Results 101 to 110 of about 5,611 (223)

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Insights into vaccines for elderly individuals: from the impacts of immunosenescence to delivery strategies

npj Vaccines
Immunosenescence increases the risk and severity of diseases in elderly individuals and leads to impaired vaccine-induced immunity. With aging of the global population and the emerging risk of epidemics, developing adjuvants and vaccines for elderly ...
Yingying Hou, Min Chen, Yuan Bian, Yuan Hu, Junlan Chuan, Lei Zhong, Yuxuan Zhu, Rongsheng Tong   +7 more
doaj   +1 more source

Osteoporosis and Periodontitis: Two‐Way Epidemiological and Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review investigates the main mechanistic pathways connecting local periodontitis to systemic osteoporosis. Seven interconnected mechanisms are identified. ABSTRACT Osteoporosis and periodontitis are highly prevalent, chronic inflammatory diseases that constitute a major global health burden.
Jia Chang, Geeta Madhuri Bhuvanagiri, Megan Dulkanchainun, Cunyu Wang   +3 more
wiley   +1 more source

Oral Health, Periodontitis, and Respiratory Diseases: Biological Pathways

Journal of Periodontal Research, EarlyView.
This narrative review aims to provide a comprehensive update on the potential mechanisms by which poor oral health and periodontitis impact lung health, focusing on pneumonia, COPD, and asthma. ABSTRACT Poor oral hygiene and periodontitis influence lung diseases such as pneumonia, chronic obstructive pulmonary disease (COPD), COVID‐19, and asthma.
Raluca P. Vacaru, Andreea C. Didilescu, Frank A. Scannapieco   +2 more
wiley   +1 more source

Features of Immunosenescence in Women Newly Diagnosed With Breast Cancer

Frontiers in Immunology, 2018
Adults exposed to childhood maltreatment have increased stress reactivity. This profile is associated with dysregulation of the immune system, including enhanced inflammatory reactions and accelerated senescence.
Lauren Trintinaglia, Lauren Trintinaglia, Lucas Poitevin Bandinelli, Lucas Poitevin Bandinelli, Rodrigo Grassi-Oliveira, Rodrigo Grassi-Oliveira, Laura Esteves Petersen, Marcelo Anzolin, Bruna Luz Correa, Jaqueline Bohrer Schuch, Jaqueline Bohrer Schuch, Moisés Evandro Bauer, Moisés Evandro Bauer, Moisés Evandro Bauer   +13 more
doaj   +1 more source

Research Progress on Immunosenescence in Elderly Patients 
with Advanced Non-small Cell Lung Cancer and Its Immunotherapy

Chinese Journal of Lung Cancer
Lung cancer remains the leading cause of cancer-related incidence and mortality worldwide. Among its histological subtypes, non-small cell lung cancer (NSCLC) accounts for the majority of cases, representing the predominant pathological type. Notably, in
Na WANG, Yaning LUO, Haoyu LU, Siyuan CUI, Kui ZHAO, Fanming KONG   +5 more
doaj   +1 more source

Hallmarks of human “immunosenescence”: adaptation or dysregulation? [PDF]

, 2012
Is immunosenescence an intrinsic ageing process leading to dysregulation of immunity or an adaptive response of the individual to pathogen exposure? Age-associated differences in bone marrow immune cell output and thymic involution suggest the former ...
Pawelec Graham, Graham Pawelec
core   +1 more source

Genetic risk variants implicate impaired maintenance and repair of periodontal tissues as causal for periodontitis—A synthesis of recent findings

Periodontology 2000, EarlyView.
AbstractPeriodontitis is a complex inflammatory disease in which the host genome, in conjunction with extrinsic factors, determines susceptibility and progression. Genetic predisposition is the strongest risk factor in the first decades of life. As people age, chronic exposure to the periodontal microbiome puts a strain on the proper maintenance of ...
Arne S. Schaefer, Luigi Nibali, Noha Zoheir, Niki M. Moutsopoulos, Bruno G. Loos   +4 more
wiley   +1 more source

Turning to immunosuppressive tumors: Deciphering the immunosenescence-related microenvironment and prognostic characteristics in pancreatic cancer, in which GLUT1 contributes to gemcitabine resistance

Heliyon
Increasing evidence indicates that the remodeling of immune microenvironment heterogeneity influences pancreatic cancer development, as well as sensitivity to chemotherapy and immunotherapy.
Si-Yuan Lu, Qiong-Cong Xu, De-Liang Fang, Yin-Hao Shi, Ying-Qin Zhu, Zhi-De Liu, Ming-Jian Ma, Jing-Yuan Ye, Xiao Yu Yin   +8 more
doaj   +1 more source

Determinants of Total and Inhaled Allergen‐Specific Immunoglobulin E in the Middle‐Aged and Elderly Population

Clinical &Experimental Allergy, EarlyView.
M. Al Fatly, S. Leonard, P.L.A. van Daele, G. Helleman, E. Torabi‐Azhandeh, L. Lahousse, S. Veenbergen, L. Chaker   +7 more
wiley   +1 more source