Results 51 to 60 of about 15,244 (279)
Cells, 2022 A senescence-associated secretory phenotype (SASP) and a mild inflammatory response characteristic of senescent cells (inflammaging) form the conditions for the development of cardiovascular diseases: atherosclerosis, coronary heart disease, and ...
Vladimir Khavinson +4 more
doaj +1 more source
Bone regeneration in inflammation with aging and cell-based immunomodulatory therapy
Inflammation and Regeneration, 2023 Aging of the global population increases the incidence of osteoporosis and associated fragility fractures, significantly impacting patient quality of life and healthcare costs. The acute inflammatory reaction is essential to initiate healing after injury.
Junichi Kushioka +8 more
doaj +1 more source
Cellular Mechanisms of Inflammaging and Periodontal Disease
Frontiers in Dental Medicine, 2022 Increased age is associated with an increased prevalence of chronic inflammatory diseases and conditions. The term inflammaging has been used to describe the age-related changes to the immune response that results in a chronic and elevated inflammatory ...
Daniel Clark +2 more
doaj +1 more source
Sex/gender-related differences in inflammaging [PDF]
, 2023 Geroscience puts mechanisms of aging as a driver of the most common age-related diseases and dysfunctions. Under this perspective, addressing the basic mechanisms of aging will produce a better understanding than addressing each disease pathophysiology ...
Olivieri, Fabiola +15 more
core +1 more source
Next steps in mechanisms of inflammaging [PDF]
Autophagy, 2020 Striking age-related changes occur in the human immune system, beginning in the sixth decade of life. Age is a non-modifiable, universal risk factor that results in the dysregulation of many cellular homeostatic processes. The decline in immune cell macroautophagy/autophagy and the increased generation of proinflammatory cytokines during agingfuels the
Leena P, Bharath, Barbara S, Nikolajczyk
openaire +2 more sources
Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging
Immunity & Ageing, 2020 Immune system aging is characterized by the paradox of immunosenescence (insufficiency) and inflammaging (over-reaction), which incorporate two sides of the same coin, resulting in immune disorder.
Rachel Thomas, Weikan Wang, Dong-Ming Su
doaj +1 more source
Periodontology 2000, EarlyView., 2023 Abstract In this descriptive analysis of the 21‐year follow‐up data from the SHIP‐START cohort and the 7‐year follow‐up data from the SHIP‐TREND cohort, we report the progression of clinical attachment levels (CAL), age effects on CAL change, and a detailed description of CAL progression and remission. At baseline, 4307 and 4420 persons participated in
Thomas Kocher +4 more
wiley +1 more source
“Inflammaging” and bone in the OsteoLaus cohort [PDF]
Immunity & Ageing, 2020 Abstract Background “Inflammaging” is a coined term that combines the processes of inflammation (within the normal range) and aging, since chronic, low-grade, systemic inflammation emerges with increasing age. Unlike high-level inflammation, with which deleterious effects on bone no longer need to be demonstrated, it is ...
Jessica Fischer +5 more
openaire +5 more sources
Neurovascular Inflammaging in Health and Disease [PDF]
Cells, 2020 Aging is characterized by a chronic low-grade sterile inflammation dubbed as inflammaging, which in part originates from accumulating cellular debris. These, acting as danger signals with many intrinsic factors such as cytokines, are sensed by a network of pattern recognition receptors and other cognate receptors, leading to the activation of ...
Ádám Mészáros +6 more
openaire +5 more sources
Epigenetic Mechanisms Involved in Inflammaging-Associated Hypertension
, 2022 Purpose of Review: This review summarizes the involvement of inflammaging in vascular damage with focus on the epigenetic mechanisms by which inflammaging-induced hypertension is triggered.
Ferder, León +3 more
core +2 more sources