Results 101 to 110 of about 15,244 (279)

Aging and periodontitis increase brain dissemination of oral bacteria

Journal of Periodontology, EarlyView.
Abstract Background The microbiome is a dynamic system that changes throughout life. Studies have revealed the relationship between periodontal disease and the oral microbiota; however, the impact of periodontal disease on the expression of senescence markers and on the inflammaging of the oral and systemic microbiome remains unclear.
Ozge Unlu, Tsute Chen, Nil Yakar, Zeliha Guney, Bruce Paster, Isabel Carreras, Alpaslan Dedeoglu, Alpdogan Kantarci   +7 more
wiley   +1 more source

Senescent cell-derived extracellular vesicles as potential mediators of innate immunosenescence and inflammaging

Experimental Gerontology
Ageing is accompanied by a decline in immune function (immunosenescence), increased inflammation (inflammaging), and more senescent cells which together contribute to age-related disease and infection susceptibility. The innate immune system is the front-
Shaun Hanley, Yung-Yi Chen, Jon Hazeldine, Janet M. Lord   +3 more
doaj   +1 more source

THE NLRC4 INFLAMMASOME CONTRIBUTES TO BRAIN INFLAMMAGING

, 2017
Inflammation is a natural part of aging in a process known as inflammaging. Inflammaging has been associated with deleterious outcomes in the aging brain. It is believed that inflammaging precedes the onset of neurodegenerative diseases such as Alzheimer’
N.H. Mejias, de Rivero Vaccari, J, J. de Rivero Vaccari, F. Travascio, Travascio, F, Mejias, N.H   +5 more
core   +1 more source

The inflammaging microenvironment induces dysfunctional rewiring of Tfh cell differentiation

JCI Insight
Humoral immunity is orchestrated by follicular helper T (Tfh) cells, which promote cognate B cells to produce high-affinity, protective antibodies. In aged individuals, humoral immunity after vaccination is diminished despite the presence of Tfh cells ...
Cody S. Nelson, M. A. Podestà, M. Gempler, Jeong-Mi Lee, Cole Batty, P. Mathenge, Asra Sainju, M. Chang, Hanzhong Ke, P. Chandrakar, E. Bechu, Sierra Richardson, Cecilia B. Cavazzoni, Stefan G. Tullius, R. Abdi, M. Ghebremichael, Marcia C. Haigis, Wayne A. Marasco, Peter T. Sage   +18 more
semanticscholar   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Alpha synuclein and inflammaging

Heliyon
The α-synuclein protein is an established molecule in Lewy body pathology, especially Parkinson's disease (PD). While the pathological role of α-synuclein (α-syn) in PD has been well described, novel evidence may suggest that α-syn interacts with inflammasomes in response to aging.
Geneviève L. Putnam, Robert W. Maitta
openaire   +3 more sources

LINE-1 derepression in senescent cells triggers interferon and inflammaging

Nature, 2019
Retrotransposable elements are deleterious at many levels, and the failure of host surveillance systems for these elements can thus have negative consequences. However, the contribution of retrotransposon activity to ageing and age-associated diseases is
M. Cecco, Takahiro Ito, Anna P. Petrashen, Amy E Elias, Nicholas Skvir, Steven W. Criscione, Alberto Caligiana, Alberto Caligiana, Greta Brocculi, Greta Brocculi, E. Adney, J. Boeke, Oanh Lê, C. Beauséjour, J. Ambati, Kameshwari Ambati, M. Simon, A. Seluanov, V. Gorbunova, P. Slagboom, S. Helfand, N. Neretti, J. Sedivy   +22 more
semanticscholar   +1 more source

Determinants of Immunoglobulin‐G N‐Glycan Patterns in the Aging General Population

Allergy, EarlyView.
The effect of demographic and lifestyle factors on IgG N‐glycosylation, which determines IgG's inflammatory response, remains poorly characterized. Aging, higher BMI, female sex, smoking, and heavy alcohol consumption are determinants of IgG N‐glycome patterns, which are indicative of inflammation. Women exhibit a distinct change in IgG N‐glycosylation
Samantha Leonard, Ralph Heijmans, Virgil A. S. H. Dalm, Silvan Licher, Jan Nouta, Steinar Gijze, David Falck, P. Martin van Hagen, Robin Peeters, Manfred Wuhrer, Layal Chaker   +10 more
wiley   +1 more source

Role of inflammaging in the development of chronic heart failure and osteoporosis: A literature review [PDF]

КардиоСоматика
The interaction between heart failure (HF) and osteoporosis in a multimorbid patient is a relevant complication in the aging population. The concept of inflammaging (inflammatory aging) allows us to consider the prolonged process of subclinical ...
Vera N. Larina, Ekaterina S. Shcherbina
doaj   +1 more source

Mitochondrial (Dys) Function in Inflammaging: Do MitomiRs Influence the Energetic, Oxidative, and Inflammatory Status of Senescent Cells?

Mediators of Inflammation, 2017
A relevant feature of aging is chronic low-grade inflammation, termed inflammaging, a key process promoting the development of all major age-related diseases.
Angelica Giuliani, Francesco Prattichizzo, Luigina Micolucci, Antonio Ceriello, Antonio Domenico Procopio, Maria Rita Rippo   +5 more
doaj   +1 more source