Results 91 to 100 of about 14,164 (239)

Inflammaging and Brain Aging

International Journal of Molecular Sciences
Progress made by the medical community in increasing lifespans comes with the costs of increasing the incidence and prevalence of age-related diseases, neurodegenerative ones included. Aging is associated with a series of morphological changes at the tissue and cellular levels in the brain, as well as impairments in signaling pathways and gene ...
Maria Carolina Jurcau, Anamaria Jurcau, Alexander Cristian, Vlad Octavian Hogea, Razvan Gabriel Diaconu, Vharoon Sharma Nunkoo   +5 more
openaire   +2 more sources

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source

Photothermal Microneedle Hydrogel Patch for Refractory Soft Tissue Injuries through Thermosensitized Anti‐Inflammaging Modulation

Small Structures
Soft tissue injuries (STIs) are the most common cause of extremity pain and motion dysfunction. Persistent inflammatory activation of immune cells characterized by senescence‐associated secretory phenotype (SASP) and mitochondrial stress are considered ...
Wanbo Zhu, Quan Liu, Ziheng Zhang, Yingjie Wang, Jiawei Mei, Dongdong Xu, Jun Zhou, Zheng Su, Xianzuo Zhang, Chen Zhu, Jiaxing Wang, Junchen Zhu, Xiaochun Peng, Xianlong Zhang   +13 more
doaj   +1 more source

Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice

Frontiers in Immunology, 2017
Advanced age is associated with chronic low-grade inflammation, which is usually referred to as inflammaging. Elderly are also known to have an altered gut microbiota composition.
Floris Fransen, Floris Fransen, Adriaan A. van Beek, Adriaan A. van Beek, Theo Borghuis, Theo Borghuis, Sahar El Aidy, Floor Hugenholtz, Floor Hugenholtz, Christa van der Gaast – de Jongh, Huub F. J. Savelkoul, Marien I. De Jonge, Mark V. Boekschoten, Mark V. Boekschoten, Hauke Smidt, Hauke Smidt, Marijke M. Faas, Marijke M. Faas, Paul de Vos, Paul de Vos   +19 more
doaj   +1 more source

The Role of Oxidative Stress in Periodontitis

Journal of Periodontal Research, EarlyView.
Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon, Francesca Giampieri, Beatriz Bullon, Maurizio Battino   +3 more
wiley   +1 more source

Inflamma-miRs in aging and breast cancer: Are they reliable players?

Frontiers in Medicine, 2015
Human aging is characterized by chronic low-grade inflammation known as inflammaging. Persistent low-level inflammation also plays a key role in all stages of breast cancer since inflammaging is the potential link between cancer and aging through NF-kB ...
Cristina Sorina Cătană, George eCalin, Ioana Berindan Neagoe, Ioana Berindan Neagoe, Ioana Berindan Neagoe   +4 more
doaj   +1 more source

Osteoporosis and Periodontitis: Two‐Way Epidemiological and Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review investigates the main mechanistic pathways connecting local periodontitis to systemic osteoporosis. Seven interconnected mechanisms are identified. ABSTRACT Osteoporosis and periodontitis are highly prevalent, chronic inflammatory diseases that constitute a major global health burden.
Jia Chang, Geeta Madhuri Bhuvanagiri, Megan Dulkanchainun, Cunyu Wang   +3 more
wiley   +1 more source

Mitochondrial (Dys) Function in Inflammaging: Do MitomiRs Influence the Energetic, Oxidative, and Inflammatory Status of Senescent Cells?

Mediators of Inflammation, 2017
A relevant feature of aging is chronic low-grade inflammation, termed inflammaging, a key process promoting the development of all major age-related diseases.
Angelica Giuliani, Francesco Prattichizzo, Luigina Micolucci, Antonio Ceriello, Antonio Domenico Procopio, Maria Rita Rippo   +5 more
doaj   +1 more source

Role of inflammaging in the development of chronic heart failure and osteoporosis: A literature review [PDF]

КардиоСоматика
The interaction between heart failure (HF) and osteoporosis in a multimorbid patient is a relevant complication in the aging population. The concept of inflammaging (inflammatory aging) allows us to consider the prolonged process of subclinical ...
Vera N. Larina, Ekaterina S. Shcherbina
doaj   +1 more source

Periodontitis and Diabetes: Mechanistic Evidence of a Circular Relationship

Journal of Periodontal Research, EarlyView.
This narrative review aimed to explore the underlying mechanisms that connect periodontitis to diabetes (and vice versa) and that influence disease susceptibility, progression and response to treatment. ABSTRACT The circular relationship between periodontitis and diabetes mellitus is one of the most established oral‐systemic links.
Philip M. Preshaw, Ren Jie Jacob Chew, Charlene Enhui Goh, Ali A. Abdulkareem, Dana T. Graves   +4 more
wiley   +1 more source