Results 1 to 10 of about 24,957 (279)
The controversial role of senescence-associated secretory phenotype (SASP) in cancer therapy
Molecular CancerCellular senescence, characterized by partially irreversible cell cycle arrest, has a dual role in cancer progression via the senescence-associated secretory phenotype (SASP).
Qiang Tong
exaly +3 more sources
The double-edged sword of SASP in breast cancer: from tumor suppression to progression and therapy resistance. [PDF]
Front OncolThe senescence-associated secretory phenotype (SASP) represents a complex and dynamic collection of bioactive factors secreted by senescent cells, which exerts dual regulatory effects on breast cancer (BC) progression. When SASP is transiently expressed,
Gao X, Zhang Y, Sun Y, Xu T.
europepmc +3 more sources
CellsCellular senescence regulates aging, tissue maintenance, and disease progression through the Senescence-Associated Secretory Phenotype (SASP), a secretory profile of cytokines, chemokines, growth factors, and matrix-remodeling enzymes.
Hassabelrasoul Abdelgadir +2 more
exaly +4 more sources
Targeting senescence-associated secretory phenotype macrophage: apigenin inhibits DOT1L-dependent H3K79me2 at <i>IL1A</i> to fight SASP in senescent macrophages. [PDF]
Front Mol BiosciIntroductionApigenin (API) has been utilized in the treatment of atherosclerosis. Senescent macrophages exhibit a senescence-associated secretory phenotype (SASP), which plays a critical role in the progression of atherosclerosis.
Ni G, Ma N, Xu J.
europepmc +3 more sources
Cationic local composition fluctuations in rapidly cooled nuclear fuel melts
Nuclear Materials and Energy, 2022 During a severe accident in a nuclear reactor, as it occurred in Fukushima Daiichi BWRs in 2011, the so-called “corium” resulting from the thermal fusion of nuclear fuel and interaction with the zircaloy cladding at high temperature (T > 2800 K) can be ...
Mohamed Jizzini +4 more
doaj +1 more source
The Histone Code of Senescence
Cells, 2020 Senescence is the end point of a complex cellular response that proceeds through a set of highly regulated steps. Initially, the permanent cell-cycle arrest that characterizes senescence is a pro-survival response to irreparable DNA damage.
Harikrishnareddy Paluvai +2 more
doaj +1 more source
Phenomenology and Mind, 2017 There is a prevalent tension within recent cognitive scientific accounts of human selfhood in that either bodily processes or social processes are explanatorily favored at the expense of the other.
Joe Higgins
doaj +1 more source
Erciyes Medical Journal, 2019 Objective: In the present study we aim to evaluate whether some of the proteins previously identified in the secretome of senescent bone marrow (BM)- and adipose (A)-mesenchymal stromal cells (MSCs) could be involved in regulation of senescence phenomena.
Tiziana Squillaro +7 more
doaj +1 more source
Cells, 2020 Immunosenescence in monocytes has been shown to be associated with several biochemical and functional changes, including development of senescence-associated secretory phenotype (SASP), which may be inhibited by klotho protein.
Jennifer Mytych +6 more
doaj +1 more source
Senescence-associated secretory phenotype and its impact on oral immune homeostasis
Frontiers in Immunology, 2022 The senescence-associated secretory phenotype (SASP), which accumulates over the course of normal aging and in age-related diseases, is a crucial driver of chronic inflammation and aging phenotypes. It is also responsible for the pathogenesis of multiple
Ziqi Yue +12 more
doaj +1 more source