Results 61 to 70 of about 18,204 (247)

Quantitative proteomic analysis of age-related subventricular zone proteins associated with neurodegenerative disease. [PDF]

, 2016
Aging is characterized by a progressive decline in the function of adult tissues which can lead to neurodegenerative disorders. However, little is known about the correlation between protein changes in the subventricular zone (SVZ) and neurodegenerative ...
AV Molofsky, AY Maslov, B Winner, C Franceschi, C Lopez-Otin, C Stapnes, C Zhang, CM Dong, D Vilchez, DG Healy, ET Powers, F Doetsch, GL Ming, GP Dimri, H Inadera, H Koga, I Ziabreva, J Campisi, JJ Rodriguez, JJ Rodriguez, JM Savitt, KJ Davies, L Liu, LK Felzien, M De la Fuente, N Awasthi, N Chondrogianni, N Chondrogianni, N Chondrogianni, RA Signer, RM Seaberg, S Katyal, S Ohta, SA van den Berge, SZ Young, V Della-Maggiore, WR Markesbery   +36 more
core   +1 more source

Clinical Characteristics of Geriatric Asthma in Guangxi of China: A Retrospective Comparative Descriptive Study

AGING MEDICINE, EarlyView.
Geriatric asthmatics exhibit more comorbidities, poorer lung function, higher neutrophil ratios, and elevated CRP levels. ABSTRACT Objective The research analyzed the clinical characteristics of geriatric and nongeriatric asthma cases, aiming to provide new insights into the diagnosis and management of geriatric asthma for clinicians.
Mengxia Gu, Qixiang Sun, Yujia Huang, Yuetian Deng, Xiaohong Jiang   +4 more
wiley   +1 more source

Identification of crucial inflammaging related risk factors in multiple sclerosis

Frontiers in Molecular Neuroscience
BackgroundMultiple sclerosis (MS) is an immune-mediated disease characterized by inflammatory demyelinating lesions in the central nervous system. Studies have shown that the inflammation is vital to both the onset and progression of MS, where aging ...
Mengchu Xu, Huize Wang, Siwei Ren, Bing Wang, Wenyan Yang, Ling Lv, Xianzheng Sha, Wenya Li, Yin Wang, Yin Wang   +9 more
doaj   +1 more source

Dietary phytochemicals and neuro-inflammaging: From mechanistic insights to translational challenges [PDF]

, 2016
An extensive literature describes the positive impact of dietary phytochemicals on overall health and longevity. Dietary phytochemicals include a large group of non-nutrients compounds from a wide range of plant-derived foods and chemical classes.
CORBI, GRAZIAMARIA, Davinelli, Sergio, Maes, Michael, Scapagnini, Giovanni, Willcox, Donald Craig, ZARRELLI, ARMANDO   +5 more
core   +1 more source

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

Physical exercise as a preventive procedures inflammation of aging [PDF]

, 2011
Ao longo do processo de envelhecimento observa-se complexa remodelagem do sistema imunitário. Estas alterações estão associadas ao desenvolvimento de patologias responsáveis por grande parte da mortalidade em população idosa.
Barros, Jonatas de França, Brito, Ciro José, Córdova, Claudio Olavo de Almeida, Mendes, Edmar Lacerda, Nóbrega, Otávio de Tolêdo, Roas, Aendria Fernanda Castro Martins, Silva Júnior, Fernando Lopes e, Volp, Ana Carolina Pinheiro   +7 more
core   +1 more source

Dietary fibre may mitigate sarcopenia risk:Findings from the NU-AGE cohort of older european adults [PDF]

, 2020
Sarcopenia is characterised by a progressive loss of skeletal muscle mass and physical function as well as related metabolic disturbances. While fibre-rich diets can influence metabolic health outcomes, the impact on skeletal muscle mass and function is ...
Battista, Giuseppe, Bazzocchi, Alberto, Berendsen, Agnes, de Groot, Lisette C.P.G.M., Fairweather-Tait, Susan, Feskens, Edith J.M., Franceschi, Claudio, Januszko, Olga, Jennings, Amy, Kadi, Fawzi, Montiel-Rojas, Diego, Nicoletti, Claudio, Nilsson, Andreas, Pietruszka, Barbara, Santoro, Aurelia   +14 more
core   +5 more sources

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Targeting Efferocytosis in Inflammaging

Annual Review of Pharmacology and Toxicology
Rapid removal of apoptotic cells by phagocytes, a process known as efferocytosis, is key for the maintenance of tissue homeostasis, the resolution of inflammation, and tissue repair. However, impaired efferocytosis can result in the accumulation of apoptotic cells, subsequently triggering sterile inflammation through the release of endogenous factors ...
Poon, Ivan K H, Ravichandran, Kodi S
openaire   +3 more sources