Results 1 to 10 of about 26,150 (274)

SASP – Physiotherapy beyond 100 years of rehabilitation

South African Journal of Physiotherapy
No abstract ...
Witness Mudzi
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The role of senescence-associated secretory phenotype (SASP) in cellular senescene

Acta Biochimica Indonesiana, 2021
Cellular senescence is one of the defense mechanisms of cells against oncogenic signals by permanently stopping the proliferation of the cell. Senescence cells show a similar characteristic, one of them is senescence-associated secretory phenotype (SASP).
Filda Vionita Irene de Lime, Novi Silvia Hardiany   +1 more
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Role of Clusterin/NF-κB in the secretion of senescence-associated secretory phenotype in Cr(VI)-induced premature senescent L-02 hepatocytes

Ecotoxicology and Environmental Safety, 2021
Hexavalent chromium [Cr(VI)] and its compounds have caused serious environmental pollution and health damage. Senescent cells can actively change the surrounding environment by secreting some factors, which are called senescence associated secretory ...
Yuehui Liang, Ningjuan Liang, Yu Ma, Sixuan Tang, Shuzi Ye, Fang Xiao   +5 more
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SMP30: a promising cancer biomarker with therapeutic potential

Open Medicine
SMP30 is a calcium binding protein closely related to cellular senescence. Low expression of SMP30 is significantly associated with malignant progression and poor prognosis in tumors, suggesting it values as a potential diagnostic biomarker and ...
Chen Pei, Zhang Yu-ling, Guo Ying
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Targeting Cellular Senescence in Prostate Cancer: Molecular Landscape and Therapeutic Avenues

Annals of Urologic Oncology
Prostate cancer is one of the major causes of cancer morbidity and mortality in men, especially at advanced stages where treatment fails. Despite the fact that the existing treatment options, such as androgen deprivation therapy, chemotherapy ...
Haneen Hossam, Bandar Alattaibi
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Extracellular vesicles circulating in young organisms promote healthy longevity

Journal of Extracellular Vesicles, 2019
Parabiosis experiments in mice demonstrated that a young environment could partially rejuvenate multiple tissues of old organisms. However, the circulating mediators responsible of such effect have been elusive so far.
Francesco Prattichizzo, Angelica Giuliani, Jacopo Sabbatinelli, Emanuela Mensà, Valeria De Nigris, Lucia La Sala, Paola de Candia, Fabiola Olivieri, Antonio Ceriello   +8 more
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N-Acetyltransferase 10 Promotes Micronuclei Formation to Activate the Senescence-Associated Secretory Phenotype Machinery in Colorectal Cancer Cells

Translational Oncology, 2020
The formation of micronuclei (MN) is prevalent in human cancer cells and its role in activating the senescence-associated secretory phenotype (SASP) machinery has been identified recently.
Yanan Cao, Mengfei Yao, Yaqian Wu, Ningning Ma, Haijing Liu, Bo Zhang   +5 more
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Senescent cells: New target for an old treatment?

Molecular & Cellular Oncology, 2017
Many genotoxic chemotherapies have debilitating side effects and induce cellular senescence in normal tissues. Senescent cells acquire a pro-inflammatory phenotype which contributes to local and systemic inflammation.
Marco Demaria
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SENOLYTICS AND SENOMORPHICS: A NEW CLASS OF DRUGS FOR ANTI-AGING THERAPY

Central Asian Journal of Medical Hypotheses and Ethics
Aging is a complex biological process characterized by the accumulation of senescent cells that adopt a senescence-associated secretory phenotype (SASP), releasing proinflammatory mediators that drive tissue dysfunction and the onset of age-related ...
Timur Saliev, Prim B. Singh
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Research Progress on the Regulation Mechanism of Senescence-associated Secretory Phenotype in Osteoporosis [PDF]

Zhongguo quanke yixue
Senescence-associated secretory phenotype (SASP) is an important feature of cellular senescence and plays an important role in regulating the disease microenvironment.
YANG Chaofu, TAN Guoqing, XU Zhanwang
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