Safety and pharmacokinetics of sulfasalazine and its metabolite sulfapyridine for treatment of preterm preeclampsia in Australia (SIP): an early phase, unblinded, single-arm, proof of concept clinical trialResearch in context [PDF]
EClinicalMedicineSummary: Background: Preeclampsia is a hypertensive pregnancy disorder marked by systemic inflammation and endothelial dysfunction. Sulfasalazine, an anti-inflammatory agent, may have therapeutic potential in preeclampsia.
Elif Kadife +11 more
doaj +3 more sources
Network Pharmacology Guided Drug Repurposing and Molecular Modeling Identify Sulfasalazine as a Potential OXA-23 β-Lactamase in Carbapenem-Resistant <i>Acinetobacter baumannii</i>. [PDF]
Int J Mol SciSagini HA.
europepmc +2 more sources
Evaluating KRAS-Associated Responses to Sulfasalazine and 5-Fluorouracil in Colorectal Cancer Using Integrated 2D and PEGDA Microwell-Based 3D Tumor Models. [PDF]
Int J Mol SciBandegi M, Biltekin E, Akay YM, Akay M.
europepmc +2 more sources
Phase 1 dose-escalation trial combining sulfasalazine and stereotactic radiosurgery in patients with recurrent glioblastoma. [PDF]
Redox BiolSkeie BS +16 more
europepmc +2 more sources
Phase I trial combining sulfasalazine and gamma knife radiosurgery for recurrent glioblastoma. [PDF]
MethodsXSkeie BS +6 more
europepmc +2 more sources
Translational Modeling of Gut Microbiome-Mediated Drug Metabolism: A Case Example of Sulfasalazine. [PDF]
CPT Pharmacometrics Syst PharmacolCheng L +8 more
europepmc +2 more sources
Sulfasalazine prevents lung injury due to intra-abdominal sepsis in rats: possible role of Nrf2 and angiopoietin-2 [PDF]
Brazilian Journal of Medical and Biological Research, 2023 This study aimed to investigate the effect of sulfasalazine in preventing and treating intra-abdominal sepsis-induced acute respiratory distress syndrome (ARDS) in a rat model. Forty male Wistar albino rats were used.
C. Dibekoğlu, Y. Uyanıkgil, O. Erbaş
doaj +1 more source
Effect of Garlic Oil on Sulfasalazine Induced Injury of Renal Tubules [PDF]
The Egyptian Journal of Histology, 2023 Introduction: Sulfasalazine is a disease modifying anti-rheumatic medication, used in the treatment of idiopathic arthritis. Kidney damage is one of its side effects.Objective: To investigate the protective role of garlic oil against sulfasalazine ...
fouad heikal +4 more
doaj +1 more source
Expression of Concern: Sulfasalazine induces mitochondrial dysfunction and renal injury. [PDF]
Ren Faileuropepmc +2 more sources
Drug-Induced Subacute Cutaneous Lupus Secondary to Sulfasalazine. [PDF]
CureusChoi K, Truong L, Kang Y.
europepmc +2 more sources