Results 101 to 110 of about 18,204 (247)

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Groeger Sabine Elisabeth, Zhou Yuxi, Yong Jiawen, Wang Lei, Ruf Sabine, Meyle Joerg   +5 more
wiley   +1 more source

Mitochondrial (Dys) Function in Inflammaging: Do MitomiRs Influence the Energetic, Oxidative, and Inflammatory Status of Senescent Cells?

Mediators of Inflammation, 2017
A relevant feature of aging is chronic low-grade inflammation, termed inflammaging, a key process promoting the development of all major age-related diseases.
Angelica Giuliani, Francesco Prattichizzo, Luigina Micolucci, Antonio Ceriello, Antonio Domenico Procopio, Maria Rita Rippo   +5 more
doaj   +1 more source

Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice. [PDF]

, 2014
Aging is a contributing factor in cancer occurrence. We recently demonstrated that systemic immunotherapy (IT) administration in aged, but not young, mice resulted in induction of rapid and lethal cytokine storm.
Blazar, Bruce, Bouchlaka, Myriam, Chen, Mingyi, Ferrucci, Luigi, Fishbein, Kenneth, Hesdorffer, Charles, Longo, Dan, Martin, Bronwen, Maudsley, Stuart, Maverakis, Emanuel, Mirsoian, Annie, Monjazeb, Arta, Murphy, William, Pai, Chien-Chun, Sckisel, Gail, Siddiqui, Sana, Spencer, Richard, Taub, Dennis, Wiltrout, Robert   +18 more
core   +1 more source

Biomarkers of aging associated with past treatments in breast cancer survivors. [PDF]

, 2017
Radiation and chemotherapy are effective treatments for cancer, but are also toxic to healthy cells. Little is known about whether prior exposure to these treatments is related to markers of cellular aging years later in breast cancer survivors.
Bower, Julienne E, Breen, Elizabeth C, Carroll, Judith E, Chapman, Aaron M, Esquivel, Stephanie, Ganz, Patricia A, Hogan, Matt, Irwin, Michael R, Petersen, Laura, Ramos-Perlberg, Sam, Schiestl, Robert, Scuric, Zorica   +11 more
core   +2 more sources

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

Photothermal Microneedle Hydrogel Patch for Refractory Soft Tissue Injuries through Thermosensitized Anti‐Inflammaging Modulation

Small Structures
Soft tissue injuries (STIs) are the most common cause of extremity pain and motion dysfunction. Persistent inflammatory activation of immune cells characterized by senescence‐associated secretory phenotype (SASP) and mitochondrial stress are considered ...
Wanbo Zhu, Quan Liu, Ziheng Zhang, Yingjie Wang, Jiawei Mei, Dongdong Xu, Jun Zhou, Zheng Su, Xianzuo Zhang, Chen Zhu, Jiaxing Wang, Junchen Zhu, Xiaochun Peng, Xianlong Zhang   +13 more
doaj   +1 more source

Senescent cell-derived extracellular vesicles as potential mediators of innate immunosenescence and inflammaging

Experimental Gerontology
Ageing is accompanied by a decline in immune function (immunosenescence), increased inflammation (inflammaging), and more senescent cells which together contribute to age-related disease and infection susceptibility. The innate immune system is the front-
Shaun Hanley, Yung-Yi Chen, Jon Hazeldine, Janet M. Lord   +3 more
doaj   +1 more source

Inflammation, genetic background and longevity [PDF]

, 2010
Ageing is an inexorable intrinsic process that affects all cells, tissues, organs and individuals. Due to a diminished homeostasis and increased organism frailty, ageing causes a reduction of the response to environmental stimuli and, in general, is
A Panda, B Grubeck-Loebenstein, BR Troen, C Caruso, C Franceschi, C Franceschi, C Franceschi, C Franceschi, C Miyaji, C Wei, Calogero Caruso, CE Finch, CR Balistreri, D Di Bona, D Duin van, DP Harris, E Cevenini, F Licastro, F Listì, F Listì, F Martin, G Candore, G Candore, G Candore, G Candore, G Candore, G Colonna-Romano, G Colonna-Romano, G Colonna-Romano, G Di Lorenzo, G Pawelec, G Pawelec, G Pawelec, Giuseppina Candore, Giuseppina Colonna-Romano, HY Chung, I Sanz, J Oeppen, K Ogata, KF Kong, KL Gibson, KP High, M Capri, M Goto, M Jylhä, M la Fuente De, M Martinis De, MP Viveros, OT Chan, P Alonso-Fernández, P Sansoni, P Szabo, P Trzonkowski, R Ostan, R Vescovini, S Gupta, S Salvioli, S Vasto, S Vasto, S Vasto, S Vasto, SI Rattan, SJ Olshansky, Y Niwa, Y Shi, Y Shi   +65 more
core   +1 more source

IMMUNOMETABOLIC CHECKPOINTS OF INFLAMMAGING

Innovation in Aging, 2023
Abstract Inflammation is a key hallmark and driver of age-related functional decline. Evidence that innate immune sensor NLRP3 inflammasome links aging to functional decline supports Metchnikoff’s original prediction that phagocytes or macrophages drive aging-associated degenerative diseases in an organism.
openaire   +1 more source

Oral wound healing in the elderly: Mechanisms, challenges, and innovations

Periodontology 2000, EarlyView.
Abstract Objective This narrative synthesizes current knowledge on the biological mechanisms, clinical challenges, and regenerative innovations for optimizing intraoral wound healing in the elderly. Methods Narrative review of preclinical and clinical studies addressing age‐related changes in the four canonical wound‐healing phases (hemostasis ...
Ann M. Decker, Sandra H. Stuhr, Gustavo Avila‐Ortiz, Andrea Pilloni, Lorenzo Marini, Rogerio Castilho, Beth I. Wallace, Yvonne L. Hernandez‐Kapila   +7 more
wiley   +1 more source