Cancer cell cannibalism and the SASP: Ripples in the murky waters of tumor dormancy
Molecular & Cellular Oncology, 2017 Relapse in cancer patients following an apparent cure and a prolonged latency period, known as tumor dormancy, remains an unrelenting clinical crisis.
Thomas J. Bartosh
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Dual role of PRMT1-dependent arginine methylation in cellular responses to genotoxic stress
Molecular & Cellular Oncology, 2020 We have recently shown that arginine methylation by protein arginine N-methyltransferase 1 (PRMT1) controls the response to cisplatin in ovarian cancer cells.
Roberto Giambruno, Tiziana Bonaldi
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Loss of MECP2 Leads to Activation of P53 and Neuronal Senescence. [PDF]
, 2018 To determine the role for mutations of MECP2 in Rett syndrome, we generated isogenic lines of human induced pluripotent stem cells, neural progenitor cells, and neurons from patient fibroblasts with and without MECP2 expression in an attempt to ...
Allen, Denise +17 more
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A proteomic atlas of senescence-associated secretomes for aging biomarker development. [PDF]
, 2020 The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of and promising therapeutic target for multiple age-related conditions, ranging from neurodegeneration to cancer.
Basisty, Nathan +11 more
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Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4+CD25+FoxP3+ regulatory T cells activation [PDF]
, 2020 Rationale: Loss of histone macroH2A1 induces appearance of cancer stem cells (CSCs)-like cells in hepatocellular carcinoma (HCC). How CSCs interact with the tumor microenvironment and the adaptive immune system is unclear. Methods: We screened aggressive
Drovakova A. +11 more
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Role of cellular senescence and NOX4-mediated oxidative stress in systemic sclerosis pathogenesis. [PDF]
, 2015 Systemic sclerosis (SSc) is a systemic autoimmune disease characterized by progressive fibrosis of skin and numerous internal organs and a severe fibroproliferative vasculopathy resulting frequently in severe disability and high mortality.
A Diazdeleon +130 more
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Molecular & Cellular Oncology, 2020 The breast tumors that are most difficult to eradicate with chemotherapy have wild-type TP53 and preferentially enter senescence after treatment. One factor contributing to the persistence of senescent cells in residual disease: acquisition of a novel ...
Crystal A. Tonnessen-Murray +1 more
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The light and shadow of senescence and inflammation in cardiovascular pathology and regenerative medicine [PDF]
, 2017 Recent epidemiologic studies evidence a dramatic increase of cardiovascular diseases, especially associated with the aging of the world population. During aging, the progressive impairment of the cardiovascular functions results from the compromised ...
Cavarretta, Elena +9 more
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The Dynamic Process and Its Dual Effects on Tumors of Therapy-Induced Senescence
Cancer Management and Research, 2020 Chenxi Liao,1,* Yin Xiao,2,* Lingbo Liu1 1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People’s Republic of China; 2Cancer Center, Union Hospital, Tongji Medical ...
Liao C, Xiao Y, Liu L
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Senescence drives non-cell autonomous tumorigenesis in the pituitary gland
Molecular & Cellular Oncology, 2018 Novel detrimental functions of senescent cells have been recently uncovered in the context of cancer development and progression, which they mainly exert through the secretion of several pro-tumorigenic factors.
Jose Mario Gonzalez-Meljem +1 more
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