Results 51 to 60 of about 18,204 (247)

The IRE1α Pathway Links Endoplasmic Reticulum Stress to Atherosclerosis-Related Inflammation and Lipid Accumulation

Mediators of Inflammation
Endoplasmic reticulum stress (ER stress) is closely related to the pathogenesis of atherosclerosis through various mechanisms, including inflammatory responses and foam cell formation.
Mariam Bagheri Ekta, Natalia Elizova, Stanislav Antonov, Alexander Orekhov, Vasily Sukhorukov   +4 more
doaj   +1 more source

Could Inflammaging and Its Sequelae Be Prevented or Mitigated? [PDF]

, 2019
Aged humans display a chronic and low-grade inflammation, termed "inflammaging", which has been potentially linked to the subsequent development of some aging-associated systemic disorders, including type 2 diabetes, atherosclerotic cardiovascular ...
Elias, Peter M, Man, Mao-Qiang
core  

Rusty microglia: trainers of innate immunity in Alzheimer's disease [PDF]

, 2018
Alzheimer's disease, the most common form of dementia, is marked by progressive cognitive and functional impairment believed to reflect synaptic and neuronal loss.
Adonis Sfera, Adonis Sfera, Amy I. Price, Carolina Osorio, Eddie Diaz, Michael Cummings, Roberto Gradini   +6 more
core   +2 more sources

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

A narrative review on inflammaging and late-onset hypogonadism

Frontiers in Endocrinology
The increasing life expectancy observed in recent years has resulted in a higher prevalence of late-onset hypogonadism (LOH) in older men. LOH is characterized by the decline in testosterone levels and can have significant impacts on physical and mental ...
Dong Xing, Yihan Jin, Baofang Jin
doaj   +1 more source

Gender-specific association of body composition with inflammatory and adipose-related markers in healthy elderly Europeans from the NU-AGE study [PDF]

, 2019
Objectives: The aim of this work was to examine the cross-sectional relationship between body composition (BC) markers for adipose and lean tissue and bone mass, and a wide range of specific inflammatory and adipose-related markers in healthy elderly ...
A Andreoli, A Bazzocchi, A Bazzocchi, A Bazzocchi, A Berendsen, A Santoro, Agnes Berendsen, Alberto Bazzocchi, Alessandro Napoli, AM Pino, Amy Jennings, Anna Brzozowska, Aurelia Santoro, B Can, B Chandrasekar, BM Spiegelman, C Franceschi, C Franceschi, C Franceschi, C Franceschi, Claudia Bertarelli, Claudio Franceschi, Claudio Nicoletti, Cristina Fabbri, CS Fox, D Diano, Daniele Mercatelli, E Wolsk, Edith Feskens, Elodie Caumon, Enrico Giampieri, F Prattichizzo, Fawzi Kadi, G Guglielmi, G Matarese, G Murdolo, Giulia Guidarelli, Giuseppe Battista, GS Hotamisligil, H Freisling, J Kullberg, JC Wells, JM Fernández-Real, Katarzyna Kozlowska, KM Kim, Lisette C. P. G. M. de Groot, LP Fried, M Cesari, M Zamboni, MA Schrager, Miriam Capri, MW Hamrick, MW Hamrick, MW Hamrick, N Yamaguchi, Nathalie Meunier, Olga Januszko, P JafariNasabian, P Mancuso, PA Kern, PS Suchdev, R Clarke, RE Hubbard, Rita Ostan, RJ Toombs, S Bas, S Dalle, S Guerri, S Marttila, SM Bartell, Susan Fairweather-Tait, T Lemos, T Pischon, T Thomas, TE Brinkley, V Morrisette-Thomas   +75 more
core   +3 more sources

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Cardiovascular Inflammaging: Mechanisms and Translational Aspects

Cells, 2022
Aging is one of the major non-reversible risk factors for several chronic diseases, including cancer, type 2 diabetes, dementia, and cardiovascular diseases (CVD), and it is a key cause of multimorbidity, disability, and frailty (decreased physical activity, fatigue, and weight loss).
Maria Luisa Barcena, Muhammad Aslam, Sofya Pozdniakova, Kristina Norman, Yury Ladilov   +4 more
openaire   +4 more sources

Menopause and adipose tissue : miR-19a-3p is sensitive to hormonal replacement [PDF]

, 2017
Tissue-specific effects of 17 beta-estradiol are delivered via both estrogen receptors and microRNAs (miRs). Menopause is known to affect the whole-body fat distribution in women.
Aukee, Pauliina, Capri, Miriam, Franceschi, Claudio, Kangas, Reeta, Kaprio, Jaakko, Kovanen, Vuokko, Laakkonen, Eija K., Lanzarini, Catia, Morsiani, Cristina, Pizza, Grazia, Sipilä, Sarianna   +10 more
core   +1 more source

Senomorphic Small Extracellular Vesicles Delivered by a Tissue‐Adhesive α‐Lipoic‐Acid Hydrogel Enable Immuno‐Rejuvenation for Bone‐Tendon Interface Regeneration

Advanced Science, EarlyView.
This work identifies M1 macrophage‐mediated inflammation as a key driver of BMSC senescence and bone microstructural deterioration at the enthesis. A tissue‐adhesive hydrogel delivering senomorphic small extracellular vesicles suppresses this inflammatory‐senescent cascade and enhances BMSC resilience by inhibiting the cGAS‐STING‐NF‐κB pathway.
Lingzhi Kong, Wei Song, Wencai Liu, Hui Xu, Yuhao Yu, Xinyue Yang, Haiyan Li, Yanlun Zhu, Yaohua He   +8 more
wiley   +1 more source