian, Nikolic William V, Fernandez Francisco, Giunta Brian, Town Terrence, Tan Jun   +6 more
doaj   +4 more sources

Inflamma-miRs in aging and breast cancer: Are they reliable players? [PDF]

Frontiers in Medicine, 2015
Human aging is characterized by chronic low-grade inflammation known as inflammaging. Persistent low-level inflammation also plays a key role in all stages of breast cancer since inflammaging is the potential link between cancer and aging through NF-kB ...
Cristina Sorina Cătană, George eCalin, Ioana Berindan Neagoe, Ioana Berindan Neagoe, Ioana Berindan Neagoe   +4 more
doaj   +2 more sources

Pathogenesis and inflammaging in myelodysplastic syndrome

Haematologica
Myelodysplastic syndromes (MDS) are a genetically complex and phenotypically diverse set of clonal hematologic neoplasms that occur with increasing frequency with age.
Matthew T. Villaume, Michael R. Savona
doaj   +3 more sources

The stress polarity signaling (SPS) pathway serves as a marker and a target in the leaky gut barrier: implications in aging and cancer. [PDF]

, 2020
The gut barrier separates trillions of microbes from the largest immune system in the body; when compromised, a "leaky" gut barrier fuels systemic inflammation, which hastens the progression of chronic diseases.
Das, Soumita, Foretz, Marc, Ghosh, Pradipta, Ibeawuchi, Stella-Rita, Lim, Blaze B, Mittal, Yash, Sahoo, Debashis, Sayed, Ibrahim M, Swanson, Lee, Viollet, Benoit   +9 more
core   +3 more sources

Inflammaging: Implications in Sarcopenia

International Journal of Molecular Sciences, 2022
In a world in which life expectancy is increasing, understanding and promoting healthy aging becomes a contemporary demand. In the elderly, a sterile, chronic and low-grade systemic inflammation known as “inflammaging” is linked with many age-associated diseases. Considering sarcopenia as a loss of strength and mass of skeletal muscle related to aging,
Eduardo Antuña, Cristina Cachán-Vega, Juan Carlos Bermejo-Millo, Yaiza Potes, Beatriz Caballero, Ignacio Vega-Naredo, Ana Coto-Montes, Claudia Garcia-Gonzalez   +7 more
openaire   +4 more sources

How inflammaging diminishes adaptive immunity [PDF]

Nature Aging, 2021
Chambers et al. show that senescent skin cells in older adults provoke monocyte-dependent local inflammation in response to injury, which hampers T cell recall responses to viruses. Importantly, they further show that this phenomenon can be blocked pharmacologically to boost adaptive immunity.
Herbert, Kasler, Eric, Verdin
openaire   +2 more sources

Connecting aging biology and inflammation in the omics era

The Journal of Clinical Investigation, 2022
Aging is characterized by the accumulation of damage to macromolecules and cell architecture that triggers a proinflammatory state in blood and solid tissues, termed inflammaging.
Keenan A. Walker, Nathan Basisty, David M. Wilson III, Luigi Ferrucci   +3 more
doaj   +1 more source

Nutrition, diet and immunosenescence [PDF]

, 2013
Ageing is characterized by immunosenescence and the progressive decline in immunity in association with an increased frequency of infections and chronic disease.
Agrawal, Agrawal, Akbar, Almanzar, Alonso, Alperovich, Alvarez-Rodriguez, Arunachalam, Azzini, Bates, Bechoua, Belisle, Belisle, Berzins, Blomberg, Bogden, Borrego, Bouwens, Bravo, Buffa, Bunout, Butcher, Calder, Camous, Canaday, Cannizzo, Carluccio, Castle, Cevenini, Chandra, Chatta, Chidrawar, Chung, Ciaramella, Clambey, Clark, Claudio Nicoletti, Colonna-Romano, Corridan, Corsini, Cortes, Cossack, Currier, De La Fuente, De la Fuente, De la Fuente, De Martinis, DelaRosa, DelaRosa, Della Bella, Dell’Agli, Dewan, Di Lorenzo, Dong, Donnini, Dorshkind, Dubey, Duchateau, Dunn-Walters, Effros, Enos, Estruch, Farges, Fateh, Faunce, Fearnley, Feart, Fietta, Flores, Fortes, Fortin, Fortin, Franceschi, Franceschi, Frasca, Frasca, Fulop, Fulop, Fulop, Fulop, Galli, Gao, Gayoso, Gebremichael, Gibson, Gibson, Gill, Gill, Ginaldi, Gomez, Goronzy, Goronzy, Guigoz, Guigoz, Hadziabdic, Hakim, Hamilton-Miller, Haynes, Haynes, Haynes, Herndler-Brandstetter, Herrero, Herrero, Hilmer, Hodkinson, Hong, Ishimoto, Jing, Kahmann, Kamal Ivory, Khan, Kowdley, Larbi, Larbi, Lasheras, Le Garff-Tavernier, Lee, Lesourd, Lesourd, Ligthart, Lung, Magrone, Mariani, Mariani, Martinez-Gonzalez, Maue, McElhaney, Merchant, Meydani, Meydani, Meydani, Meydani, Mitchell, Monagas, Murasko, Mysliwska, Mònica Maijó, Nagel, Nicoletti, Nicoletti, Nikolich-Zugich, Nova, Nova, Ogawa, Ogawa, Osler, Ouwehand, Ouwehand, Pae, Paganelli, Pallast, Pawelec, Peralbo, Peralbo, Pfister, Plackett, Plowden, Prakash, Prasad, Prasad, Prasad, Prasad, Psaltopoulou, Pérez-Cabezas, Rees, Rink, Salas-Salvado, Sarah J. Clements, Saule, Saurwein-Teissl, Scarmeas, Scarmeas, Schenkein, Schiffrin, Schiffrin, Schwaiger, Shaw, Shodell, Simon R. Carding, Sofi, Sofi, Solana, Solana, Solana, Sridharan, Steger, Stout-Delgado, Swift, Tangney, Tasat, Tortorella, Tortorella, Trichopoulou, Uyemura, Valls-Pedret, van Duin, Varas, Vasto, Vasto, Vetvicka, Vulevic, Waitzberg, Wallace, Watson, Webster, Weiskopf, Weksler, Wenisch, Wikby, Willett, Wong, Wordsworth, Wu, Yaqoob, Yaqoob, Yuan, Zanni, Zissel   +217 more
core   +1 more source

Systems medicine of inflammaging [PDF]

Briefings in Bioinformatics, 2015
Systems Medicine (SM) can be defined as an extension of Systems Biology (SB) to Clinical-Epidemiological disciplines through a shifting paradigm, starting from a cellular, toward a patient centered framework. According to this vision, the three pillars of SM are Biomedical hypotheses, experimental data, mainly achieved by Omics technologies and ...
CASTELLANI, GASTONE, MENICHETTI, GIULIA, GARAGNANI, PAOLO, BACALINI, MARIA GIULIA, PIRAZZINI, CHIARA, FRANCESCHI, CLAUDIO, Collino, Sebastiano, SALA, CLAUDIA, REMONDINI, DANIEL, GIAMPIERI, ENRICO, Mosca, Ettore, BERSANELLI, MATTEO, VITALI, SILVIA, Do Valle, Italo Faria, Liò, Pietro, Milanesi, Luciano   +15 more
openaire   +5 more sources

Alzheimer’s Disease and Inflammaging

Brain Sciences, 2022
Alzheimer’s disease is one of the most common age-related neurodegenerative disorders. The main theory of Alzheimer’s disease progress is the amyloid-β cascade hypothesis. However, the initial mechanisms of insoluble forms of amyloid-β formation and hyperphosphorylated tau protein in neurons remain unclear.
Anna Kosyreva, Alexandra Sentyabreva, Ivan Tsvetkov, Olga Makarova   +3 more
openaire   +3 more sources