Results 151 to 160 of about 5,611 (223)

Dermatome‐Specific Herpes Zoster Following Corticosteroid Therapy for Lumbar Disc Herniation: A Case Report Illustrating the Immunocompromised District Theory

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Systemic corticosteroids frequently utilized to manage lumbosacral radiculopathy introduce an immunological paradox by potentially triggering varicella‐zoster virus reactivation. While well‐documented in severely immunocompromised populations, the specific neuro‐immunological mechanisms in otherwise immunocompetent patients with lumbar disc ...
Jun Liu, Lili Luo, Ming Zhou, Weifeng Chen, Na Cao, Zhanglin Pu, Yunwei Niu, Jiachen Guo, Huayuan Liao, Yi Li, Jun Gao, Kang Wei   +11 more
wiley   +1 more source

Venetoclax for elderly patients with acute myeloid leukaemia unfit for intensive chemotherapy: Prospects, resistance mechanisms and management strategies

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Resistance to venetoclax has become a critical bottleneck limiting its long‐term clinical benefits. A thorough understanding of the underlying resistance mechanisms and the development of novel strategies to overcome resistance are central to improving survival outcomes in elderly AML patients. Abstract To date, the treatment of acute myeloid leukaemia
Jinlin Zhang, Jile Liu, Mohan Zhao, Xiaoyu Zhang, Linlin Liu, Mengnan Li, Changze Cao, Rui Zhang, Mingfeng Zhao   +8 more
wiley   +1 more source

Tryptophan metabolism in colorectal cancer: From mechanistic insights to novel therapeutic strategies

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Tryptophan metabolism modulates CRC via three microbiota‐regulated pathways with distinct dual‐mode effects. The kynurenine pathway provides biomarkers, serotonin pathway supports SSRI‐combined immunotherapy, indole pathway yields immunostimulatory metabolites, collectively offering translational prospects.
Ran Wang, Wenke Shen, Ping Yang, Dongxue Yang, Yuepeng Cao, Yuping Zhou   +5 more
wiley   +1 more source

Exercise Ameliorates Immunosenescence: From Mechanisms to Interventions

Aging is an inevitable biological process that affects the function of various organs, including the immune system. Immunosenescence is characterized by diminished immune cell function, weakened immune responses, and imbalances in immune components ...
Jianchang Ren, Haili Xiao
core   +1 more source

Host Fitness: A Missing Dimension of Precision Medicine in Older Acute Myeloid Leukemia

Hematological Oncology, Volume 44, Issue 5, September 2026.
ABSTRACT The therapeutic landscape for older adults with acute myeloid leukemia (AML) has undergone a major paradigm shift with the advent of lower‐intensity targeted regimens, particularly hypomethylating agents combined with venetoclax. As treatment transitions from acute induction to prolonged, multi‐cycle administration, clinical success ...
Fortunato Morabito, Antonella Bruzzese, Enrica Antonia Martino, Nicola Amodio, Ernesto Vigna, Massimo Gentile   +5 more
wiley   +1 more source

Miliary Tuberculosis Diagnosed After Repeated Sputum Smear Examinations Despite Negative Results at a Referral Tuberculosis Center: The Importance of Maintaining Clinical Suspicion

Journal of General and Family Medicine, Volume 27, Issue 5, September 2026.
ABSTRACT An 88‐year‐old woman with back pain was found to have destructive changes at T9/T10 and diffuse micronodular pulmonary opacities suggestive of miliary tuberculosis. At two referring hospitals, six sputum smears and two interferon‐gamma release assays were negative.
Kento Kabeya, Kousuke Mouri, Hidehiro Someko   +2 more
wiley   +1 more source

DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy

MedComm, Volume 7, Issue 9, September 2026.
This review synthesizes the expanding biology of PAMPs and DAMPs, from their molecular sources and sensing mechanisms to regulatory networks that govern inflammation and homeostasis. Spanning from classical immune activation to trained immunity and interorgan communication, we highlight the interplay between PAMPs and DAMPs and their context‐dependent ...
Xuanxuan Yu, Yuqin Jin, Baochao Li, Jie Deng, Yiwen Zhou, Jinglun Zhang, Huang Li   +6 more
wiley   +1 more source

Ergothioneine: Biosynthesis, Molecular Mechanisms, Physiological Function, and Role in Disease

MedComm, Volume 7, Issue 9, September 2026.
Ergothioneine is a natural thione antioxidant with significant biomedical potential. By reducing oxidative stress, inflammation, mitochondrial dysfunction, and cellular injury, ergothioneine may support interventions for aging‐related disorders, neurodegeneration, metabolic diseases, and skin protection.
Guojuan Yi, Dongping Yao, Chanjuan Dong, Xiao Tu, Guojian Liao, Mengfei Long, Yongmei Xie   +6 more
wiley   +1 more source

Cytokine Profiles in Myasthenia Gravis Subgroups and the Lack of Any Effect of Immunosuppression

Muscle &Nerve, Volume 74, Issue S1, Page S142-S149, September 2026.
ABSTRACT Introduction/Aims Myasthenia gravis (MG) is a clinically and immunologically heterogeneous autoimmune disease and there is little known about the differential effects of cytokines in disease subgroups. This study aimed to compare serum cytokine profiles across distinct MG subgroups, including early‐onset MG (EOMG), late‐onset MG (LOMG), muscle‐
Merve Cebi, Hacer Durmus, Arman Çakar, Mehmet Güven Günver, Yesim Parman, Feza Deymeer, Güher Saruhan‐Direskeneli   +6 more
wiley   +1 more source

Gastrointestinal Parasites of Domestic Ducks (Anas platyrhynchos domesticus) in Kathmandu, Nepal

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
Gastrointestinal parasites in ducks raised on smallholder farms in Kathmandu, Nepal, are investigated using copromicroscopic examination. A diverse range of protozoa and helminth parasites are detected including the first records of Entamoeba spp., Cryptosporidium sp. and Tyzzeria sp. in ducks in Nepal.
Priyanka Mandal, Roshan Babu Adhikari, Tirth Raj Ghimire   +2 more
wiley   +1 more source