Results 91 to 100 of about 20,223 (261)
Table_3_Radiation therapy induces immunosenescence mediated by p90RSK.xlsx
, 2022 Radiation therapy (RT) to the chest increases the patients’ risk of cardiovascular disease (CVD). A complete understanding of the mechanisms by which RT induces CVD could lead to specific preventive, therapeutic approaches.
Venkata S. K. Samanthapudi (13286529) +24 more
core +1 more source
Dasatinib and quercetin prevent alveolar bone loss in aged mice
Journal of Periodontology, EarlyView.Abstract Background Recent findings have associated alveolar bone loss (ABL) with the presence of senescent cells. Aging and the accumulation of senescent cells are associated with a pro‐inflammatory environment which may exacerbate tissue damage.
Luisa S. Battistelli +7 more
wiley +1 more source
Immunosenescence and its related comorbidities in older people living with HIV
Infectious Diseases & Immunity. With the aging of the global population, older people living with HIV (OPLWH) have emerged as a focal point in HIV/AIDS research. Although antiretroviral therapy has demonstrated positive effects in OPLWH, concerns persist regarding overall poor immune
Xiao-Yan He +10 more
doaj +1 more source
Bevacizumab‐Associated Eczema Herpeticum in Metastatic Ovarian Carcinoma: A Case Report
JEADV Clinical Practice, EarlyView.ABSTRACT Eczema herpeticum (EH) is a rare but potentially life‐threatening cutaneous infection caused by herpes simplex virus (HSV), classically associated with atopic dermatitis. Its occurrence in oncology patients receiving anti‐angiogenic targeted therapy and cytotoxic chemotherapy is exceedingly uncommon.
Mandeep Dutta Joshi +6 more
wiley +1 more source
Annual Review of Cell and Developmental Biology, 2020 Innate and adaptive immune responses decline with age, leading to greater susceptibility to infectious diseases and reduced responses to vaccines. Diseases are more severe in old than in young individuals and have a greater impact on health outcomes such as morbidity, disability, and mortality.
Daniela, Frasca +4 more
openaire +3 more sources
Staging concept for aging management: Definition, mechanism, and coping strategies
VIEW, EarlyView.We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang +6 more
wiley +1 more source
Journal of Ageing and LongevityThis study aims to characterise the B cell compartment in a cohort of Sicilian centenarians by analysing absolute CD3−CD19+ lymphocyte counts, in association with age, sex, cytomegalovirus (CMV) serostatus, related to immune ageing, and interleukin (IL ...
Giorgio Bertolazzi +8 more
doaj +1 more source
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Objective Chronic otitis media (COM) is a major public health concern, particularly in developing countries. Although complications have decreased with modern antibiotics, they still cause significant morbidity and mortality. This study analyzed the clinical features, bacteriological profiles, and treatment outcomes of COM complications at a ...
Viraporn Atchariyasathian +1 more
wiley +1 more source
Pattern Recognition Receptor Ligands as an Emerging Therapeutic Agent for Latent HIV-1 Infection
Frontiers in Cellular and Infection Microbiology, 2020 Toll-like receptors (TLRs) were first identified as molecular sensors that transduce signals from specific structural patterns derived from pathogens; their underlying molecular mechanisms of recognition and signal transduction are well-understood.
Shokichi Takahama +3 more
doaj +1 more source
Determinants of Immunoglobulin‐G N‐Glycan Patterns in the Aging General Population
Allergy, EarlyView.The effect of demographic and lifestyle factors on IgG N‐glycosylation, which determines IgG's inflammatory response, remains poorly characterized. Aging, higher BMI, female sex, smoking, and heavy alcohol consumption are determinants of IgG N‐glycome patterns, which are indicative of inflammation. Women exhibit a distinct change in IgG N‐glycosylation
Samantha Leonard +10 more
wiley +1 more source