Results 101 to 110 of about 20,223 (261)

Myocardial Ischemia and Reperfusion Leads to Transient CD8 Immune Deficiency and Accelerated Immunosenescence in CMV-Seropositive Patients

, 2015
Rationale: There is mounting evidence of a higher incidence of coronary heart disease (CHD) in cytomegalovirus (CMV) seropositive individuals. Objective: The aim of this study was to investigate whether acute MI triggers an inflammatory T-cell ...
Hoffmann, Jedrzej, Pircher, Hanspeter, Alan Bagnall, Martin-Ruiz, Carmen, von Zglinicki, Thomas, Dimmick, Ian, Das, Rajiv, Karel Fiser, Boag, Stephen E, Mohaned Egred, Boag, Stephen E., Fiser, Karel, Jedrzej Hoffmann, Evgeniya V. Shmeleva, Todryk, Stephen, Carmen Martin-Ruiz, Shmeleva, Evgeniya V., Shmeleva, Evgeniya, Thomas von Zglinicki, Ian Dimmick, Murali, Santosh, Bernard Keavney, Ioakim Spyridopoulos, Santosh Murali, Stephen E. Boag, Bagnall, Alan, Shmeleva, Evgeniya V, Egred, Mohaned, Hanspeter Pircher, Rajiv Das, Keavney, Bernard, Boag, Stephen, Zglinicki, Thomas von, Stephen Todryk, Spyridopoulos, Ioakim   +34 more
core   +1 more source

Tick‐Borne Encephalitis (TBE) Vaccine in the National Immunisation Programme—For Whom, When and Where?

Acta Paediatrica, EarlyView.
ABSTRACT The incidence of Tick‐borne encephalitis (TBE) cases has increased. The presumed location of transmission of Tick‐borne encephalitis virus (TBEV) has been expanding increasingly in the western parts of Europe during the past decade. There has also been an increased incidence of surveillance‐reported TBE cases in southern Sweden and southern ...
H. H. Askling, D. Zavadska
wiley   +1 more source

Immunosenescence in HIV infection

, 2016
Immunosenescence is the progressive loss of immune tissue that result from (i) functional, (ii) clonal or (iii) systemic changes to the cells or tissue that make up the immune system.
Glenn, Wong Choon Lim, Wong Choon Lim Glenn   +1 more
core   +1 more source

Immunosenescence in wild animals:Meta-analysis and outlook [PDF]

, 2019
Immunosenescence, the decline in immune defense with age, is an important mortality source in elderly humans but little is known of immunosenescence in wild animals.
Delhey, Kaspar, Verhulst, S., Shinichi Nakagawa, Simon Verhulst, Nakagawa, S., Verhulst, Simon; id_orcid, Peters, A., Anne Aulsebrook, Anne Peters, Peters, Anne, Verhulst, Simon, Delhey, K., Aulsebrook, A., Kaspar Delhey, Aulsebrook, Anne, Nakagawa, Shinichi   +15 more
core   +1 more source

Dysregulated Repair in Aging and Disease: Extracellular Vesicles as an Emerging Protective Strategy

Cells
Tissue repair is a finely organized process that progresses via a series of phases, including hemostasis, inflammation, proliferation, and remodeling, which are coordinated by immune–stromal interactions.
Anna Calabrò, Giulia Accardi, Alexander Batista-Duharte, Mattia Emanuela Ligotti, Alejandra Pera, Chiara Puleo, Maurizio Soresi, Giuseppina Candore, Anna Aiello   +8 more
doaj   +1 more source

Understanding and addressing resistance to IMiDs immunomodulatory compounds in multiple myeloma

The FEBS Journal, EarlyView.
IMiDs are pivotal in the treatment of multiple myeloma. Mechanisms of resistance comprise cell intrinsic and extrinsic pathways, involving tumour microenvironment, immune cell dysfunction, CRBN‐dependent and independent genetic drivers and epigenetic changes.
Maria‐Cynthia Fuentes‐Lacouture, Devi Nandana, Karthik Ramasamy, Anjan Thakurta   +3 more
wiley   +1 more source

Inducing Antigen‐Specific and Functional Immune Responses in Mice Toward Bovine Herpesvirus 1 and Bovine Respiratory Syncytial Virus by Chimeric Peptides Delivered by Bovine Herpesvirus 4‐Based Vector

Immunology, EarlyView.
Bovine Alphaherpesvirus 1 (BoHV‐1) and Bovine respiratory syncytial virus (BRSV) are major drivers of respiratory disease in cattle. (A) To target both pathogens, two chimeric antigens—membrane‐linked and secreted—combining BoHV‐1 glycoprotein D and BRSV fusion glycoprotein were designed and expressed using recombinant BoHV‐4‐based vectors.
Antonino Di Lorenzo, Sergio Minesso, Chiara Cossu, Valentina Franceschi, Elisabetta Bolli, Vittorio Madia, Laura Conti, Gaetano Donofrio   +7 more
wiley   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source

Insights into vaccines for elderly individuals: from the impacts of immunosenescence to delivery strategies

npj Vaccines
Immunosenescence increases the risk and severity of diseases in elderly individuals and leads to impaired vaccine-induced immunity. With aging of the global population and the emerging risk of epidemics, developing adjuvants and vaccines for elderly ...
Yingying Hou, Min Chen, Yuan Bian, Yuan Hu, Junlan Chuan, Lei Zhong, Yuxuan Zhu, Rongsheng Tong   +7 more
doaj   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source