Results 31 to 40 of about 26,150 (274)
SASP-related genes upregulated in ALGS livers versus non-cholestatic controls.
, 2023 SASP-related genes upregulated in ALGS livers versus non-cholestatic controls.
Mustapha Najimi (143882) +6 more
core +1 more source
Epiregulation of the SASP makes good neighbors
Nature Aging, 2021 The tumor microenvironment (TME) impacts different phases of tumor progression and therapy resistance. Zhang et al. show that senescent stromal cells activate an epigenetic program that controls the senescence-associated secretory phenotype and can be targeted to boost responses to chemotherapy.
Desbats, Maria Andrea +2 more
openaire +3 more sources
Dissecting cellular senescence and SASP in Drosophila [PDF]
Inflammation and Regeneration, 2016 Cellular senescence can act as both tumor suppressor and tumor promoter depending on the cellular contexts. On one hand, premature senescence has been considered as an innate host defense mechanism against carcinogenesis in mammals. In response to various stresses including oxidative stress, DNA damage, and oncogenic stress, suffered cells undergo ...
Ito, Takao, Igaki, Tatsushi
openaire +2 more sources
The role of cellular senescence and SASP in tumour microenvironment [PDF]
The FEBS Journal, 2022 Cellular senescence refers to a state of irreversible cell cycle arrest that can be induced by various cellular stresses and is known to play a pivotal role in tumour suppression. While senescence‐associated growth arrest can inhibit the proliferation of cancer‐prone cells, the altered secretory profile of senescent cells, termed the senescence ...
Masaki Takasugi +3 more
openaire +2 more sources
The Histone Code of Senescence
Cells, 2020 Senescence is the end point of a complex cellular response that proceeds through a set of highly regulated steps. Initially, the permanent cell-cycle arrest that characterizes senescence is a pro-survival response to irreparable DNA damage.
Harikrishnareddy Paluvai +2 more
doaj +1 more source
Phenomenology and Mind, 2017 There is a prevalent tension within recent cognitive scientific accounts of human selfhood in that either bodily processes or social processes are explanatorily favored at the expense of the other.
Joe Higgins
doaj +1 more source
Gene expression of senescence and SASP markers in ALGS livers.
, 2023 (A) Gene expression of p21 and p16 increases in ALGS livers. (B) Gene expression of SASP markers TGF-β1, IL-6 and IL-8 is unchanged in ALGS livers. ALGS: Alagille syndrome; SASP: senescence-associated secretory phenotype. Data is presented as mean ± SD; *
Mustapha Najimi (143882) +6 more
core +1 more source
Erciyes Medical Journal, 2019 Objective: In the present study we aim to evaluate whether some of the proteins previously identified in the secretome of senescent bone marrow (BM)- and adipose (A)-mesenchymal stromal cells (MSCs) could be involved in regulation of senescence phenomena.
Tiziana Squillaro +7 more
doaj +1 more source
GH Is a Component of SASP in Aging Tissue [PDF]
Journal of the Endocrine Society, 2021 Abstract Deficient GH signaling results in lifespan extension in murine and human models, while patients with uncontrolled acromegaly and transgenic mice overexpressing GH have a shorter lifespan. Colon polyp development increases with age, and also with GH excess in acromegaly.
Chesnokova, Vera M +4 more
openaire +1 more source
Cells, 2020 Immunosenescence in monocytes has been shown to be associated with several biochemical and functional changes, including development of senescence-associated secretory phenotype (SASP), which may be inhibited by klotho protein.
Jennifer Mytych +6 more
doaj +1 more source