Results 121 to 130 of about 14,164 (239)

Anthraquinones and Aloe Vera Extracts as Potential Modulators of Inflammaging Mechanisms: A Translational Approach from Autoimmune to Onco-Hematological Diseases

Molecules
Inflammaging is a chronic, low-grade inflammatory state that contributes to age-related diseases, including cardiovascular disorders, osteoporosis, neurodegeneration, and cancer. This process involves immunosenescence, oxidative stress, and immune aging,
Raffaele Cordiano, Santino Caserta, Paola Lucia Minciullo, Alessandro Allegra, Sebastiano Gangemi   +4 more
doaj   +1 more source

Immune dysregulation in the prostates of C57BL/6Aire−/− mice mirrors that seen in human benign prostatic hyperplasia

The Journal of Pathology, Volume 270, Issue 2, Page 211-225, October 2026.
Abstract Benign prostatic hyperplasia (BPH) is the most common urologic disease in aging men, resulting in significant morbidity. The etiologies of BPH are unknown, though chronic prostatic inflammation is known to promote hyperplasia, fibrotic remodeling, and therapeutic resistance in BPH.
Nadia A Lanman, Meaghan M Broman, Harish Kothandaraman, Gregory M Cresswell, Gada D Awdalkreem, Dilinaer Wusiman, Andree K Kolliegbo, Alexander P Glaser, Brian T Helfand, Renee E Vickman, Jiang Yang, Simon W Hayward, Timothy L Ratliff   +12 more
wiley   +1 more source

Real‐World Effectiveness and Safety of Finerenone in People With Type 2 Diabetes and Chronic Kidney Disease: A Spanish Multicentre Retrospective Observational Study (MEDFINE‐RWD)

Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 9461-9472, October 2026.
ABSTRACT Aim Although finerenone has shown efficacy in randomized trials, evidence from routine clinical practice remains limited. We aimed to assess the real‐world effectiveness and safety of finerenone in people with type 2 diabetes (PWT2D) and chronic kidney disease (CKD), with a particular focus on residual cardiorenal risk as reflected by changes ...
Oscar Moreno‐Pérez, Antonio Tejera‐Muñoz, Patricia Tomás‐Gómez, Federico Vázquez‐San Miguel, Virginia Soria‐Utrilla, Ada María Roldán‐Sánchez, Maya Sánchez‐Baya, Jersy Cárdenas‐Salas, Blanca Timón‐Vázquez, Juan J. Gorgojo‐Martínez, Ines Modrego‐Pardo, Irea Fernández‐Xove, Jose Carlos Fernández‐García, Rebeca Reyes‐García   +13 more
wiley   +1 more source

Characterization of age-associated inflammasome activation reveals tissue specific differences in transcriptional and post-translational inflammatory responses

Immunity & Ageing
Aging is associated with systemic chronic, low-grade inflammation, termed ‘inflammaging’. This pattern of inflammation is multifactorial and is driven by numerous inflammatory pathways, including the inflammasome.
Sarah Talley, Tyler Nguyen, Lily Van Ye, Rasa Valiauga, Jake DeCarlo, Jabra Mustafa, Benjamin Cook, Fletcher A. White, Edward M. Campbell   +8 more
doaj   +1 more source

USP18 Serves as a Key Mediator of cGAS‐STING for Cardiac Aging in Diabetes

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Diabetes accelerates cardiac aging, but the molecular mechanisms that link metabolic stress to myocardial senescence remain insufficiently defined. This study investigated factors driving diabetes‐associated cardiac aging with a focus on the role of USP18.
Xunxi Deng, Zhiyi Yin, Shi Tai, Hejun Jiang, Yuying Zhou, Yongjun Wang, Liyao Fu   +6 more
wiley   +1 more source

Anemia in the frail, elderly patient

Clinical Interventions in Aging, 2016
Gabriele Röhrig1,2 1Ageing Clinical Research, Department II of Internal Medicine, University Hospital Cologne, 2Department of Geriatrics, St Marien Hospital Cologne, Cologne, Germany Abstract: Anemia and frailty are two common findings in ...
Röhrig G
doaj  

A Review of Senescence‐Associated Secretory Phenotype‐Mediated Remodeling of the Tumor Microenvironment: Implications for Cancer Progression and Therapy

Cancer Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background Cellular senescence influences cancer progression through irreversible cell‐cycle arrest, immune surveillance, and paracrine signaling mediated by the senescence‐associated secretory phenotype (SASP). SASP comprises inflammatory cytokines, chemokines, growth factors, and matrix‐remodeling enzymes that regulate the tumor ...
Sneha Pallatt, Sibin Nambidi, Antara Banerjee, Surajit Pathak   +3 more
wiley   +1 more source

Inflammaging and cardiovascular disease: Management by medicinal plants. [PDF]

, 2016
BACKGROUND In aging, a host of molecular and cellular changes occur which accelerate alteration and progression of inflammatory diseases. These conditions in the elderly people cause appearance of a phenomenon which has been denoted as "inflammaging".
Rafieian-Kopaei, Mahmoud., Shayganni, Erfaneh., Asgary, Sedigheh., Bahmani, Mahmoud.   +3 more
core   +2 more sources

Citrus fruits and inflammaging: a systematic review

, 2019
Inflammaging is a low-grade, chronic, asymptomatic, controlled and systemic pro-inflammatory status that appears during the aging process and is linked to many age-related diseases.
Minciullo, Paola Lucia, Navarra, Michele, Cirmi, Santa, Gangemi, Sebastiano, Calapai, Gioacchino, Maugeri, Alessandro, Mollace, Vincenzo   +6 more
core   +1 more source

Systemic Inflammation and Subclinical Hepatic Synthetic Dysfunction Following Doxorubicin‐Cyclophosphamide Chemotherapy in Ethiopian Women With Breast Cancer: A Prospective Cohort Study

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims Doxorubicin‐cyclophosphamide (AC) chemotherapy induces hepatotoxicity through oxidative stress and inflammatory pathway activation, but prospective African data are lacking and conventional liver tests may miss subclinical injury.
Tamrat Nida, Abdisa Tufa Bedada
wiley   +1 more source