Results 111 to 120 of about 15,244 (279)

Comments to the “Letter to the Editor” for the manuscript titled “Increased expression of inflammasome signaling genes and proteins in selective brain regions in the intermediate stage of Alzheimer's disease”

Brain Pathology, EarlyView.
Beta amyloid diffuse plaques, neurofibrillary tangles and neuritic plaques, are increased in densities at the intermediate stage of Alzheimer's neuropathological change. These pathological changes releasing Pathogen‐Associated Molecular Patterns (PAMPs) and Damage‐Associated Molecular Patterns (DAMPs).
Juan Pablo de Rivero Vaccari, David A. Davis, Andrew P. Sawaya, Susanna P. Garamszegi, Xiaoyan Sun, Ayled Barreda, Helen M. Bramlett, Sakir Humayun Gultekin, W. Dalton Dietrich, Robert W. Keane, Regina T. Vontell   +10 more
wiley   +1 more source

Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice

Frontiers in Immunology, 2017
Advanced age is associated with chronic low-grade inflammation, which is usually referred to as inflammaging. Elderly are also known to have an altered gut microbiota composition.
Floris Fransen, Floris Fransen, Adriaan A. van Beek, Adriaan A. van Beek, Theo Borghuis, Theo Borghuis, Sahar El Aidy, Floor Hugenholtz, Floor Hugenholtz, Christa van der Gaast – de Jongh, Huub F. J. Savelkoul, Marien I. De Jonge, Mark V. Boekschoten, Mark V. Boekschoten, Hauke Smidt, Hauke Smidt, Marijke M. Faas, Marijke M. Faas, Paul de Vos, Paul de Vos   +19 more
doaj   +1 more source

A comprehensive review of cancer‐induced cardiac wasting

British Journal of Pharmacology, EarlyView.
Cancer is frequently accompanied by cachexia, a systemic syndrome characterized by progressive loss of skeletal muscle mass, with or without loss of fat mass. Increasing evidence indicates that cancer can also induce cardiac muscle wasting, which is associated with structural cardiac remodelling, impaired contractile function and the development of ...
Alessia Lena, Muhammad Shahzeb Khan, Ulrich Keller, Lars Bullinger, Dominik P. Modest, Markus S. Anker   +5 more
wiley   +1 more source

Corylin ameliorates inflammaging and pyroptosis in diabetic periodontitis: A preliminary in vitro study

Journal of Dental Sciences
Background/purpose: Diabetic periodontitis (DP) is a severe oral disease characterized by hyperinflammation and impaired wound healing, with inflammaging and pyroptosis playing key roles in its pathogenesis.
Taichen Lin, Min Yee Ng, Chun-Te Ho, Yi-Wen Liao, Cheng-Chia Yu, Chun-Jung Chen   +5 more
doaj   +1 more source

Inflamma-miRs in aging and breast cancer: Are they reliable players?

Frontiers in Medicine, 2015
Human aging is characterized by chronic low-grade inflammation known as inflammaging. Persistent low-level inflammation also plays a key role in all stages of breast cancer since inflammaging is the potential link between cancer and aging through NF-kB ...
Cristina Sorina Cătană, George eCalin, Ioana Berindan Neagoe, Ioana Berindan Neagoe, Ioana Berindan Neagoe   +4 more
doaj   +1 more source

Changes in plasma metabolite concentrations and enzyme activities in aging riding horses

Frontiers in Veterinary Science
In older horses, basal metabolic rate decreases, and plasma metabolite and hormone concentrations related to energy metabolism change. The occurrence of age-related diseases, which increases in old animals, may enhance inflammatory reactivity ...
Yukari Asahi, Toshiro Arai, Yoshikazu Tanaka   +2 more
doaj   +1 more source

Understanding and addressing resistance to IMiDs immunomodulatory compounds in multiple myeloma

The FEBS Journal, EarlyView.
IMiDs are pivotal in the treatment of multiple myeloma. Mechanisms of resistance comprise cell intrinsic and extrinsic pathways, involving tumour microenvironment, immune cell dysfunction, CRBN‐dependent and independent genetic drivers and epigenetic changes.
Maria‐Cynthia Fuentes‐Lacouture, Devi Nandana, Karthik Ramasamy, Anjan Thakurta   +3 more
wiley   +1 more source

Mechanisms underlying the protective effects of San‐Bai decoction against UV radiation on the skin

International Journal of Cosmetic Science, EarlyView.
Combining conventional differential expression analysis with differential network analysis offers a promising strategy to uncover the mechanistic basis of the holistic benefits provided by herbal blends. Our findings demonstrated that San‐Bai decoction modulates multiple pathways—not only those related to skin pigmentation, such as ET‐1 signalling, but
Rui Zhang, Hong Zhang, Chengming Zhang, Wencai Jiang, Luonan Chen, Yimei Tan, Ying Zou, Xuelan Gu   +7 more
wiley   +1 more source

Inflammaging and cardiovascular disease: Management by medicinal plants [PDF]

, 2016
Background In aging, a host of molecular and cellular changes occur which accelerate alteration and progression of inflammatory diseases. These conditions in the elderly people cause appearance of a phenomenon which has been denoted as “inflammaging ...
Rafieian-Kopaei, Mahmoud., Shayganni, Erfaneh., Asgary, Sedigheh., Bahmani, Mahmoud.   +3 more
core  

Highlights of 2025: advances in germinal centers

Immunology &Cell Biology, EarlyView.
Graphical summary of research advances made in 2025 in germinal center (GC) biology. GCB, germinal center B cells; Tfh, T follicular helper cell; APC, antigen‐presenting cell; FDC, follicular dendritic cell; SHM, somatic hypermutation. Created in BioRender. Webb, L. (2026) https://BioRender.com/bn9jx9v.
Louise MC Webb, Michelle A Linterman
wiley   +1 more source