Results 151 to 160 of about 20,223 (261)

CMV and Immunosenescence: from basics to clinics

Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people.
Pawelec, Graham, Frasca, Daniela, Hurme, Mikko, Nikolich Zugich, Janko, Grubeck Loebenstein, Beatrix, Pera, Alejandra, Akbar, Arne N, Wang, George C, Hill, Ann, Campos, Carmen, Derhovanessian, Evelyna, Sauce, Delphine, Beswick, Mark, Naumova, Elissaveta, López-Botet, Miguel, Wills, Mark R, Fulöp, Tamas, Ferrando Martínez, Sara, McElhaney, Janet E, Kern, Florian, Riddell, Natalie, Tarazona, Raquel, Aiello, Allison E, Govind, Sheila, Sanchez Correa, Beatriz, Larbi, Anis, Bosch, Jos A, Moss, Paul, Sansoni, Paolo, Zielinski, Maciej, Cicin Sain, Luca, Lier, Rene van, Solana, Rafael, Cantisán, Sara, Rector, Jerrarld L, Maier, Andrea B, Appay, Victor   +36 more
core  

Unraveling Oral Dysbiosis: Microbial Complexity in Common Oral Diseases

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
The oral microbiome undergoes dynamic establishment from birth, maturing into a resilient ecosystem. Perturbation of this homeostasis—driven by dietary, immunological, and anatomical factors—triggers dysbiosis, which underpins the pathogenesis of major oral diseases, including dental caries, periodontal disease, salivary gland disorders, oral mucosal ...
Zixi Kang, Hong Huang, Jin Lin, Yanan Niu, Jiaxin Chen, Jiaxuan Tang, Zhengyuan Hu, Peng Liu, Jun Qu   +8 more
wiley   +1 more source

Coxiella burnetii Infection Among Blood Donors From Baden‐Wuerttemberg Province and Hesse Province, Germany: A Multicentre Cross‐Sectional Serological Study

Public Health Challenges, Volume 5, Issue 2, June 2026.
This study analyzes the seroprevalence of Coxiella burnetii in a German non‐risk population using a stratified sampling approach across two federal states (n = 8400 potential samples). Screening of over 5000 blood donors reveals an overall seroprevalence of 2.96%.
Larissa Dangel, Daniela Hummel, Volkhard A. J. Kempf, Mirko Faber, Kai Hourfar, Brockmann Stefan, Martin Eichner, Silke F. Fischer   +7 more
wiley   +1 more source

Association of Body Mass Index with SARS‐CoV‐2 Infection in Inflammatory Arthritis Patients Receiving Biologic Therapy: Singapore National Biologics Register Findings

International Journal of Rheumatic Diseases, Volume 29, Issue 6, June 2026.
ABSTRACT Purpose To determine the association of body mass index (BMI) with incident COVID‐19 infection in patients with inflammatory arthritis (IA) using biologic disease‐modifying anti‐rheumatic drugs (bDMARDs) and targeted synthetic DMARDs (tsDMARDs) and to describe characteristics of patients with severe COVID‐19 infection. Methods This prospective
Preeti Dhanasekaran, Siaw Ing Yeo, Yi Xin Ng, Rosa Lim, Stephanie Wong, Stanley Angkodjojo, Andrew Yu Keat Khor, Li Wearn Koh, Manjari Lahiri, Margaret Ma   +9 more
wiley   +1 more source

Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults—A Pilot Study

Aging Cell, Volume 25, Issue 6, June 2026.
Can we boost vaccine responses in older adults? In a double‐blind, randomised, placebo‐controlled pilot study (n = 40, > 65 years), spermidine supplementation (6 mg/day, 13 weeks) was safe and significantly improved immune responses following a 3rd SARS‐CoV‐2 vaccine dose.
Ghada Alsaleh, Mohammad Ali, Amir Hossein Kayvanjoo, Feng Liu, Tanaïs Moreau, Sagida Bibi, Lin Luo, Melissa Govender, Miles Carroll, Sebastian J. Hofer, Eisenberg Tobias, Christoph Magnes, Loren Kell, Christopher Chung, Yu Deng, Aneesha Bhandari, Lucy Garner, Thomas Conrad, Liye Chen, Barbara Kronsteiner‐Dobramysl, Susie Dunachie, Owen B. Spiller, Teresa Lambe, Paul Klenerman, Lucy C. Jones, A. Katharina Simon   +25 more
wiley   +1 more source

Immunosenescence in multiple sclerosis: New insights and clinical implications

Aging is associated with profound changes in cellular function (senescence) and affects various tissues and systems, including the immune system (immunosenescence). Despite the increasing average age of individuals with multiple sclerosis (MS), little is
Tiziana Vigo, Antonio Uccelli, Alice Laroni, Matilde Inglese   +3 more
core   +1 more source

Vascular Immune Remodeling: A CD4+ T Cell–Driven Immune Trajectory Associated With Arterial Stiffness

Aging Cell, Volume 25, Issue 6, June 2026.
This study integrated arterial stiffness with peripheral TCRβ repertoire and single‐cell transcriptomics in adults without cardiovascular disease, revealing a CD4+ T cell–driven “vascular immune remodeling” trajectory distinct from classical immunosenescence: increased TCR diversity, broad expansion of low‐frequency public clones and virus‐associated ...
Yu Miao, Bangwei Chen, Changqing Zeng, Xiaofen Wu, Minglei Yang, Cuntai Zhang, Jianguo Zhang, Yutao Du, Tao Li, Lei Ruan   +9 more
wiley   +1 more source

Editorial: Immunosenescence and metabolic reprogramming in aging: mechanistic insights and interventions. [PDF]

Front Cell Dev Biol
Zhu T, Jiang H, Zhou Z, Xu R, Zhu X, Li W.   +5 more
europepmc   +1 more source

The Aging Microenvironment Shapes Angiogenic Remodeling in IBD‐Associated Colorectal Carcinogenesis

Aging Cell, Volume 25, Issue 6, June 2026.
In IBD, chronic inflammation promotes cellular senescence across epithelial, stromal, endothelial, and immune compartments. The resulting SASP drives pathological angiogenesis, vascular dysfunction, hypoxia, and immune suppression, thereby facilitating progression from inflammation to dysplasia and colitis‐associated colorectal cancer.
Ruoshu Duan, Qingyu Chen, Yuan Xu, Ye Yan, Sujing Jiang   +4 more
wiley   +1 more source

Immunosenescence and Bone Homeostasis: From Mechanisms of Homeostasis Disruption to Therapeutic Opportunities in Age-Related Skeletal Disorders. [PDF]

Int J Mol Sci
Jiang F, Dong B, Wang Y, Xiong Y.
europepmc   +1 more source