Results 131 to 140 of about 20,223 (261)

DAMPs in immunosenescence and cancer

Seminars in Cancer Biology
Damage-associated molecular patterns (DAMPs) are endogenous molecules released by cells in response to injury or stress, recognized by host pattern recognition receptors that assess the immunological significance of cellular damage. The interaction between DAMPs and innate immune receptors triggers sterile inflammation, which serves a dual purpose ...
Fangquan, Chen, Hu, Tang, Xiutao, Cai, Junhao, Lin, Rui, Kang, Daolin, Tang, Jiao, Liu   +6 more
openaire   +2 more sources

Born early, age fast: Consequences of premature birth on chronic disease and accelerated ageing

The Journal of Physiology, EarlyView.
Abstract figure legend ELGANs are exposed to several postnatal pro‐oxidant stressors, including ambient and supplemental oxygen, mechanical ventilation, infections, hyperalimentation, excessive glucocorticoids and intermittent hypoxia. Since endogenous antioxidant defences are underdeveloped, this imbalance promotes oxidative stress and inflammation ...
Estelle B. Gauda, Julijana Ivanovska, Dwayne Mascarenhas, Jeffrey Antwi, Atefeh Mohammadi, Bonny Jasani   +5 more
wiley   +1 more source

The pathophysiological mechanisms of immunosenescence in coronary artery disease

Frontiers in Cell and Developmental Biology
Coronary artery disease (CAD) is the most common coronary heart disease, characterized by the accumulation of atherosclerotic plaques in the coronary arteries, which supply oxygen and nutrients to the heart.
Hengjie Bie, Zhengxian Tao
doaj   +1 more source

Cross‐Level Regulatory Interactions Underlying Human Immune Aging

MedComm, Volume 7, Issue 7, July 2026.
We performed multi‐omics sequencing on peripheral blood samples from 69 individuals aged 23–75 years and identified multi‐layered molecular interaction networks underlying the process of immune senescence, which provides a comprehensive multi‐omics framework for understanding immune aging and identifying potential strategies to delay immunosenescence ...
Quanyou Wu, Botao Zhang, Xiaochen Zhi, Qi Zhang, Kai Zhang, Yaru Wang, Kaitai Zhang, Lin Feng, Shujun Cheng, Ting Xiao   +9 more
wiley   +1 more source

Neurocognitive Aging Following Acute Illness: Pathobiology and a Framework for Developing Neurotherapeutic Agents

Brain and Behavior, Volume 16, Issue 6, June 2026.
In this review, we discuss the scientific basis for how neurocognitive aging occurs after critical illness, including sepsis, trauma, and burns, and the clinical need to develop therapies to reduce inflammation, protect the blood–brain barrier, remove senescent cells, and enhance neuroplasticity.
Errin Lawrence, Daniel Fulton, Poppy Brown, Subashini Suresh, Mark Morris, Paraskevi Goggolidou, Sree Chaithanya, Marcus Abbawy, Amelia Wild, Prashant Nasa, Niharika A. Duggal, Fang Gao‐Smith, Zubair Ahmed, Suresh Renukappa, Tonny Veenith   +14 more
wiley   +1 more source

Exploring the High‐Risk Factors of Gastric “Inflammatory Cancer Transformation” Based on Inflammatory Immune Response: Construction of RHPI Complicated With CAG Risk Prediction Model

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Objective To investigate risk factors for refractory Helicobacter pylori infection (RHPI) complicated by chronic atrophic gastritis (CAG) and to develop a risk prediction model for early identification of high‐risk patients. Methods A retrospective cohort study enrolled 367 RHPI patients from January 2015 to December 2024.
Tian‐tong Jiang, Liu‐feng Yi, Ya‐xuan Wang, Shao‐li Wang, Yan‐Jiao Zhang, Zhi‐hua Tian, Xin‐qiao Chu, Jing‐yu Chen, Yi Luo, Nan Luo, Zhen Liu   +10 more
wiley   +1 more source

Immunosenescence: Aging and Immune System Decline

Immunosenescence, a systematic reduction in the immune system connected with age, profoundly affects the health and well-being of elderly individuals.
Priyanka Goyani, Rafail Christodoulou, Evros Vassiliou   +2 more
core   +1 more source

Vitamin D receptor signaling in inflammatory senescence–associated skin aging: Mechanisms and therapeutic potentials

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Vitamin D receptor (VDR) signaling is implicated in inflammatory senescence‐associated skin aging, a growing health concern in aging populations where cellular senescence and chronic inflammation converge to create complex pathophysiological conditions.
Liancheng Guan, Fan Yang, Meijuan Li, Yujia Chen, Zexin Zhao, Hongxia Li, Deping Luo, Qian Li, Yunzhi Chen   +8 more
wiley   +1 more source

Tacrolimus as Single‐Agent Immunotherapy for Adult‐Onset Myasthenia Gravis: Remission, Relapse, and Safety

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Tacrolimus monotherapy yields high remission in adult‐onset MG, especially in new‐onset or younger patients. Relapse is linked to low tacrolimus concentration and rapid tapering. Hyperglycemia was the most common ADR. Long‐term use may increase cancer risk.
Zhangyan Geng, Yuting Jiang, Nairong Xie, Wenjia Zhu, Hai Chen, Yaye Wang, Haoran Liu, Qinyao Liu, Congwen Lv, Yu Qian, Yan Lu, Li Di, Min Wang, Min Xu, Xinmei Wen, Bingchuan Xie, Yuwei Da   +16 more
wiley   +1 more source

Hallmarks of human “immunosenescence”: adaptation or dysregulation?

, 2012
Is immunosenescence an intrinsic ageing process leading to dysregulation of immunity or an adaptive response of the individual to pathogen exposure? Age-associated differences in bone marrow immune cell output and thymic involution suggest the former ...
Pawelec Graham, Graham Pawelec
core   +1 more source