Results 111 to 120 of about 20,223 (261)

Osteoporosis and Periodontitis: Two‐Way Epidemiological and Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review investigates the main mechanistic pathways connecting local periodontitis to systemic osteoporosis. Seven interconnected mechanisms are identified. ABSTRACT Osteoporosis and periodontitis are highly prevalent, chronic inflammatory diseases that constitute a major global health burden.
Jia Chang, Geeta Madhuri Bhuvanagiri, Megan Dulkanchainun, Cunyu Wang   +3 more
wiley   +1 more source

Features of Immunosenescence in Women Newly Diagnosed With Breast Cancer

Frontiers in Immunology, 2018
Adults exposed to childhood maltreatment have increased stress reactivity. This profile is associated with dysregulation of the immune system, including enhanced inflammatory reactions and accelerated senescence.
Lauren Trintinaglia, Lauren Trintinaglia, Lucas Poitevin Bandinelli, Lucas Poitevin Bandinelli, Rodrigo Grassi-Oliveira, Rodrigo Grassi-Oliveira, Laura Esteves Petersen, Marcelo Anzolin, Bruna Luz Correa, Jaqueline Bohrer Schuch, Jaqueline Bohrer Schuch, Moisés Evandro Bauer, Moisés Evandro Bauer, Moisés Evandro Bauer   +13 more
doaj   +1 more source

The human immunosenescence phenotype: does it exist?

, 2020
'Immunosenescence' has been invoked as the root cause of increased incidence and severity of infectious disease in older adults and their poorer response to vaccination, and is implicated in increased solid cancers and increased autoimmunity with age ...
Pawelec, Graham
core   +1 more source

Research Progress on Immunosenescence in Elderly Patients 
with Advanced Non-small Cell Lung Cancer and Its Immunotherapy

Chinese Journal of Lung Cancer
Lung cancer remains the leading cause of cancer-related incidence and mortality worldwide. Among its histological subtypes, non-small cell lung cancer (NSCLC) accounts for the majority of cases, representing the predominant pathological type. Notably, in
Na WANG, Yaning LUO, Haoyu LU, Siyuan CUI, Kui ZHAO, Fanming KONG   +5 more
doaj   +1 more source

Genetic risk variants implicate impaired maintenance and repair of periodontal tissues as causal for periodontitis—A synthesis of recent findings

Periodontology 2000, EarlyView.
AbstractPeriodontitis is a complex inflammatory disease in which the host genome, in conjunction with extrinsic factors, determines susceptibility and progression. Genetic predisposition is the strongest risk factor in the first decades of life. As people age, chronic exposure to the periodontal microbiome puts a strain on the proper maintenance of ...
Arne S. Schaefer, Luigi Nibali, Noha Zoheir, Niki M. Moutsopoulos, Bruno G. Loos   +4 more
wiley   +1 more source

Turning to immunosuppressive tumors: Deciphering the immunosenescence-related microenvironment and prognostic characteristics in pancreatic cancer, in which GLUT1 contributes to gemcitabine resistance

Heliyon
Increasing evidence indicates that the remodeling of immune microenvironment heterogeneity influences pancreatic cancer development, as well as sensitivity to chemotherapy and immunotherapy.
Si-Yuan Lu, Qiong-Cong Xu, De-Liang Fang, Yin-Hao Shi, Ying-Qin Zhu, Zhi-De Liu, Ming-Jian Ma, Jing-Yuan Ye, Xiao Yu Yin   +8 more
doaj   +1 more source

T Cell Immunosenescence after Early Life Adversity: Association with Cytomegalovirus Infection

Frontiers in Immunology, 2017
Early life adversity (ELA) increases the risk for multiple age-related diseases, such as diabetes type 2 and cardiovascular disease. As prevalence is high, ELA poses a major and global public health problem.
Martha M. C. Elwenspoek, Martha M. C. Elwenspoek, Krystel Sias, Xenia Hengesch, Violetta K. Schaan, Fleur A. D. Leenen, Fleur A. D. Leenen, Philipp Adams, Sophie B. Mériaux, Stephanie Schmitz, Fanny Bonnemberger, Anouk Ewen, Hartmut Schächinger, Claus Vögele, Claude P. Muller, Claude P. Muller, Jonathan D. Turner   +16 more
doaj   +1 more source

Bone biology in aging periodontal and peri‐implant tissues

Periodontology 2000, EarlyView.
Abstract Background Periodontal disease is an age‐related chronic inflammatory condition leading to tooth loss. Dental implants are an option for replacement of lost teeth in older adults. However, age‐related changes to alveolar bone may have pathological implications for its role in supporting the dentition and dental implants.
Dalia Rasheed Issa, Giuseppe Intini, Daniel Clark   +2 more
wiley   +1 more source

Population level data on aging in periodontal and peri‐implant health—Aging is not a contraindication for periodontal or peri‐implant therapy

Periodontology 2000, EarlyView.
Abstract Objectives Global population aging is leading to a greater retention of natural teeth into later life and an increasing prevalence of dental implant therapy. Although advanced age has traditionally been regarded as a risk factor for compromised outcomes, population level evidence remains lacking.
Dong Yang, Jia Chang, Siyu Huang, Yvonne L. Kapila   +3 more
wiley   +1 more source

Sonidegib efficacy and safety in ultra‐nonagenarian patients

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Camilla Brunello, Andrea Corio, Marco Zanette, Raffaele Dante Caposiena Caro, Iris Zalaudek, Nicola di Meo   +5 more
wiley   +1 more source