Results 161 to 170 of about 20,223 (261)

The Evolving Landscape of Clinical Aging Clocks: From Epigenetic to Multi‐Omics Integration

Aging Cell, Volume 25, Issue 6, June 2026.
Multi‐omics aging clocks capture biological heterogeneity beyond single‐omics models, improving risk stratification. Key challenges include unknown biological meaning, timescale mismatches, and validation gaps. Future clocks must distinguish pathological damage from adaptive remodeling—damage accumulation is the most actionable target for anti‐aging ...
Liying Liu, Yuanyuan Lai, Chunhui Tian, Yufei Huang, Jianheng Hao, Yuemeng Zhao, Dan Chen, Tianyu Wu, Daqian Zhou, Xiaoyan Zheng, Han Yang, Zheng Yu, Nihong Li, Jie Yang   +13 more
wiley   +1 more source

Impact of Immunosenescence on Vaccine Immune Responses and Countermeasures

The biological progression of aging encompasses complex physiological processes. As individuals grow older, their physiological functions gradually decline, including compromised immune responses, leading to immunosenescence.
Chengwei Shao, Fengcai Zhu, Jingxin Li, Li Chen   +3 more
core   +1 more source

Immunosenescence in Idiopathic Pulmonary Fibrosis. [PDF]

J Inflamm Res
Xiao S, Li Z, Zhang H, Cai W, Yu S, Song X.   +5 more
europepmc   +1 more source

Rapidly Progressive Cutaneous Nodules in an Elderly Woman

JEADV Clinical Practice, Volume 5, Issue 2, Page 737-741, June 2026.
Valeria Olvera‐Rodriguez, Gerardo González‐Martínez, Marion Carolina Alemán‐Jiménez, Minerva Gómez‐Flores, Jorge Ocampo‐Candiani, Lucía T. Fernández   +5 more
wiley   +1 more source

Opposing Association of Lung Neutrophils and PD‐L1+ Monocytes in Age‐Related Severity of SARS‐CoV‐2 Infection

Aging Cell, Volume 25, Issue 6, June 2026.
Aging skews pulmonary myeloid responses during acute SARS‐CoV‐2 infection toward severe disease. Disease progression is characterized by excessive lung neutrophil accumulation together with impaired activation of classical monocytes, including a defect in PD‐L1 upregulation.
Serban Morosan, Clémence Granier, Noëlline Guillou, Selma Bennacer, Eléonore Weber‐Delacroix, Julianne Peronnet, François Lanthiez, Sandrine Barthelemy, Christelle Enond, Jean‐Luc Diehl, Elena Paillaud, Carine El‐Sissy, Anne‐Geneviève Marcelin, Vincent Calvez, Stéphane Marot, Amélie Guihot, Christophe Parizot, Karim Dorgham, Guy Gorochov, Christophe Combadière, Alexandre Boissonnas   +20 more
wiley   +1 more source

Bridging aging and colorectal cancer: synergistic roles of inflammaging and immunosenescence. [PDF]

Front Immunol
Zaongo SD, Yang Q, Han M, Xi T, Luo Z, Wang X, Yang J, Ouyang J.   +7 more
europepmc   +1 more source

Multifunctional Role of Mitochondrial Fatty Acid Oxidation in Cancer Immunotherapy and Aging

Cancer Science, Volume 117, Issue 6, Page 1554-1565, June 2026.
Recent studies have highlighted the complex interplay between tumor immunity, aging, and inflammation. Mitochondrial FAO is a major hub of this physiological interplay. ABSTRACT Recent studies have demonstrated the intricate relationship between tumor immunity, aging, and inflammation.
Koji Kitaoka, Shuhei Hirose, Yu Wang, Tomonori Yaguchi, Kenji Chamoto   +4 more
wiley   +1 more source

Immunosenescence and Inflammaging as Drivers of Neurodegeneration: Cellular Mechanisms, Neuroimmune Crosstalk, and Therapeutic Implications. [PDF]

Cells
Bertoni G, Ristori S, Monti D.
europepmc   +1 more source

Outcomes Following Alemtuzumab Induction in Deceased Donor Kidney Transplantation According to Recipient Age Categories: A Single Center Report

Clinical Transplantation, Volume 40, Issue 6, June 2026.
ABSTRACT Introduction The effects of induction therapy with the anti‐CD52 monoclonal antibody alemtuzumab on age‐specific outcomes following kidney transplantation (KT) remain inadequately studied. This study aimed to analyze the comparative safety and efficacy of single‐dose alemtuzumab induction in deceased donor (DD) KT recipients according to ...
Alex Ng, David I. Harriman, Alan C. Farney, Giuseppe Orlando, Colleen Jay, Amber Reeves‐Daniel, Robert J. Stratta   +6 more
wiley   +1 more source

Senescence of T cells and organ aging. [PDF]

Inflamm Regen
Ohyagi M, Ito M, Yoshimura A.
europepmc   +1 more source