Results 141 to 150 of about 14,164 (239)
Natural Killer Cell Dysfunction Is Emerging During Midlife Obesity
Aging Cell, Volume 25, Issue 9, September 2026.Midlife obesity was associated with impaired NK cell function, including decreased degranulation and IFN‐γ production. The loss of NK cell function might explain the greater mortality risk in middle‐aged individuals, highlighting the importance of monitoring immune alterations during midlife.
Ruojia Biao +5 more
wiley +1 more source
Mitochondrial Haplotype Shapes the Trajectory of Ovarian Aging in Genetically Heterogeneous Rats
Aging Cell, Volume 25, Issue 9, September 2026.Using genetically heterogeneous rats carrying divergent mitochondrial haplotypes on a randomized nuclear background, we show that mtDNA variation modifies the rate of ovarian aging. OKC‐HETW ovaries showed bioenergetic deficits, reduced mtDNA copy number, and impaired TFAM–mtDNA binding by 4 months of age, with early fibrosis and immune infiltration ...
Subhasri Biswas +11 more
wiley +1 more source
Clonal Mosaicism of Mitochondrial DNA Heteroplasmy as a Molecular Clock of Aging
Aging Cell, Volume 25, Issue 9, September 2026.Mitochondrial DNA mutations diverge by tissue dynamics across lifespan: dividing tissues accumulate pervasive point mutations via clonal stem‐cell expansion, whereas post‐mitotic tissues harbor clonally expanded large‐scale deletions, both culminating in age‐dependent, threshold‐limited respiratory failure.
Renin Chang +5 more
wiley +1 more source
Quantifying Information Exchange Between Cells in Inflammaging
Inflammaging is inflammation caused by altered cell–cell communications due to aging which leads to impaired wound healing. In this study, we investigated the underlying dynamics of information exchange between macrophage and fibroblast cells ...
Ibrahim, Israr B. M. +3 more
core +1 more source
Human iPSC‐Derived Brain Organoids: A Disease‐Oriented Evaluation of Modeling Fidelity
European Journal of Neuroscience, Volume 64, Issue 5, September 2026.Organoids are self‐organizing 3D structures that mimic organ architecture and function with multiple cell types arranged in spatial patterns. Brain organoids can be patterned towards specific regions and can incorporate glial and microglial components.
Bishwa R. Pokharel +6 more
wiley +1 more source
European Journal of Neuroscience, Volume 64, Issue 5, September 2026.Blood sTREM2 is emerging as a potential biomarker of neuroinflammation, yet its biological significance remains poorly understood. In this study, plasma sTREM2 was quantified in 547 individuals across Alzheimer's disease, mild cognitive impairment, multiple sclerosis, ATTR polyneuropathy, asymptomatic ATTR mutation carriers, and healthy controls ...
Luisa Agnello +10 more
wiley +1 more source
The vicious cycle of SASP and inflammaging promotes aging and age-related diseases. [PDF]
Commun BiolLiu Q, Zheng Y, Sun C.
europepmc +1 more source
A Comparative Analysis of Aging Across Causes of Death
Evolutionary Applications, Volume 19, Issue 9, September 2026.ABSTRACT Although there is huge variation in how mortality changes with age across species, in humans, all‐causes mortality increases at a relatively constant rate across populations and time. However, individuals die due to specific causes that include extrinsic and intrinsic sources. Here, we compared the rate at which mortality increases with age (i.
Gabriele Sorci, Bruno Faivre
wiley +1 more source
The Inflammation-Metabolism Axis in Preserved Ratio Impaired Spirometry: Pathogenic Mechanisms and Translational Implications. [PDF]
J Inflamm ResYuan Q +5 more
europepmc +1 more source