Results 141 to 150 of about 5,611 (223)

The discovery of Regulatory T Cells: a long journey toward immune balance and Nobel Prize [PDF]

Exploration of Immunology
Anna Calabrò, Calogero Caruso
doaj   +1 more source

Therapeutic Immune Reprogramming by Rapamycin Attenuates Plaque Inflammation and Lymphoid Immune Responses in Aged Atherosclerotic Mice

Aging Cell, Volume 25, Issue 10, October 2026.
Rapamycin exerts multifaceted immunomodulatory effects in age‐induced atherosclerosis, with pronounced inhibitory effects on adaptive immunity. Rapamycin reduced plaque inflammation and macrophage content, diminished pro‐inflammatory T cell responses, lowered age‐associated B cell frequencies, and attenuated senescence‐associated immune signatures ...
Jill de Mol, Daphne H. de Korte, Marie A. C. Depuydt, Virginia Smit, Mireia N. A. Bernabé Kleijn, Peter J. van Santbrink, Christoph J. Binder, Florentina Porsch, Frank H. Schaftenaar, Amanda C. Foks   +9 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, Volume 20, Issue 9, Page 2340-2355, September 2026.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, Volume 7, Issue 3, Page 99-108, September 2026.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

CMV and Immunosenescence: from basics to clinics

Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people.
Pawelec, Graham, Frasca, Daniela, Hurme, Mikko, Nikolich Zugich, Janko, Grubeck Loebenstein, Beatrix, Pera, Alejandra, Akbar, Arne N, Wang, George C, Hill, Ann, Campos, Carmen, Derhovanessian, Evelyna, Sauce, Delphine, Beswick, Mark, Naumova, Elissaveta, López-Botet, Miguel, Wills, Mark R, Fulöp, Tamas, Ferrando Martínez, Sara, McElhaney, Janet E, Kern, Florian, Riddell, Natalie, Tarazona, Raquel, Aiello, Allison E, Govind, Sheila, Sanchez Correa, Beatriz, Larbi, Anis, Bosch, Jos A, Moss, Paul, Sansoni, Paolo, Zielinski, Maciej, Cicin Sain, Luca, Lier, Rene van, Solana, Rafael, Cantisán, Sara, Rector, Jerrarld L, Maier, Andrea B, Appay, Victor   +36 more
core  

Engineering Human Donor Derived Germinal Center‐Like Organoids (GCLOs) for Studying Immune Response to Vaccination

Advanced Science, Volume 13, Issue 53, 24 September 2026.
We bioengineered a new approach methodology of generating Germinal Center Organoids that self‐organize from human blood‐derived immune cells. These immune organoids reproduce key features of humoral immunity, IgG production, and plasmablast emergence.
Bhumi Suthar, Carlos Gomez, Giancarlo Asencio, Suresh Pallikkuth, Ashutosh Agarwal   +4 more
wiley   +1 more source

Baseline cerebrospinal fluid complement balance is associated with longitudinal memory decline in relation to plasma p‑tau181 levels in mild cognitive impairment

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION The role of complement in Alzheimer's disease (AD) remains unclear, particularly regarding tau pathology and memory decline. METHODS In 123 mild cognitive impairment (MCI) participants from Alzheimer's Disease Neuroimaging Initiative (ADNI), linear mixed‑effects models and Johnson–Neyman analysis examined associations of baseline ...
Zhinan Ye, Qihan Zhang, Bo Zhang, Bingxin Teng, Shiyue Wang, Jiaxuan Chen, Bohao Li, Hongjie Jin, Zhexin Zheng, Zhuoyu Yang, Xuanang Hu, Xinyan Zhao, Suwen Huang, Yiyun Weng, Dehao Yang   +14 more
wiley   +1 more source

Ultrasmall Fe‐curcumin immunomodulators reinvigorate CAR‐T cells to potentiate solid tumor immunotherapy by mitigating cell exhaustion and senescence

BMEMat, Volume 4, Issue 3, September 2026.
This work discovered a novel research that ultrasmall Fe‐curcumin immunomodulators could reinvigorate CAR‐T cells to potentiate solid tumor immunotherapy by mitigating cell exhaustion and senescence. Abstract CAR‐T cell immunotherapy has achieved exciting success in hematologic malignancies, but the therapeutic efficacy is relatively limited in solid ...
Jiazhi Duan, Yuchan Xue, Miao Zhang, Zihao Zhang, Shiyu Peng, Minghao Sui, Han Ding, Yingying Nie, Yuemin Feng, Le Wang, Tianru Zhang, Mingchuan Yu, He Xia, Hong Liu, Qiang Zhu, Songbo Zhao   +15 more
wiley   +1 more source

The FINE Index: A Frailty‐ and Immunonutrition‐Based Nomogram for Survival in Geriatric Breast Cancer: A Retrospective Study

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Background Elderly breast cancer patients generally have a poorer prognosis. This study developed and validated the FINE Index, a nomogram integrating frailty, immunonutritional, and tumor indicators to predict overall survival (OS) in elderly patients undergoing surgery.
Xiwen Yang, Jiang Zhu
wiley   +1 more source

Impact of Immunosenescence on Vaccine Immune Responses and Countermeasures

The biological progression of aging encompasses complex physiological processes. As individuals grow older, their physiological functions gradually decline, including compromised immune responses, leading to immunosenescence.
Chengwei Shao, Fengcai Zhu, Jingxin Li, Li Chen   +3 more
core   +1 more source