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Understanding how we age: insights into inflammaging [PDF]
, 2013 Inflammaging is characterized by the upregulation of the inflammatory response that occurs with advancing age; its roots are strongly embedded in evolutionary theory.Inflammaging is believed to be a consequence of a remodelling of the innate and acquired
Patel, Harnish P +3 more
core +2 more sources
Contribution of the inflammasome to inflammaging [PDF]
Journal of Inflammation, 2018 Inflammation is a natural part of the aging process. This process is referred to as inflammaging. Inflammaging has been associated with deleterious outcomes in the aging brain in diseases such as Alzheimer's disease and Parkinson's disease. The inflammasome is a multi-protein complex of the innate immune response involved in the activation of caspase-1
Nancy H. Mejias +3 more
openaire +3 more sources
Alzheimer’s Disease and Inflammaging
Brain Sciences, 2022 Alzheimer’s disease is one of the most common age-related neurodegenerative disorders. The main theory of Alzheimer’s disease progress is the amyloid-β cascade hypothesis. However, the initial mechanisms of insoluble forms of amyloid-β formation and hyperphosphorylated tau protein in neurons remain unclear.
Anna Kosyreva +3 more
openaire +3 more sources
Systems medicine of inflammaging [PDF]
Briefings in Bioinformatics, 2015 Systems Medicine (SM) can be defined as an extension of Systems Biology (SB) to Clinical-Epidemiological disciplines through a shifting paradigm, starting from a cellular, toward a patient centered framework. According to this vision, the three pillars of SM are Biomedical hypotheses, experimental data, mainly achieved by Omics technologies and ...
Gastone C. Castellani +15 more
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Inflammaging: Implications in Sarcopenia
International Journal of Molecular Sciences, 2022 In a world in which life expectancy is increasing, understanding and promoting healthy aging becomes a contemporary demand. In the elderly, a sterile, chronic and low-grade systemic inflammation known as “inflammaging” is linked with many age-associated diseases. Considering sarcopenia as a loss of strength and mass of skeletal muscle related to aging,
Eduardo Antuña +7 more
openaire +4 more sources
Inflammaging in the intervertebral disc [PDF]
Clinical and Translational Neuroscience, 2018 Degeneration of the intervertebral disc – triggered by ageing, mechanical stress, traumatic injury, infection, inflammation and other factors – has a significant role in the development of low back pain. Back pain not only has a high prevalence, but also a major socio-economic impact. With the ageing population, its occurrence and costs are expected to
Aleksandra Sadowska +2 more
openaire +3 more sources
Immunosenescence and inflammaging: Mechanisms and modulation through diet and lifestyle. [PDF]
Front ImmunolAging is associated with profound alterations in the immune system, characterized by immunosenescence and inflammaging, which together compromise host defense, promote chronic low-grade inflammation, and contribute to the development of age-related ...
Müller L, Di Benedetto S.
europepmc +2 more sources
Inflammaging in Dermatology: A New Frontier for Research
, 2021 As humans age, our ability to manage certain types of inflammation is reduced. As a result, we experience chronic, low-grade inflammation, which has been termed "inflammaging".
Woolery-Lloyd, Heather, Haque, Abid
core +1 more source
Neuro-Inflammaging and Psychopathological Distress
Biomedicines, 2022 Inflammaging is a low degree of chronic and systemic tissue inflammation associated with aging, and is intimately linked to pro-inflammatory mediators. These substances are involved in the pathogenesis of chronic inflammatory diseases and related psychopathological symptoms.
Giuseppe Murdaca +5 more
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Immunity & Ageing, 2023 Background Chronic, low-grade inflammation, also termed ‘inflammaging’, has been linked to the development of some aging-associated disorders. Recent studies suggest that inflammaging is attributable to aging-associated epidermal dysfunction.
Bin Yang +7 more
doaj +1 more source