Results 31 to 40 of about 30,415 (217)

Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence [PDF]

, 2019
The activation of cellular senescence throughout the lifespan promotes tumor suppression, whereas the persistence of senescent cells contributes to aspects of aging.
Diekman, Brian O., Gudkov, Andrei V., Hall, Brandon M., Krishnamurthy, Janakiraman, Liu, Jie-Yu, Parker, Joel S., Sessions, Garrett A., Sharpless, Norman E., Sorrentino, Jessica A., Souroullas, George P.   +9 more
core   +3 more sources

The role of senescence-associated secretory phenotype (SASP) in cellular senescene

Acta Biochimica Indonesiana, 2021
Cellular senescence is one of the defense mechanisms of cells against oncogenic signals by permanently stopping the proliferation of the cell. Senescence cells show a similar characteristic, one of them is senescence-associated secretory phenotype (SASP).
Filda Vionita Irene de Lime, Novi Silvia Hardiany   +1 more
doaj   +1 more source

The Rbm38-p63 feedback loop is critical for tumor suppression and longevity. [PDF]

, 2018
The RNA-binding protein Rbm38 is a target of p63 tumor suppressor and can in-turn repress p63 expression via mRNA stability. Thus, Rbm38 and p63 form a negative feedback loop.
Chen, Mingyi, Chen, Xinbin, Flores, Elsa, Jiang, Yuqian, Xu, Enshun, Zhang, Jin   +5 more
core   +1 more source

Role of Clusterin/NF-κB in the secretion of senescence-associated secretory phenotype in Cr(VI)-induced premature senescent L-02 hepatocytes

Ecotoxicology and Environmental Safety, 2021
Hexavalent chromium [Cr(VI)] and its compounds have caused serious environmental pollution and health damage. Senescent cells can actively change the surrounding environment by secreting some factors, which are called senescence associated secretory ...
Yuehui Liang, Ningjuan Liang, Yu Ma, Sixuan Tang, Shuzi Ye, Fang Xiao   +5 more
doaj   +1 more source

The role of inflammation in age-related disease. [PDF]

, 2013
The National Institutes of Health (NIH) Geroscience Interest Group (GSIG) sponsored workshop, The Role of Inflammation inAge-Related Disease, was held September 6th-7th, 2012 in Bethesda, MD.
Augustine, Alison Deckhut, Campisi, Judith, Howcroft, T Kevin, Kohanski, Ron, Louis, Germaine Buck, McElhaney, Janet E, Sierra, Felipe, Smith, Martyn T, Wise, Bradley, Wyss-Coray, Tony   +9 more
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Arsenite exposure induces premature senescence and senescence-associated secretory phenotype (SASP) in human hepatocyte-derived cell line Huh-7

Environmental Health and Preventive Medicine
Background: Chronic arsenite exposure has been known to induce cancer in various organs; however, the underlying mechanisms remain elusive. The characteristic feature of carcinogenesis due to arsenic exposure is that the disease develops after a ...
Kazuyuki Okamura, Miyuki Sato, Takehiro Suzuki, Keiko Nohara   +3 more
doaj   +1 more source

(-)-α-Bisabolol inhibits D-Gal-induced HSF cellular senescence in vitro and prevents skin aging in vivo by reducing SASP [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): To study the anti-aging effect of (-)-α-bisabolol ((-)-α-bis) on the skin and preliminarily clarify its mechanism. Materials and Methods: Human skin fibroblasts (HSF) were induced senescence by D-Galactose.
Meixing He, Panyu Zhou, Hankun Chen, Junhong Zhang, Yating Zhang, Xianhui Zheng, Wei Zhu, Ling Han   +7 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

SASP – Physiotherapy beyond 100 years of rehabilitation

South African Journal of Physiotherapy
No abstract ...
Witness Mudzi
doaj   +1 more source