Results 71 to 80 of about 20,223 (261)

Smart Nanodelivery Systems for Immunometabolic Modulation in Osteoarthritis

Exploration, EarlyView.
Smart nanodelivery systems deliver therapeutic payloads across the cartilage matrix to ensure their sustained accumulation within chondrocytes at sites of injury. By targeting specific molecular targets and signaling pathways, these platforms modulate the pathological synovium‐cartilage axis to restore immunometabolic homeostasis and drive tissue ...
Qirui Zhao, Zhewen Mi, Shuya Liu, Shijun Liang, Linjia Peng, Zixuan Gao, Jiaming Li, Xiaoqing Lu, Zhiguang Ren, Yongjie Wan, Shengsheng Cui, Longlong Lu, Xiaoyang Gao, Tao Wang, Hui Liang, Furong Tian, de la Fuente Jesus M, Chong Xiang, Luyi Sun, Lichen Xiang, Daxiang Cui   +20 more
wiley   +1 more source

Emergence of T cell immunosenescence in diabetic chronic kidney disease

Immunity & Ageing, 2020
Background Type 2 diabetes is an important challenge given the worldwide epidemic and is the most important cause of end-stage renal disease (ESRD) in developed countries.
Yen-Ling Chiu, Wan-Chuan Tsai, Ruo-Wei Hung, I-Yu Chen, Kai-Hsiang Shu, Szu-Yu Pan, Feng-Jung Yang, Te-Tien Ting, Ju-Ying Jiang, Yu-Sen Peng, Yi-Fang Chuang   +10 more
doaj   +1 more source

COPD as a Disease of Immunosenescence [PDF]

Yonsei Medical Journal, 2019
Although chronic obstructive pulmonary disease (COPD) is regarded as a chronic inflammatory lung disease, the disease mechanism is still not known. Intriguingly, aging lungs are quite similar to COPD-affected lungs in many ways, and COPD has been viewed as a disease of accelerated premature aging of the lungs.
Won-Kyung Cho, Chun Geun Lee, Lark Kyun Kim   +2 more
openaire   +3 more sources

Table_4_Radiation therapy induces immunosenescence mediated by p90RSK.XLSX

, 2022
Radiation therapy (RT) to the chest increases the patients’ risk of cardiovascular disease (CVD). A complete understanding of the mechanisms by which RT induces CVD could lead to specific preventive, therapeutic approaches.
Venkata S. K. Samanthapudi (13286529), Roza Nurieva (46641), Syed Wamique Yusuf (6822308), Anita Deswal (7923626), Ling-Ling Lee (13286532), Haizi Cheng (6002156), Nicolas L. Palaskas (9637787), Steven H. Lin (7045541), John P. Cooke (259814), Keri L. Schadler (9637793), El-ad David Amir (6819107), Masaki Imanishi (515835), Sai-Ching J. Yeung (9270842), Eduardo Chini (14074563), Momoko Yoshimoto (288647), Joerg Herrmann (333656), Xiaolei Xu (81386), Cielito Reyes-Gibby (3174045), Sivareddy Kotla (5064794), Kyung Ae Ko (5064797), Nhat-Tu Le (5723063), Jun-ichi Abe (725829), Zhongxing Liao (220056), Jared K. Burks (13907542), Michihiro Kobayashi (10718499)   +24 more
core   +1 more source

Age‐Associated Variations in Complete Blood Cell Count Parameters and Derived Indices Among Community‐Dwelling Chinese Older Adults

Journal of Clinical Laboratory Analysis, EarlyView.
This cross‐sectional study analyzed data from 9331 participants aged 24–97 to characterize age‐ and sex‐related physiological trajectories of complete blood cell count (CBC) parameters and derived inflammatory indices. Key findings encompassed age‐related declines in red blood cell and platelet counts, elevations in RDW‐CV indices and monocyte ...
Xiangyi Ma, Na Liu, Xiang Wu, Qiudan Chen, Xiaotong Chen, Qingyu Zhou, Shuying Chen, Yong Lin, Xuefeng Wang   +8 more
wiley   +1 more source

The Role of Immunosenescence in Neurodegenerative Diseases [PDF]

, 2018
Aging is characterized by the progressive decline of physiological function and tissue homeostasis leading to increased vulnerability, degeneration, and death.
Marcella Reale, Erica Costantini, Chiara D’Angelo   +2 more
core   +1 more source

Table_2_Radiation therapy induces immunosenescence mediated by p90RSK.xlsx

, 2022
Radiation therapy (RT) to the chest increases the patients’ risk of cardiovascular disease (CVD). A complete understanding of the mechanisms by which RT induces CVD could lead to specific preventive, therapeutic approaches.
Venkata S. K. Samanthapudi (13286529), Roza Nurieva (46641), Syed Wamique Yusuf (6822308), Anita Deswal (7923626), Ling-Ling Lee (13286532), Haizi Cheng (6002156), Nicolas L. Palaskas (9637787), Steven H. Lin (7045541), John P. Cooke (259814), Keri L. Schadler (9637793), El-ad David Amir (6819107), Masaki Imanishi (515835), Sai-Ching J. Yeung (9270842), Eduardo Chini (14074563), Momoko Yoshimoto (288647), Joerg Herrmann (333656), Xiaolei Xu (81386), Cielito Reyes-Gibby (3174045), Sivareddy Kotla (5064794), Kyung Ae Ko (5064797), Nhat-Tu Le (5723063), Jun-ichi Abe (725829), Zhongxing Liao (220056), Jared K. Burks (13907542), Michihiro Kobayashi (10718499)   +24 more
core   +1 more source

Immunosenescence: signaling pathways, diseases and therapeutic targets

Signal Transduction and Targeted Therapy
Immunosenescence refers to the abnormal activation or dysfunction of the immune system as people age. Inflammaging is a typical pathological inflammatory state associated with immunosenescence and is characterized by excessive expression of ...
Yichu Fu, Binhan Wang, Aqu Alu, Weiqi Hong, Hong Lei, Xuemei He, Huashan Shi, Ping Cheng, Xiangliang Yang   +8 more
doaj   +1 more source

An Emerging Longevity Blue Zone in Sicily: The Case of Caltabellotta and the Sicani Mountains

Journal of Ageing and Longevity
Blue Zones (BZs) are regions across the world associated with exceptional human longevity, where individuals routinely live into their 90s and beyond. These areas share distinct lifestyle and environmental factors that promote healthy aging.
Alessandra Errigo, Giovanni Mario Pes, Calogero Caruso, Giulia Accardi, Anna Aiello, Giuseppina Candore, Sonya Vasto   +6 more
doaj   +1 more source

Update of Immunosenescence in Cerebral Small Vessel Disease

Frontiers in Immunology, 2020
Aging of the central nervous system (CNS) is closely associated with chronic sterile low-grade inflammation in older organisms and related immune response.
Banghao Jian, Mengyan Hu, Wei Cai, Wei Cai, Bingjun Zhang, Zhengqi Lu   +5 more
doaj   +1 more source