Results 111 to 120 of about 18,204 (247)
International Journal of Molecular SciencesProgress made by the medical community in increasing lifespans comes with the costs of increasing the incidence and prevalence of age-related diseases, neurodegenerative ones included. Aging is associated with a series of morphological changes at the tissue and cellular levels in the brain, as well as impairments in signaling pathways and gene ...
Maria Carolina Jurcau +5 more
openaire +2 more sources
The Aging Heart: Mitophagy at the Center of Rejuvenation. [PDF]
, 2020 Aging is associated with structural and functional changes in the heart and is a major risk factor in developing cardiovascular disease. Many recent studies have focused on increasing our understanding of the basis of aging at the cellular and molecular ...
Gustafsson, Åsa B, Liang, Wenjing J
core +1 more source
Bone biology in aging periodontal and peri‐implant tissues
Periodontology 2000, EarlyView.Abstract Background Periodontal disease is an age‐related chronic inflammatory condition leading to tooth loss. Dental implants are an option for replacement of lost teeth in older adults. However, age‐related changes to alveolar bone may have pathological implications for its role in supporting the dentition and dental implants.
Dalia Rasheed Issa +2 more
wiley +1 more source
Journal of Dental SciencesBackground/purpose: Diabetic periodontitis (DP) is a severe oral disease characterized by hyperinflammation and impaired wound healing, with inflammaging and pyroptosis playing key roles in its pathogenesis.
Taichen Lin +5 more
doaj +1 more source
Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice
Frontiers in Immunology, 2017 Advanced age is associated with chronic low-grade inflammation, which is usually referred to as inflammaging. Elderly are also known to have an altered gut microbiota composition.
Floris Fransen +19 more
doaj +1 more source
Caenorhabditis elegans and probiotics interactions from a prolongevity perspective [PDF]
, 2019 Probiotics exert beneficial effects on host health through different mechanisms of action, such as production of antimicrobial substances, competition with pathogens, enhancement of host mucosal barrier integrity and immunomodulation.
Barbara Guantario +5 more
core +1 more source
Periodontology 2000, EarlyView.Abstract Objectives Global population aging is leading to a greater retention of natural teeth into later life and an increasing prevalence of dental implant therapy. Although advanced age has traditionally been regarded as a risk factor for compromised outcomes, population level evidence remains lacking.
Dong Yang +3 more
wiley +1 more source
Changes in plasma metabolite concentrations and enzyme activities in aging riding horses
Frontiers in Veterinary ScienceIn older horses, basal metabolic rate decreases, and plasma metabolite and hormone concentrations related to energy metabolism change. The occurrence of age-related diseases, which increases in old animals, may enhance inflammatory reactivity ...
Yukari Asahi +2 more
doaj +1 more source
Charting the NF-kB pathway interactome map [PDF]
, 2010 One of the phenomena observed in human aging is the progressive increase of a systemic inflammatory state, a condition referred to as “inflammaging”, negatively correlated with longevity. The five components of the Nuclear Factor kB (NF-kB)
Alberto Termanini +4 more
core +2 more sources
Periodontology 2000, EarlyView.Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng +4 more
wiley +1 more source