Results 61 to 70 of about 15,244 (279)

Immunosenescence and inflammaging in the aged horse

Immunity & Ageing, 2023
AbstractThe equine population in the United States and worldwide now includes a higher percentage of geriatric horses than ever previously recorded, and as methods to treat and manage elderly equids are developed and refined, this aging population will likely continue to expand. A better understanding of how horses age and the effect of age on immunity
Sally DeNotta, Dianne McFarlane
openaire   +3 more sources

Distribution and impact of p16INK4A+ senescent cells in elderly tissues: a focus on senescent immune cell and epithelial dysfunction

Experimental and Molecular Medicine
Cellular senescence, recognized as a key hallmark of aging, leads to the accumulation of senescent cells in various tissues over time. While the detrimental effects of these cells on age-related pathological conditions are well-documented, there is still
Soon Sang Park, Young-Kyoung Lee, Young Hwa Kim, So Hyun Park, Hee Young Kang, Jin Cheol Kim, Dong Jun Kim, Su Bin Lim, Gyesoon Yoon, Jang-Hee Kim, Yong Won Choi, Tae Jun Park   +11 more
doaj   +1 more source

Ficolin-2 inhibitors are present in sera after prolonged storage at −80 °C [PDF]

PeerJ, 2016
Ficolins can activate the lectin pathway of the complement system that provides innate immune protection against pathogens, marks host cellular debris for clearance, and promotes inflammation.
Kimball Aaron Geno, Richard E. Kennedy, Patricia Sawyer, Cynthia J. Brown, Moon H. Nahm   +4 more
doaj   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

The IRE1α Pathway Links Endoplasmic Reticulum Stress to Atherosclerosis-Related Inflammation and Lipid Accumulation

Mediators of Inflammation
Endoplasmic reticulum stress (ER stress) is closely related to the pathogenesis of atherosclerosis through various mechanisms, including inflammatory responses and foam cell formation.
Mariam Bagheri Ekta, Natalia Elizova, Stanislav Antonov, Alexander Orekhov, Vasily Sukhorukov   +4 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Regulation of inflammAging

Bioinformation
The non-neuronal cholinergic system plays an important role in the modulation of immunity and in particular the control of the inflammatory response. The cholinergic anti-inflammatory pathway is mediated principally by the α7-nicotinic acetylcholine receptor (α7-nAChR) and its receptor-specific chaperone, resistance to inhibitors of cholinesterase (RIC)
Chiappelli, Francesco, Fotovat, Lily, Khakshooy, Allen, Oluwadara, Oluwadayo, Penhaskashi, Jaden   +4 more
openaire   +2 more sources

Inflammaging at the Time of COVID-19

Clinics in Geriatric Medicine, 2022
Severe coronavirus disease 2019 (COVID-19) is associated with overproduction of proinflammatory cytokines. The ensuing cytokine storm contributes to the development of severe pneumonia and, possibly, to long-term symptom persistence (long COVID). The chronic state of low-grade inflammation that accompanies aging (inflammaging) might predispose older ...
Zazzara M. B., Bellieni A., Calvani R., Coelho-Junior H. J., Picca A., Marzetti E.   +5 more
openaire   +2 more sources

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

The LAV-BPIFB4-Platelet-CD47 Axis: A Novel Mechanism Associated With Immune Resilience in Longevity. [PDF]

Aging Cell
Centenarians display elevated CD47+ reticulated platelets, a trait recapitulated in LAV‐BPIFB4 carriers on total platelet pool. LAV‐BPIFB4 drives an early acquirement of CD47 surface expression, enabling platelets to suppress monocyte IL‐6 release. rhLAV‐BPIFB4 phenocopies the effects in non‐genetic carriers, establishing the platelet–CD47–monocyte ...
Ciaglia E, Esposito RM, Lopardo V, Montella F, Basile C, Longo R, Maciag A, Rescigno G, Damato A, Del Plato F, Finizio A, Vecchione C, Carrizzo A, Puca AA.   +13 more
europepmc   +2 more sources