Results 21 to 30 of about 22,235 (292)
SIN3B, the SASP, and pancreatic cancer [PDF]
Molecular & Cellular Oncology, 2014 Cellular senescence is classically considered a tumor suppressive mechanism. In addition to having stably exited the cell cycle, senescent cells secrete inflammatory factors. We recently demonstrated that senescence correlates with accelerated cancer progression in a mouse model of pancreatic ductal adenocarcinoma.
Cantor, David J, David, Gregory
openaire +2 more sources
SASP regulation by noncoding RNA [PDF]
Mechanisms of Ageing and Development, 2017 Noncoding RNAs (ncRNAs), including micro (mi)RNAs, long noncoding (lnc)RNAs, and circular (circ)RNAs, control specific gene expression programs by regulating transcriptional, post-transcriptional, and post-translational processes. Through their broad influence on protein expression and function, ncRNAs have been implicated in virtually all cellular ...
Amaresh C, Panda +2 more
openaire +2 more sources
TORn about SASP regulation [PDF]
Cell Cycle, 2015 Senescence is a cellular response to stresses such as oncogenic signaling, DNA damage and telomere loss, characterized by a stable growth arrest.
Nicolás, Herranz +2 more
openaire +2 more sources
Defective mitochondria ignite the SASP [PDF]
Nature Reviews Molecular Cell Biology, 2020 Defective mitochondria in senescent cells activate a signalling pathway that promotes the senescence-associated secretory phenotype and inflammation.
openaire +2 more sources
Epiregulation of the SASP makes good neighbors
Nature Aging, 2021 The tumor microenvironment (TME) impacts different phases of tumor progression and therapy resistance. Zhang et al. show that senescent stromal cells activate an epigenetic program that controls the senescence-associated secretory phenotype and can be targeted to boost responses to chemotherapy.
Desbats, Maria Andrea +2 more
openaire +3 more sources
The role of cellular senescence and SASP in tumour microenvironment [PDF]
The FEBS Journal, 2022 Cellular senescence refers to a state of irreversible cell cycle arrest that can be induced by various cellular stresses and is known to play a pivotal role in tumour suppression. While senescence‐associated growth arrest can inhibit the proliferation of cancer‐prone cells, the altered secretory profile of senescent cells, termed the senescence ...
Masaki Takasugi +3 more
openaire +2 more sources
SASP-related genes upregulated in ALGS livers versus non-cholestatic controls.
, 2023 SASP-related genes upregulated in ALGS livers versus non-cholestatic controls.
Mustapha Najimi (143882) +6 more
core +1 more source
Dissecting cellular senescence and SASP in Drosophila [PDF]
Inflammation and Regeneration, 2016 Cellular senescence can act as both tumor suppressor and tumor promoter depending on the cellular contexts. On one hand, premature senescence has been considered as an innate host defense mechanism against carcinogenesis in mammals. In response to various stresses including oxidative stress, DNA damage, and oncogenic stress, suffered cells undergo ...
Ito, Takao, Igaki, Tatsushi
openaire +2 more sources
GH Is a Component of SASP in Aging Tissue [PDF]
Journal of the Endocrine Society, 2021 Abstract Deficient GH signaling results in lifespan extension in murine and human models, while patients with uncontrolled acromegaly and transgenic mice overexpressing GH have a shorter lifespan. Colon polyp development increases with age, and also with GH excess in acromegaly.
Chesnokova, Vera M +4 more
openaire +1 more source
Engineered Bacteriophage as a Delivery Vehicle for Antibacterial Protein, SASP [PDF]
Pharmaceuticals, 2021 The difficulties in developing novel classes of antibacterials is leading to a resurgence of interest in bacteriophages as therapeutic agents, and in particular engineered phages that can be optimally designed. Here, pre-clinical microbiology assessment is presented of a Staphylococcus aureus phage engineered to deliver a gene encoding an antibacterial
James Cass +2 more
openaire +3 more sources