Results 171 to 180 of about 20,223 (261)

CYP2E1 and CYP2D6 in Anti‐Tuberculosis Drug‐Induced Liver Injury: Mechanisms, Epigenetic Regulation, and Translational Implications

Clinical and Translational Science, Volume 19, Issue 6, June 2026.
ABSTRACT Tuberculosis (TB) continues to be a significant global health issue, with anti‐tuberculosis drug‐induced liver injury (ATDILI) representing the most frequent and severe adverse event associated with first‐line therapy. Despite extensive investigation, the mechanistic basis of ATDILI remains incompletely understood.
Pathida Prakongsup, Wanvisa Udomsinprasert   +1 more
wiley   +1 more source

Correction: Immunosenescence and metabolic reprogramming in MASLD: an age-dependent immunometabolic vicious cycle and therapeutic opportunities. [PDF]

Front Cell Dev Biol
Xu Y, Li Q, Jiao X.
europepmc   +1 more source

Incidence and Characteristics of HBV Reactivation‐Related Events Following HBsAg Seroclearance: Long‐Term Follow‐up of a Population‐Based Cohort in Japan

Hepatology Research, Volume 56, Issue 6, Page 944-955, June 2026.
In a population‐based cohort in Japan, HBV reactivation‐related events were observed after HBsAg seroclearance, including one virologically confirmed hepatic flare occurring spontaneously without chemotherapy or immunosuppression. These findings indicate that HBsAg seroclearance does not always represent complete viral eradication, supporting the need ...
Kazumi Yamasaki, Satoshi Shirahama, Takahiro Yasaka, Shota Yamaguchi, Masashi Mizokami, Junko Tanaka, Hiroaki Okamoto, Hiroshi Yatsuhashi   +7 more
wiley   +1 more source

Efficacy and Safety of Anti‐IL‐4Rα Stapokibart in Elderly Patients With Moderate‐To‐Severe Atopic Dermatitis

International Journal of Dermatology, Volume 65, Issue 6, Page 1185-1194, June 2026.
ABSTRACT Background Elderly patients with moderate‐to‐severe atopic dermatitis (AD) often exhibit more heterogeneous inflammatory profiles compared with younger adults. To evaluate the efficacy and safety of stapokibart, an anti‐interleukin‐4 receptor α subunit (IL‐4Rα) monoclonal antibody, in different age subgroups.
Yan Zhao, Litao Zhang, Liming Wu, Bin Yang, Jinyan Wang, Yumei Li, Qingchun Diao, Jingyi Li, Qing Sun, Xiaohong Zhu, Xiaoyong Man, Lihua Wang, Yanyan Feng, Tao Cai, Huiming Zeng, Linfeng Li, Jianyun Lu, Hong Ren, Fuqiu Li, Qianjin Lu, Xiaohua Tao, Rong Xiao, Chao Ji, Jing Sun, Yanping Qiu, Bo Chen, Jianzhong Zhang   +26 more
wiley   +1 more source

Immunosenescence in Human Disease: Mechanistic Insights and Therapeutic Opportunities. [PDF]

Biomol Ther (Seoul)
Kim YI, Oh SH, Lim TK, Lee H, Lee S, Chang SY.   +5 more
europepmc   +1 more source

Resilient Biophysical Phenotype of Memory CD4 + T Cells in Long‐Lived Mice

Immunology, Volume 178, Issue 2, Page 363-374, June 2026.
Aging is associated with increased stiffness and reduced migratory capacity of memory CD4+ T cells; however, these biophysical declines do not persist in exceptionally long‐lived mice. Instead, long‐lived individuals preserve T cell mechanics, migration and intracellular architecture, supporting mechanical resilience as a hallmark of successful immune ...
Aldo Abarca‐Ortega, Blanca González‐Bermúdez, Judith Félix‐Escalera, Mónica González‐Sánchez, Enzo Brito, Mónica De la Fuente, Gustavo R. Plaza   +6 more
wiley   +1 more source

Immunosenescence in Older Patients with Psoriasis: Mechanistic Insights and Opportunities for Biologic Therapy. [PDF]

Psoriasis (Auckl)
Wang W, Zha S, Sun L, Zhou D.
europepmc   +1 more source

Integration of Transcriptomics With Interpretable Artificial Intelligence for Identifying Molecular Signatures of Physiological Stress in Sleep Deprivation

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Sleep deprivation induces systemic physiological stress accompanied by transcriptomic remodelling and immune dysregulation, yet objective molecular indicators for its assessment remain insufficient. This study integrated blood transcriptomic analysis with an interpretable machine learning framework to identify and validate candidate molecular ...
Kun Wang, Qiang Zong, Chengcheng Wang, Peng Wang, Zhenhao Shuai, Min Wu, Yuming Peng, Junying Zhou, Jianwei Shuai, Fangfu Ye, Aimin Wu, Yanyan Zheng   +11 more
wiley   +1 more source

Conquering aging-related immunosenescence and tumor immune escape. [PDF]

Front Immunol
Zhang S, Yang B, Xu M, Bing Y, Zhang J, Wang Y, Zheng C, Zhang G, Zhang L.   +8 more
europepmc   +1 more source

The NF‐κB Signalling Pathway: Mechanisms, Consequences and Therapeutic Targets

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Nuclear Factor‐kappa B (NF‐κB) is a master transcriptional regulator orchestrating critical cellular processes, predominantly immunity and inflammation. However, its aberrant constitutive activation has emerged as a unifying pathogenetic hallmark across diverse malignancies, autoimmune disorders, and chronic inflammatory diseases.
Bherouz Pourdad, Arash Pourdad
wiley   +1 more source