Results 61 to 70 of about 20,223 (261)
Experimental Gerontology, 2023 Senescent cells were recently shown to play a role in aging-related malfunctions and pathologies. This consensus has been facilitated by evidence from senolytic model mice capable of eliminating senescent cells in tissues using well-characterized ...
Yuma Sugiyama +6 more
doaj +1 more source
The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome
Biological Reviews, EarlyView.ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke +2 more
wiley +1 more source
Table_1_Radiation therapy induces immunosenescence mediated by p90RSK.xlsx
, 2022 Radiation therapy (RT) to the chest increases the patients’ risk of cardiovascular disease (CVD). A complete understanding of the mechanisms by which RT induces CVD could lead to specific preventive, therapeutic approaches.
Venkata S. K. Samanthapudi (13286529) +24 more
core +1 more source
Immunity & AgeingAging is frequently characterized by an inadequate primary vaccine response, likely due to immunosenescence and inflamm-aging, a low-level, chronic inflammatory state.
Anna Aiello +10 more
doaj +1 more source
Counting cases, conserving species: addressing highly pathogenic avian influenza in wildlife
Biological Reviews, EarlyView.ABSTRACT Highly pathogenic avian influenza (HPAI) has become a critical threat to wildlife, shifting from a seasonal epizootic to a persistent, year‐round panzootic with global consequences. Here, we summarise the origin, evolutionary mechanisms, and expanding host range of the current H5N1 virus (clade 2.3.4.4b) and assess its impact on wildlife. Over
Ulrich Knief +4 more
wiley +1 more source
, 2009 Ageing is an inevitable biological process with gradual and spontaneous biochemical and physiological changes and increased susceptibility to diseases. Some nutritional factors (zinc and selenium) may remodel these changes leading to a possible escaping ...
Malavolta M., Mocchegiani E.
core +1 more source
Immunity & AgeingBackground Although it is well known that the older people have been the most susceptible to COVID-19, there are conflicting data on the susceptibility of centenarians.
Claudia Maria Trombetta +10 more
doaj +1 more source
Robustness and Fragility in Immunosenescence
PLoS Computational Biology, 2005 We construct a model to study tradeoffs associated with aging in the adaptive immune system, focusing on cumulative effects of replacing naive cells with memory cells. Binding affinities are characterized by a stochastic shape space model. System loss arising from an individual infection is associated with disease severity, as measured by the total ...
Sean P. Stromberg, Jean M. Carlson
openaire +4 more sources
Cheek tooth extraction in geriatric versus non‐geriatric horses
Equine Veterinary Journal, EarlyView.Abstract Background Age‐related dental changes are major contributors to dental disorders in older horses, and cheek tooth extractions are often required to maintain masticatory function and oral comfort. However, limited information is available on clinical and treatment characteristics in this older patient population.
Elias Mair +4 more
wiley +1 more source
Rescuing Immunosenescence via Non-Specific Vaccination
, 2021 Discrepancies in lifespan and healthy-life span are predisposing populations to an increasing burden of age-related disease. Accumulating evidence implicates aging of the immune system, termed immunosenescence, in the pathogenesis of multiple age-related
Alexander I. Mosa, Mosa, Alexander I.
core +1 more source