Results 31 to 40 of about 22,235 (292)

Gene expression of senescence and SASP markers in ALGS livers.

, 2023
(A) Gene expression of p21 and p16 increases in ALGS livers. (B) Gene expression of SASP markers TGF-β1, IL-6 and IL-8 is unchanged in ALGS livers. ALGS: Alagille syndrome; SASP: senescence-associated secretory phenotype. Data is presented as mean ± SD; *
Mustapha Najimi (143882), Catherine de Magnée (11086299), Roberto Tambucci (11086296), Jonathan Evraerts (511703), Giulia Jannone (8560338), Joachim Ravau (15361100), Etienne Marc Sokal (15361103)   +6 more
core   +1 more source

SASP Atlas: A comprehensive resource for SASPs.

, 2020
SASP Atlas (www.SASPAtlas.com) is a curated and freely available database of the secretomes of senescent cells, including both the soluble and exosome SASP, that can be used to identify SASP components or biomarker candidates for senescence burden, aging,
Luigi Ferrucci (150038), Samah Shah (8313159), Vagisha Sharma (708257), Birgit Schilling (31153), Therese Payne (8313153), Anja Holtz (174441), Abhijit Kale (117142), Ok Hee Jeon (8313147), Chirag Rao (8313156), Nathan Basisty (343839), Chisaka Kuehnemann (8313150), Judith Campisi (17061)   +11 more
core   +1 more source

Cancer cell cannibalism and the SASP: Ripples in the murky waters of tumor dormancy

Molecular & Cellular Oncology, 2017
Relapse in cancer patients following an apparent cure and a prolonged latency period, known as tumor dormancy, remains an unrelenting clinical crisis.
Thomas J. Bartosh
doaj   +1 more source

Apoptotic stress causes mtDNA release during senescence and drives the SASP [PDF]

, 2023
\ua9 2023, The Author(s). Senescent cells drive age-related tissue dysfunction partially through the induction of a chronic senescence-associated secretory phenotype (SASP)1.
Riley JS, Salmonowicz H, Cloix C, Hall-Younger E, Sales Gomez L, Tait SWG, Saul D, Huang H, Reed R, Passos JF, Martini H, Machado Espindola-Netto J, Eppard M, Pirius N, Greaves LC, LeBrasseur NK, Porritt RA, Dou Z, Szczepanowska K, Vizioli MG, Kelly G, Kaufmann SH, Zacharioudakis E, Farr JN, Shadel GS, Masuda CA, Jurk D, Adams PD, Huang TY, Gavathiotis E, Lagnado AB, Mann DA, Sainz AG, Victorelli S, Lei X, Khosla S, Korolchuk VI, Chapman J, Dai H   +38 more
core   +3 more sources

Engulfment and cannibalism drive persistence of chemotherapy-treated tumor cells: can they be targeted?

Molecular & Cellular Oncology, 2020
The breast tumors that are most difficult to eradicate with chemotherapy have wild-type TP53 and preferentially enter senescence after treatment. One factor contributing to the persistence of senescent cells in residual disease: acquisition of a novel ...
Crystal A. Tonnessen-Murray, James G. Jackson   +1 more
doaj   +1 more source

Secondary amine selective Petasis (SASP) bioconjugation

Chemical Science, 2020
Secondary amine selective Petasis (SASP) bioconjugation for the selective labeling of peptides and proteins with N-terminal secondary amines.
Yonnette E. Sim, Ogonna Nwajiobi, Sriram Mahesh, Ryan D. Cohen, Mikhail Y. Reibarkh, Monika Raj   +5 more
openaire   +3 more sources

Progression of irradiated mesenchymal stromal cells from early to late senescence: Changes in SASP composition and anti-tumour properties

, 2023
: Genotoxic injuries converge on senescence-executive program that promotes production of a senescence-specific secretome (SASP). The study of SASP is particularly intriguing, since through it a senescence process, triggered in a few cells, can spread to
Squillaro, Tiziana, Servet Özcan, Alessio, Nicola, Gianfranco Peluso, Peluso, Gianfranco, Galderisi, Umberto, Aprile, Domenico, Tiziana Squillaro, Şerife Ayaz‐Güner, Umberto Galderisi, Giovanni Di Bernardo, Acar, Mustafa Burak, Domenico Aprile, Ayaz‐Güner, Şerife, Ayaz-Güner, Şerife, Di Bernardo, Giovanni, Özcan, Servet, Mustafa Burak Acar, Nicola Alessio   +18 more
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Senescence drives non-cell autonomous tumorigenesis in the pituitary gland

Molecular & Cellular Oncology, 2018
Novel detrimental functions of senescent cells have been recently uncovered in the context of cancer development and progression, which they mainly exert through the secretion of several pro-tumorigenic factors.
Jose Mario Gonzalez-Meljem, Juan Pedro Martinez-Barbera   +1 more
doaj   +1 more source

The Dynamic Process and Its Dual Effects on Tumors of Therapy-Induced Senescence

Cancer Management and Research, 2020
Chenxi Liao,1,* Yin Xiao,2,* Lingbo Liu1 1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People’s Republic of China; 2Cancer Center, Union Hospital, Tongji Medical ...
Liao C, Xiao Y, Liu L
doaj  

Ex-SASP-erating cancer [PDF]

Science-Business eXchange, 2013
German researchers have identified a hypermetabolic phenotype in senescent tumor cells that exerts tumorigenic effects on other cells in the tumor microenvironment. Although small molecule inhibitors of the phenotype improved survival in a mouse model of lymphoma, future studies will need to determine whether the phenotype occurs in primary tumors.
openaire   +1 more source