Results 61 to 70 of about 14,164 (239)

From Senescent Cells to Systemic Inflammation: The Role of Inflammaging in Age-Related Diseases and Kidney Dysfunction

Cells
Aging is characterized by a chronic, low-grade inflammatory state known as inflammaging, which closely interacts with immunosenescence—the gradual deterioration of immune function.
Federica De Luca, Valentina Camporeale, Giorgia Leccese, Roberto Cuttano, Dario Troise, Barbara Infante, Giovanni Stallone, Giuseppe Stefano Netti, Elena Ranieri   +8 more
doaj   +1 more source

Inflammaging and Brain: Curcumin and Its Beneficial Potential as Regulator of Microglia Activation

Molecules, 2022
Inflammaging is a term used to describe the tight relationship between low-grade chronic inflammation and aging that occurs during physiological aging in the absence of evident infection.
Antonia Cianciulli, Rosa Calvello, Melania Ruggiero, Maria Antonietta Panaro   +3 more
doaj   +1 more source

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

Targeting the Notch Signaling Pathway to Treat Atherosclerosis

Cells
Atherosclerosis remains the principal underlying cause of myocardial infarction, ischemic stroke and peripheral artery disease, and its progression reflects a complex interplay between lipid accumulation, endothelial dysfunction, chronic vascular ...
Alexander Blagov, Daria Borodko, Ulyana Rozhkova, Stanislav Antonov, Aleksandra Utkina, Tatiana Kovyanova   +5 more
doaj   +1 more source

Shared and Distinguishing Features of Late‐Onset Rheumatic Diseases Fulfilling Polymyalgia Rheumatica Classification Criteria

Arthritis &Rheumatology, Accepted Article.
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Kerem Abacar, Ala Altaie, Andrew Barr, Sarah L. Mackie, Kulveer Mankia, Dennis McGonagle   +5 more
wiley   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Coated and Immobilized Polysaccharides‐Based Stationary Phases for Planar Metallocenes Enantioseparation in Liquid Chromatography

ELECTROPHORESIS, EarlyView.
This study examined 21 new ferrocene and ruthenocene derivatives, including those with planar and central chirality. Their stereochemical behavior was examined using UV‐detected normal‐phase liquid chromatography. Under fixed conditions, eight polysaccharide‐based chiral stationary phases were tested using n‐heptane combined with either 2‐propanol or ...
Florine Wartelle, Rose Leblond, Lisa Bonin, Alina Ghinet, Emmanuelle Lipka   +4 more
wiley   +1 more source

Inflammaging: triggers, molecular mechanisms, immunological consequences, sex differences, and cutaneous manifestations

Frontiers in Immunology
Inflammaging, defined as chronic, low-grade, systemic inflammation that increases with age in the absence of overt infection, is a phenomenon that was first described in 2000 as a member of a growing number of age-related processes that had pleiotropic ...
Ebru Karpuzoglu, Steven D. Holladay, Robert M. Gogal   +2 more
doaj   +1 more source

Cheek tooth extraction in geriatric versus non‐geriatric horses

Equine Veterinary Journal, EarlyView.
Abstract Background Age‐related dental changes are major contributors to dental disorders in older horses, and cheek tooth extractions are often required to maintain masticatory function and oral comfort. However, limited information is available on clinical and treatment characteristics in this older patient population.
Elias Mair, Omid Nekouei, Patricia Trummer‐Schug, Rhea Haralambus, Nora Mareike Biermann   +4 more
wiley   +1 more source