Results 91 to 100 of about 5,611 (223)

Dysregulated Repair in Aging and Disease: Extracellular Vesicles as an Emerging Protective Strategy

Cells
Tissue repair is a finely organized process that progresses via a series of phases, including hemostasis, inflammation, proliferation, and remodeling, which are coordinated by immune–stromal interactions.
Anna Calabrò, Giulia Accardi, Alexander Batista-Duharte, Mattia Emanuela Ligotti, Alejandra Pera, Chiara Puleo, Maurizio Soresi, Giuseppina Candore, Anna Aiello   +8 more
doaj   +1 more source

Tick‐Borne Encephalitis (TBE) Vaccine in the National Immunisation Programme—For Whom, When and Where?

Acta Paediatrica, EarlyView.
ABSTRACT The incidence of Tick‐borne encephalitis (TBE) cases has increased. The presumed location of transmission of Tick‐borne encephalitis virus (TBEV) has been expanding increasingly in the western parts of Europe during the past decade. There has also been an increased incidence of surveillance‐reported TBE cases in southern Sweden and southern ...
H. H. Askling, D. Zavadska
wiley   +1 more source

The human immunosenescence phenotype: does it exist?

, 2020
'Immunosenescence' has been invoked as the root cause of increased incidence and severity of infectious disease in older adults and their poorer response to vaccination, and is implicated in increased solid cancers and increased autoimmunity with age ...
Pawelec, Graham
core   +1 more source

An immunologist's guide to immunosenescence and its treatment

, 2022
Introduction: Aging causes several changes in the immune system, although immune aging is strongly influenced by individual immunological history, as well as genetic and environmental factors leading to inter-individual variability.
Caruso, Calogero, Mattia Emanuela Ligotti, Anna Aiello, Ligotti, Mattia Emanuela, Candore, Giuseppina, Calogero Caruso, Giuseppina Candore, Aiello, Anna, Accardi, Giulia, Giulia Accardi   +9 more
core   +1 more source

Outcomes of Kaposi sarcoma in people living with HIV who maintain long‐term viral suppression: A prospective case‐series

HIV Medicine, EarlyView.
Abstract Background Data on chemotherapeutic efficacy and tolerability for Kaposi Sarcomas (KS) in people living with HIV (PWH) and HIV‐virological control are limited. We aimed to describe clinical responses and tolerability of KS therapies in PWH with HIV‐aviraemic KS in a prospective cohort.
S. Bacquart, R. Palich, M. Veyri, S. Bregigeon‐Ronot, M.‐C. Picot, C. Vidal, L. Galicier, S. Choquet, J.‐P. Spano, M.‐A. Valantin, A. Makinson   +10 more
wiley   +1 more source

Nanomedicine strategies for ameliorating cancer by targeting immunosenescence: From challenge to opportunity

Nano Research
Immunosenescence represents a natural process of immune degeneration that occurs with aging. Although this process is a common phenomenon in elderly patients, it extremely gets involved in tumor development and affects the clinical efficacy of cancer ...
Li Chen, Anqi Lin, Peng Luo, Kai Miao
doaj   +1 more source

The Causal Effect of Supra‐ and Sub‐Gingival Instrumentation on the Oral Microbiome of Elderly Periodontitis Patients Treated in Nursing Homes: Secondary Analysis of a Randomised Controlled Trial

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aims Periodontitis among nursing home residents is increasing as more older adults retain their dentition. Evidence on the impact of periodontal therapy on their oral microbiota is limited. We aimed to assess the effect of outreach‐based supra‐ and sub‐gingival instrumentation on the periodontal microbiome.
Anna Greta Barbe, Daniel Hagenfeld, Carolin Walther, Dalia Beck, Fedja Farowski, Maria J. G. T. Vehreschild, Sonja H. M. Derman, Sven Kleine Bardenhorst, Dirk Bleiel   +8 more
wiley   +1 more source

Immunosenescence in wild animals:Meta-analysis and outlook [PDF]

, 2019
Immunosenescence, the decline in immune defense with age, is an important mortality source in elderly humans but little is known of immunosenescence in wild animals.
Delhey, Kaspar, Verhulst, S., Shinichi Nakagawa, Simon Verhulst, Nakagawa, S., Verhulst, Simon; id_orcid, Peters, A., Anne Aulsebrook, Anne Peters, Peters, Anne, Verhulst, Simon, Delhey, K., Aulsebrook, A., Kaspar Delhey, Aulsebrook, Anne, Nakagawa, Shinichi   +15 more
core   +2 more sources

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source

Immunosenescence in aging and neurodegenerative diseases: evidence, key hallmarks, and therapeutic implications

Translational Neurodegeneration
Aging is a multifaceted biological process affecting various organ systems. Immunosenescence, a key feature of aging, markedly increases susceptibility to infections, cancers, autoimmune diseases, and also neurodegenerative disorders.
Zhichun Chen, Zixu Mao, Weiting Tang, Yuxuan Shi, Jun Liu, Yong You   +5 more
doaj   +1 more source