Results 131 to 140 of about 18,204 (247)

Maladaptive Inflammatory Signaling in Old Mice Impairs Colonic Regeneration by Promoting a Sustained Fetal‐Like Epithelial State

Aging Cell, Volume 25, Issue 5, May 2026.
This study explores the impact of aging on regeneration of the mouse colonic epithelium. The authors find that old mice exhibit excessive and prolonged inflammation after infection with Citrobacter, resulting in the maintenance of a fetal regenerative state in epithelial cells, insufficient tissue repair, and death of the animal.
Antonion Korcari, Helen Tauc, Jeff Duggan, Jina Yun, Fabien Wehbe, Spyros Darmanis, Zora Modrusan, Rajita Pappu, David Garfield, Heinrich Jasper, David Castillo‐Azofeifa   +10 more
wiley   +1 more source

High p16INK4A expression in glioblastoma is associated with senescence phenotype and better prognosis

Neoplasia: An International Journal for Oncology Research
Glioblastoma, isocitrate dehydrogenase (IDH)-wildtype (GBM), is the most malignant brain tumor in adults, with limited therapeutic intervention. Previous studies have identified a few prognostic markers for GBM, including the methylation status of O6 ...
Soon Sang Park, Tae Hoon Roh, Yoshiaki Tanaka, Young Hwa Kim, So Hyun Park, Tae-Gyu Kim, So Yeong Eom, Tae Jun Park, In-Hyun Park, Se-Hyuk Kim, Jang-Hee Kim   +10 more
doaj   +1 more source

Decellularized Aged Bruch's Membrane Confers Unique Biochemical Cues to Retinal Pigment Epithelium for In Vitro Modeling of Age‐Related Macular Degeneration

Aging Cell, Volume 25, Issue 5, May 2026.
A Bruchs membrane (BrM) mimic based on aged decellularized BrM was developed and differentially expressed proteins in aged dECM‐BrM that may provide specific biochemical cues fundamental to model AMD in vitro were identified. RPE culture on aged dECM‐BrM developed certain AMD‐like features including reduced TEER and expression of drusen components ...
Blanca Molins, Mercedes Soledad Nabaes Jodar, Eliandre de Oliveira, Josep Maria Estanyol, Esther Peña, Jaione Bezunartea, María Hernández, Marc Figueras‐Roca, Alfredo Adan   +8 more
wiley   +1 more source

Aging‐Driven Immunosuppression: The Role of Tregs in the Ovarian Tumor Microenvironment

Aging Cell, Volume 25, Issue 5, May 2026.
In the aged ovarian TME, cancer cells exhibit increased succinate production. Elevated extracellular succinate activates the SUCNR1 receptor on Tregs, promoting their recruitment and contributing to an immunosuppressive environment. This leads to diminished anti‐tumor T cell responses and reduced survival.
Mary P. Udumula, Anjaly KM, Faraz Rashid, Mohammad Nematullah, Harshit Singh, Tanya Bhardwaj, Miriana Hijaz, Shailendra Giri, Eduardo N. Chini, Heather M. Gibson, Ramandeep Rattan   +10 more
wiley   +1 more source

Multi‐Omics Signatures of Organ Clocks in Biological Aging and Disease: A Conceptual Framework for Organ‐Specific Aging Clocks

Aging Cell, Volume 25, Issue 5, May 2026.
Organ‐specific aging clocks integrating genomics, epigenomics, transcriptomics, proteomics, and metabolomics offer a more accurate assessment of biological aging than single‐omics approaches. This review proposes a multi‐omics framework emphasizing tissue data, longitudinal study designs, and clinically meaningful training outcomes to advance the ...
Maria Vasileiou, Gabor Liposits, Bara Barakat, Nam P. Nguyen   +3 more
wiley   +1 more source

Global research trends in inflammaging from 2005 to 2024: a bibliometric analysis

Frontiers in Aging
BackgroundInflammaging, defined as chronic low-grade inflammation associated with aging, is considered a key factor in many age-related diseases. Despite growing research, comprehensive assessments of trends and focuses on this field over the past 2 ...
Beier Jiang, Beier Jiang, Yi-ni Dong, Yu Xiong, Chun-xia Jiang, Jun Ping, Qi Wu, Liu-jun Xu, Liu-jun Xu, Run-zhe Shu, Run-zhe Shu, Dan-dan Gao, Sheng-mei Zhu, Wei-dong Ye, Feng Zhang, Feng Zhang   +15 more
doaj   +1 more source

Environmental Enrofloxacin Exposure as a Modifiable Driver of Mitochondria‐Mediated Intestinal Aging and Barrier Dysfunction

Aging Cell, Volume 25, Issue 5, May 2026.
Environmentally relevant enrofloxacin accelerates intestinal aging by impairing epithelial mitochondrial function, disrupting barrier integrity, and reshaping the gut microbiota. Mitochondrial restoration with pyrroloquinoline quinone alleviates hypoxia, inflammation, and gut damage.
Kan Yu, Nengzheng Wang, Xinyi Huang, Yushu Qiu, Xuejian He, Xiaofeng Zhu, Xiaolan Zhou, Peng Yu, Gang Wei, Yan Pi, Ting Ni   +10 more
wiley   +1 more source

Characterization of age-associated inflammasome activation reveals tissue specific differences in transcriptional and post-translational inflammatory responses

Immunity & Ageing
Aging is associated with systemic chronic, low-grade inflammation, termed ‘inflammaging’. This pattern of inflammation is multifactorial and is driven by numerous inflammatory pathways, including the inflammasome.
Sarah Talley, Tyler Nguyen, Lily Van Ye, Rasa Valiauga, Jake DeCarlo, Jabra Mustafa, Benjamin Cook, Fletcher A. White, Edward M. Campbell   +8 more
doaj   +1 more source

Inflammaging: The Next Challenge—Exploring the Role of Gut Microbiota, Environmental Factors, and Sex Differences

Biomedicines
The term ‘inflammaging’ has been coined to describe the chronic state of inflammation derived from ongoing cycles of tissue damage and the subsequent immune responses.
Mario Caldarelli, Pierluigi Rio, Andrea Marrone, Vincenzo Giambra, Antonio Gasbarrini, Giovanni Gambassi, Rossella Cianci   +6 more
doaj   +1 more source

Aged Gut Microbiota Induces Mucosal Transcriptional Dysregulation, Impairing Immune Surveillance

Aging Cell, Volume 25, Issue 5, May 2026.
Aging impaired intestinal mucosal immune homeostasis by altering the epithelial barrier, lamina propria immune cells, follicle‐associated epithelium, and gut microbiota. These changes, particularly the accumulation of pro‐inflammatory bacteria in the gut microbiota, are closely associated with dysregulation of follicle‐associated epithelium gene ...
Fang Wu, Ming Zhang, Jianmin Wu, Zihan Wang, Yumeng Ma, Lin Dong, Le Cheng, Tengteng Ji, Chenyan Zheng, Fazheng Ren, Bing Fang   +10 more
wiley   +1 more source