Results 1 to 10 of about 12,850 (181)

Sulfasalazine prevents lung injury due to intra-abdominal sepsis in rats: possible role of Nrf2 and angiopoietin-2 [PDF]

Brazilian Journal of Medical and Biological Research, 2023
This study aimed to investigate the effect of sulfasalazine in preventing and treating intra-abdominal sepsis-induced acute respiratory distress syndrome (ARDS) in a rat model. Forty male Wistar albino rats were used.
C. Dibekoğlu, Y. Uyanıkgil, O. Erbaş
doaj   +1 more source

The effect of sulfasalazine in pentylenetetrazole-induced seizures in rats

Brazilian Journal of Medical and Biological Research, 2021
We aimed to reveal the anti-convulsant effects sulfasalazine and its mechanism in pentylenetetrazole (PTZ)-induced seizures in rats. Forty-eight male Wistar albino rats (200-250 g) were randomly divided into two groups: 24 for electroencephalography (EEG)
E.S. Bora, R. Karaali, P.Y. Akyol, G. Yurtsever, O. Erbaş   +4 more
doaj   +1 more source

Sulfasalazine-induced renal and hepatic injury in rats and the protective role of taurine [PDF]

BioImpacts, 2016
Introduction: Sulfasalazine is a drug commonly administrated against inflammatory-based disorders. On the other hand, kidney and liver injury are serious adverse events accompanied by sulfasalazine administration.
Reza Heidari, Maryam Rasti, Babak Shirazi Yeganeh, Hossein Niknahad, Arastoo Saeedi, Asma Najibi   +5 more
doaj   +1 more source

Synthesis of Nano Hydroxyapatite: Application in Drug Delivery of Sulfasalazine [PDF]

Journal of Nanostructures, 2015
In this work we synthesized Nano hydroxyapatite (HAp)  by Sol-gel method, Then we functionalized hydroxyapatite nanoparticle by use of  3-Aminopropyl trimethoxysilane (APTMS) , to improve the loading and control release of sulfasalazine drug bonded to ...
D. Moslemi, S. Mortazavi-Derazkola, S. Masoumeh Ghoreishi   +2 more
doaj   +1 more source

How different is the status of depression and anxiety in patients with rheumatoid arthritis receiving methotrexate with sulfasalazine or hydroxychloroquine?

Russian Open Medical Journal, 2023
Background — Depression and anxiety are among the most common clinical manifestations in patients with rheumatoid arthritis (RA). Sulfasalazine and hydroxychloroquine are important medications used to treat these patients.
Mansour Babaei, Mehdi Dorparvar, Behnaz Yousef Ghahari, Behzad Heidari, Hemmat Gholinia, Sussan Moudi   +5 more
doaj   +1 more source

Effect of sulfasalazine on endothelium-dependent vascular response by the activation of Nrf2 signalling pathway

Frontiers in Pharmacology, 2022
Background: Diabetes mellitus leads to endothelial dysfunction and accumulation of oxygen radicals. Sulfasalazine-induced Nrf2 activation reduces oxidative stress in vessels.
Muhammed Ikbal Sonmez, Muhammed Ikbal Sonmez, Muhammed Ikbal Sonmez, Andleeb Shahzadi, Cagla Kose, Cagla Kose, Haktan Sonmez, Sibel Ozyazgan, Ahmet Gokhan Akkan, Ahmet Gokhan Akkan   +9 more
doaj   +1 more source

Sulfasalazine induces mitochondrial dysfunction and renal injury

Renal Failure, 2017
Sulfasalazine is a commonly used drug for the treatment of rheumatoid arthritis and inflammatory bowel disease. There are several cases of renal injury encompass sulfasalazine administration in humans.
Hossein Niknahad, Reza Heidari, Roya Mohammadzadeh, Mohammad Mehdi Ommati, Forouzan Khodaei, Negar Azarpira, Narges Abdoli, Mahdi Zarei, Behnam Asadi, Maryam Rasti, Babak Shirazi Yeganeh, Vahid Taheri, Arastoo Saeedi, Asma Najibi   +13 more
doaj   +1 more source

Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain. [PDF]

, 2015
Overproduction of immunoglobulin light chains leads to systemic amyloidosis, a lethal disease characterized by the formation of amyloid fibrils in patients' tissues. Excess light chains are in equilibrium between dimers and less stable monomers which can
Brumshtein, Boris, Cascio, Duilio, Eisenberg, David S, Esswein, Shannon R, Ly, Alan T, Phillips, Martin L, Salwinski, Lukasz, Sawaya, Michael R   +7 more
core   +1 more source

Interaction of sulfasalazine with outer surface of boron-nitride nanotube as a drug carrier in aqueous solution: insights from quantum mechanics and Monte Carlo simulation

BMC Chemistry, 2023
The improvement of the solubility of sulfasalazine in physiological media was the major aim of this study. Accordingly, BNNT inspected as a notable candidate for the carriage of this drug in aqueous media.
Sepideh Ketabi, Saba Shalmashi, Sara Hallajian   +2 more
doaj   +1 more source

Pharmacological strategies in lung cancer-induced cachexia: effects on muscle proteolysis, autophagy, structure, and weakness [PDF]

, 2014
Muscle wasting and cachexia are important systemic manifestations of highly prevalent conditions including cancer. Inflammation, oxidative stress, autophagy, ubiquitin-proteasome system, nuclear factor (NF)-kB, and mitogen activated protein kinases (MAPK)
Bal, Elisa Dora, Barreiro, Eshter, Chacon Cabrera, Alba, Diament, Miriam, Fermoselle, Clara, Mateu Jimenez, Mercè, Sandri, Marco, Urtreger, Alejandro Jorge   +7 more
core   +1 more source