Results 1 to 10 of about 19,296 (119)
The controversial role of senescence-associated secretory phenotype (SASP) in cancer therapy
Molecular CancerCellular senescence, characterized by partially irreversible cell cycle arrest, has a dual role in cancer progression via the senescence-associated secretory phenotype (SASP).
Qiang Tong, Tong Qiang
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Cationic local composition fluctuations in rapidly cooled nuclear fuel melts
Nuclear Materials and Energy, 2022 During a severe accident in a nuclear reactor, as it occurred in Fukushima Daiichi BWRs in 2011, the so-called “corium” resulting from the thermal fusion of nuclear fuel and interaction with the zircaloy cladding at high temperature (T > 2800 K) can be ...
Mohamed Jizzini +4 more
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The Histone Code of Senescence
Cells, 2020 Senescence is the end point of a complex cellular response that proceeds through a set of highly regulated steps. Initially, the permanent cell-cycle arrest that characterizes senescence is a pro-survival response to irreparable DNA damage.
Harikrishnareddy Paluvai +2 more
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Phenomenology and Mind, 2017 There is a prevalent tension within recent cognitive scientific accounts of human selfhood in that either bodily processes or social processes are explanatorily favored at the expense of the other.
Joe Higgins
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Erciyes Medical Journal, 2019 Objective: In the present study we aim to evaluate whether some of the proteins previously identified in the secretome of senescent bone marrow (BM)- and adipose (A)-mesenchymal stromal cells (MSCs) could be involved in regulation of senescence phenomena.
Tiziana Squillaro +7 more
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Cells, 2020 Immunosenescence in monocytes has been shown to be associated with several biochemical and functional changes, including development of senescence-associated secretory phenotype (SASP), which may be inhibited by klotho protein.
Jennifer Mytych +6 more
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Probiotic bacteria as modulators of cellular senescence: emerging concepts and opportunities
Gut Microbes, 2020 Probiotic bacteria are increasingly gaining importance in human nutrition owing to their multifaceted health beneficial effects. Studies have also shown that probiotic supplementation is useful in mitigating age-associated oxi-inflammatory stress ...
Rohit Sharma, Yogendra Padwad
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Senescence-associated secretory phenotype and its impact on oral immune homeostasis
Frontiers in Immunology, 2022 The senescence-associated secretory phenotype (SASP), which accumulates over the course of normal aging and in age-related diseases, is a crucial driver of chronic inflammation and aging phenotypes. It is also responsible for the pathogenesis of multiple
Ziqi Yue +12 more
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Dual role of PRMT1-dependent arginine methylation in cellular responses to genotoxic stress
Molecular & Cellular Oncology, 2020 We have recently shown that arginine methylation by protein arginine N-methyltransferase 1 (PRMT1) controls the response to cisplatin in ovarian cancer cells.
Roberto Giambruno, Tiziana Bonaldi
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Sensitive detection and monitoring of senescence-associated secretory phenotype by SASP-RAP assay. [PDF]
PLoS ONE, 2012 Senescence-associated secretory phenotype (SASP) is characterized by abundant secretion of various proteins in senescent cells and implicated in tumor progression and inflammatory responses.
Liubao Gu, Masanori Kitamura
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