Results 61 to 70 of about 5,611 (223)

Centenarians, semi and supercentenarians, COVID-19 and Spanish flu: a serological assessment to gain insight into the resilience of older centenarians to COVID-19

Immunity & Ageing
Background Although it is well known that the older people have been the most susceptible to COVID-19, there are conflicting data on the susceptibility of centenarians.
Claudia Maria Trombetta, Giulia Accardi, Anna Aiello, Anna Calabrò, Calogero Caruso, Mattia Emanuela Ligotti, Serena Marchi, Emanuele Montomoli, Martin Mayora Neto, Nigel Temperton, Giuseppina Candore   +10 more
doaj   +1 more source

Cytometric analysis of immunosenescence [PDF]

Cytometry, 1997
We have been studying the immune system of healthy centenarians for many years, and they provide the best example of successful aging. They are people who have escaped major age-related diseases and reached the extreme limit of human life in good clinical condition.
A. Cossarizza, C. Ortolani, MONTI, DANIELA, C. Franceschi   +3 more
openaire   +4 more sources

Nanovesicles With Mechanically Induced Adjuvanticity for Robust Melanoma Vaccination Toward Tumor‐Associated Macrophages

Advanced Science, EarlyView.
Rigidity‐tunable nanovesicle (P‐Pm) with mechanically induced adjuvanticity toward tumor‐associated macrophages (TAMs) was designed to engineer R848/gp100 antigen ‐loaded nanovaccine (P@Rg‐Pm), which achieved outstanding anti‐tumor outcomes in both therapeutic and preventive model of B16‐F10 melanoma.
Bangyue Luo, Liyan Qiu
wiley   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Immunosenescence: signaling pathways, diseases and therapeutic targets

Signal Transduction and Targeted Therapy
Immunosenescence refers to the abnormal activation or dysfunction of the immune system as people age. Inflammaging is a typical pathological inflammatory state associated with immunosenescence and is characterized by excessive expression of ...
Yichu Fu, Binhan Wang, Aqu Alu, Weiqi Hong, Hong Lei, Xuemei He, Huashan Shi, Ping Cheng, Xiangliang Yang   +8 more
doaj   +1 more source

Role of zinc and selenium in oxidative stress and immunosenescence: Implications for healthy ageing and longevity

, 2009
Ageing is an inevitable biological process with gradual and spontaneous biochemical and physiological changes and increased susceptibility to diseases. Some nutritional factors (zinc and selenium) may remodel these changes leading to a possible escaping ...
Malavolta M., Mocchegiani E.
core   +1 more source

Table_1_Radiation therapy induces immunosenescence mediated by p90RSK.xlsx

, 2022
Radiation therapy (RT) to the chest increases the patients’ risk of cardiovascular disease (CVD). A complete understanding of the mechanisms by which RT induces CVD could lead to specific preventive, therapeutic approaches.
Venkata S. K. Samanthapudi (13286529), Roza Nurieva (46641), Syed Wamique Yusuf (6822308), Anita Deswal (7923626), Ling-Ling Lee (13286532), Haizi Cheng (6002156), Nicolas L. Palaskas (9637787), Steven H. Lin (7045541), John P. Cooke (259814), Keri L. Schadler (9637793), El-ad David Amir (6819107), Masaki Imanishi (515835), Sai-Ching J. Yeung (9270842), Eduardo Chini (14074563), Momoko Yoshimoto (288647), Joerg Herrmann (333656), Xiaolei Xu (81386), Cielito Reyes-Gibby (3174045), Sivareddy Kotla (5064794), Kyung Ae Ko (5064797), Nhat-Tu Le (5723063), Jun-ichi Abe (725829), Zhongxing Liao (220056), Jared K. Burks (13907542), Michihiro Kobayashi (10718499)   +24 more
core   +1 more source

Cumulative Reproductive‐Lactation Burdens Induce a Systemic Immunometabolic Trade‐Off Between Milk Yield and Mammary Health of Dairy Cows

Animal Research and One Health, EarlyView.
A population‐scale longitudinal transcriptomic atlas reveals how lactation stage and parity reshape systemic gene regulation in dairy cows. Multiomics‐inspired analyses uncover dynamic immune and metabolic adaptations that contribute to reproductive longevity and sustained productivity across the bovine lifespan.
Yangyang Shen, Zhenjiang An, Yingying Jiang, Zijian Huang, Kunlin Chen, Yundong Gao, Jianbin Li, Shuwen Xia, Huili Wang   +8 more
wiley   +1 more source

Type I Interferon Drives Dysfunction of a Distinct CD8+ HLA‐DRB1+ T Cell Subset in Systemic Lupus Erythematosus

Arthritis &Rheumatology, EarlyView.
Objective Systemic lupus erythematosus (SLE) is characterized by type I interferon (IFN) signaling and adaptive immune dysregulation. We previously identified hypomethylation of HLA‐DRB1 and STAT1 in SLE CD8+ T cells, enabling aberrant IFN‐driven HLA‐DRB1 expression and expansion of a distinct CD8+ T cell subset. This study characterized CD8+ HLA‐DRB1+
Huizhong Long, Elio Carmona, Mikhail G. Dozmorov, Amr H. Sawalha   +3 more
wiley   +1 more source

An Emerging Longevity Blue Zone in Sicily: The Case of Caltabellotta and the Sicani Mountains

Journal of Ageing and Longevity
Blue Zones (BZs) are regions across the world associated with exceptional human longevity, where individuals routinely live into their 90s and beyond. These areas share distinct lifestyle and environmental factors that promote healthy aging.
Alessandra Errigo, Giovanni Mario Pes, Calogero Caruso, Giulia Accardi, Anna Aiello, Giuseppina Candore, Sonya Vasto   +6 more
doaj   +1 more source