Results 81 to 90 of about 18,204 (247)

Social support moderates D-dimer and self-rated successful aging within people with HIV and older adults. [PDF]

, 2020
Many factors can influence perceptions of successful aging (SA), including social isolation and poor physical health. We hypothesized that social support attenuates the negative effect of plasma D-dimer, a correlate of HIV and aging, on SA.
Jeste, Dilip V, Kohli, Maulika, Letendre, Scott, Moore, David J, Morgan, Erin, Pasipanodya, Elizabeth, Serrano, Vanessa, Sun-Suslow, Ni   +7 more
core   +1 more source

Mapping the subgingival HerBiome and HisBiome over the human healthspan

Journal of Periodontology, EarlyView.
Abstract Background Understanding the intricate relationship between sex, age, and the oral microbiome is crucial for deciphering the onset and progression of numerous age‐related oral and systemic diseases. Methods Subgingival plaque was collected from 781 periodontally and systemically healthy females and 160 males spanning 0 to 80 years.
Rahul Nikam, Kazune Pax, Michelle Lee‐Scott Beverly, Purnima S. Kumar   +3 more
wiley   +1 more source

Regulation of inflammAging

Bioinformation
The non-neuronal cholinergic system plays an important role in the modulation of immunity and in particular the control of the inflammatory response. The cholinergic anti-inflammatory pathway is mediated principally by the α7-nicotinic acetylcholine receptor (α7-nAChR) and its receptor-specific chaperone, resistance to inhibitors of cholinesterase (RIC)
Chiappelli, Francesco, Fotovat, Lily, Khakshooy, Allen, Oluwadara, Oluwadayo, Penhaskashi, Jaden   +4 more
openaire   +1 more source

Aging and periodontitis increase brain dissemination of oral bacteria

Journal of Periodontology, EarlyView.
Abstract Background The microbiome is a dynamic system that changes throughout life. Studies have revealed the relationship between periodontal disease and the oral microbiota; however, the impact of periodontal disease on the expression of senescence markers and on the inflammaging of the oral and systemic microbiome remains unclear.
Ozge Unlu, Tsute Chen, Nil Yakar, Zeliha Guney, Bruce Paster, Isabel Carreras, Alpaslan Dedeoglu, Alpdogan Kantarci   +7 more
wiley   +1 more source

One-Year Consumption of a Mediterranean-Like Dietary Pattern With Vitamin D3 Supplements Induced Small Scale but Extensive Changes of Immune Cell Phenotype, Co-receptor Expression and Innate Immune Responses in Healthy Elderly Subjects:Results From the United Kingdom Arm of the NU-AGE Trial [PDF]

, 2018
Amongst the major features of aging are chronic low grade inflammation and a decline in immune function. The Mediterranean diet (MedDiet) is considered to be a valuable tool to improve health status, and although beneficial effects have been reported, to
Bashir, Berendsen, Casas, Casas, Castle, Cevenini, Cevenini, Clements, De Martinis, Della Bella, Dewan, Esposito, Fragopoulou, Franceschi, Franceschi, Franceschi, Franceschi, Gayoso, Jani, Jing, Lee, Lencel, Li, Li, Maijó, Man, Martinez-Gonzalez, Mena, Monti, Pae, Pedersen, Peralbo, Peregrin, Prietl, Pérez-Cabezas, Quezada, Rea, Robinson, Santangelo, Santoro, Shelnutt, Shodell, Stout-Delgado, Tortorella, Varadhan, Vasto, Yamamoto   +46 more
core   +2 more sources

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Glutathione increase by the n-butanoyl glutathione derivative (GSH-C4) inhibits viral replication and induces a predominant Th1 immune profile in old mice infected with influenza virus [PDF]

, 2019
During aging, glutathione (GSH) content declines and the immune system undergoes a deficiency in the induction of Th1 response. Reduced secretion of Th1 cytokines, which is associated with GSH depletion, could weaken the host defenses against viral ...
Amatore, D, Brundu, S, Celestino, I, Checconi, P, Coluccio, P, Fraternale, A, Galluzzi, L, Magnani, M, Nencioni, L, Palamara, A. T.   +9 more
core   +1 more source

Determinants of Immunoglobulin‐G N‐Glycan Patterns in the Aging General Population

Allergy, EarlyView.
The effect of demographic and lifestyle factors on IgG N‐glycosylation, which determines IgG's inflammatory response, remains poorly characterized. Aging, higher BMI, female sex, smoking, and heavy alcohol consumption are determinants of IgG N‐glycome patterns, which are indicative of inflammation. Women exhibit a distinct change in IgG N‐glycosylation
Samantha Leonard, Ralph Heijmans, Virgil A. S. H. Dalm, Silvan Licher, Jan Nouta, Steinar Gijze, David Falck, P. Martin van Hagen, Robin Peeters, Manfred Wuhrer, Layal Chaker   +10 more
wiley   +1 more source

Differences in Proinflammatory Cytokines and Monocyte Subtypes in Older as Compared With Younger Kidney Transplant Recipients. [PDF]

, 2018
Background:The number of elderly patients with end-stage kidney disease requiring kidney transplantation continues to grow. Evaluation of healthy older adults has revealed proinflammatory changes in the immune system, which are posited to contribute to ...
Abdalla, Basmah, Bunnapradist, Suphamai, Danovitch, Gabriel, Groysberg, Victoria, Korin, Yael, Liang, Emily C, Lum, Erik, Pham, Phuong-Thu, Reed, Elaine F, Rossetti, Maura, Schaenman, Joanna, Sidwell, Tiffany, Sunga, Gema, Vangala, Sitaram   +13 more
core   +1 more source

Serum cytokine profiles in healthy young and elderly population assessed using multiplexed bead-based immunoassays [PDF]

, 2011
Background Lipid metabolites and cytokines, including chemokines and growth factors, are the key regulators of immune cell function and differentiation, and thus, dysregulation of these regulators is associated with various human diseases ...
Hyun Kim, Han-Soo Kim, Jong-Chan Youn, Eui-Cheol Shin, Sungha Park   +4 more
core   +2 more sources