Results 111 to 120 of about 29,526 (256)

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Groeger Sabine Elisabeth, Zhou Yuxi, Yong Jiawen, Wang Lei, Ruf Sabine, Meyle Joerg   +5 more
wiley   +1 more source

Features of Immunosenescence in Women Newly Diagnosed With Breast Cancer

Frontiers in Immunology, 2018
Adults exposed to childhood maltreatment have increased stress reactivity. This profile is associated with dysregulation of the immune system, including enhanced inflammatory reactions and accelerated senescence.
Lauren Trintinaglia, Lauren Trintinaglia, Lucas Poitevin Bandinelli, Lucas Poitevin Bandinelli, Rodrigo Grassi-Oliveira, Rodrigo Grassi-Oliveira, Laura Esteves Petersen, Marcelo Anzolin, Bruna Luz Correa, Jaqueline Bohrer Schuch, Jaqueline Bohrer Schuch, Moisés Evandro Bauer, Moisés Evandro Bauer, Moisés Evandro Bauer   +13 more
doaj   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Immunosenescence in HIV Pathogenesis

Virology, 1997
Telomeres are complex protein-DNA structures located at the ends of eukaryotic chromosomes. In a normal cell, telomere DNA shortens with cell divisions. Such a telomere loss may act as a mitotic clock to eventually signal cell cycling exit and cellular senescence. In a transversal study, we found a marked decrease in telomere length of peripheral blood
Pommier, Jean-Patrick, Gauthier, Laurent, Livartowski, Joêl, Galanaud, Pierre, Boué, François, Dulioust, Anne, Marcé, Dominique, Ducray, Caroline, Sabatier, Laure, Lebeau, Jérôme, Boussin, François-Dominique   +10 more
openaire   +2 more sources

Research Progress on Immunosenescence in Elderly Patients 
with Advanced Non-small Cell Lung Cancer and Its Immunotherapy

Chinese Journal of Lung Cancer
Lung cancer remains the leading cause of cancer-related incidence and mortality worldwide. Among its histological subtypes, non-small cell lung cancer (NSCLC) accounts for the majority of cases, representing the predominant pathological type. Notably, in
Na WANG, Yaning LUO, Haoyu LU, Siyuan CUI, Kui ZHAO, Fanming KONG   +5 more
doaj   +1 more source

Turning to immunosuppressive tumors: Deciphering the immunosenescence-related microenvironment and prognostic characteristics in pancreatic cancer, in which GLUT1 contributes to gemcitabine resistance

Heliyon
Increasing evidence indicates that the remodeling of immune microenvironment heterogeneity influences pancreatic cancer development, as well as sensitivity to chemotherapy and immunotherapy.
Si-Yuan Lu, Qiong-Cong Xu, De-Liang Fang, Yin-Hao Shi, Ying-Qin Zhu, Zhi-De Liu, Ming-Jian Ma, Jing-Yuan Ye, Xiao Yu Yin   +8 more
doaj   +1 more source

T Cell Immunosenescence after Early Life Adversity: Association with Cytomegalovirus Infection

Frontiers in Immunology, 2017
Early life adversity (ELA) increases the risk for multiple age-related diseases, such as diabetes type 2 and cardiovascular disease. As prevalence is high, ELA poses a major and global public health problem.
Martha M. C. Elwenspoek, Martha M. C. Elwenspoek, Krystel Sias, Xenia Hengesch, Violetta K. Schaan, Fleur A. D. Leenen, Fleur A. D. Leenen, Philipp Adams, Sophie B. Mériaux, Stephanie Schmitz, Fanny Bonnemberger, Anouk Ewen, Hartmut Schächinger, Claus Vögele, Claude P. Muller, Claude P. Muller, Jonathan D. Turner   +16 more
doaj   +1 more source

Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice. [PDF]

, 2019
BackgroundAlzheimer disease (AD) is characterized by the accumulation of beta-amyloid (Aβ) plaques and neurofibrillary tangles composed of hyperphosphorylated tau, which together lead to neurodegeneration and cognitive decline.
Agadjanyan, Michael G, Antonyan, Tatevik, Blurton-Jones, Mathew, Chailyan, Gor, Coburn, Morgan A, Cribbs, David H, Danhash, Emma, Davtyan, Hayk, Ghochikyan, Anahit, Hovakimyan, Armine, Kiani Shabestari, Sepideh, Petrovsky, Nikolai, Petrushina, Irina, Svystun, Olga, Zagorski, Karen   +14 more
core  

Genetic risk variants implicate impaired maintenance and repair of periodontal tissues as causal for periodontitis—A synthesis of recent findings

Periodontology 2000, EarlyView.
AbstractPeriodontitis is a complex inflammatory disease in which the host genome, in conjunction with extrinsic factors, determines susceptibility and progression. Genetic predisposition is the strongest risk factor in the first decades of life. As people age, chronic exposure to the periodontal microbiome puts a strain on the proper maintenance of ...
Arne S. Schaefer, Luigi Nibali, Noha Zoheir, Niki M. Moutsopoulos, Bruno G. Loos   +4 more
wiley   +1 more source

Bone biology in aging periodontal and peri‐implant tissues

Periodontology 2000, EarlyView.
Abstract Background Periodontal disease is an age‐related chronic inflammatory condition leading to tooth loss. Dental implants are an option for replacement of lost teeth in older adults. However, age‐related changes to alveolar bone may have pathological implications for its role in supporting the dentition and dental implants.
Dalia Rasheed Issa, Giuseppe Intini, Daniel Clark   +2 more
wiley   +1 more source