Results 21 to 30 of about 26,150 (274)

Mitochondrial RNA cytosolic leakage drives the SASP

Nature Communications
Senescent cells secrete proinflammatory factors known as the senescence-associated secretory phenotype (SASP), contributing to tissue dysfunction and aging. Mitochondrial dysfunction is a key feature of senescence, influencing SASP via mitochondrial DNA (
Stella Victorelli, Madeline Eppard, Hélène Martini, Seung-Hwa Woo, Stacia P. A. Everts, Gung Lee, Nicholas Pirius, Nuan Han, Eugene Y. Liang, Ana Catarina Franco, Yeaeun Han, Dominik Saul, Eva Nóvoa, Rubén Nogueiras, Patrick L. Splinter, Steven P. O’Hara, Olivia Morgenthaler, Lucía Valenzuela-Pérez, Hyun Se Kim Lee, Diana Jurk, Nicholas F. LaRusso, Petra Hirsova, João F. Passos   +22 more
doaj   +5 more sources

Senescence and SASP Are Potential Therapeutic Targets for Ischemic Stroke

Pharmaceuticals
Aging is a known co-morbidity of ischemic stroke with its risk and severity increasing every year past 55+. While many of the current stroke therapies have shown success in reducing mortality, post-stroke morbidity has not seen the same substantial ...
Blake Ouvrier, Gregory Jaye Bix, Saifudeen Ismael   +2 more
core   +4 more sources

Targeting senescence-associated secretory phenotype macrophage: apigenin inhibits DOT1L-dependent H3K79me2 at IL1A to fight SASP in senescent macrophages

Frontiers in Molecular Biosciences
IntroductionApigenin (API) has been utilized in the treatment of atherosclerosis. Senescent macrophages exhibit a senescence-associated secretory phenotype (SASP), which plays a critical role in the progression of atherosclerosis.
Guozhen Ni, Ning Ma, Jian Xu
doaj   +2 more sources

Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature [PDF]

European Journal of Medical Research
The senescence-associated secretory phenotype (SASP) is a generic term for the secretion of cytokines, such as pro-inflammatory factors and proteases. It is a crucial feature of senescent cells.
Shangkun Zhao, Zhi Qiao, Roman Pfeifer, Hans-Christoph Pape, Keya Mao, Hai Tang, Bin Meng, Songfeng Chen, Hongjian Liu   +8 more
doaj   +2 more sources

Cationic local composition fluctuations in rapidly cooled nuclear fuel melts

Nuclear Materials and Energy, 2022
During a severe accident in a nuclear reactor, as it occurred in Fukushima Daiichi BWRs in 2011, the so-called “corium” resulting from the thermal fusion of nuclear fuel and interaction with the zircaloy cladding at high temperature (T > 2800 K) can be ...
Mohamed Jizzini, Emmanuelle Brackx, Pascal Piluso, Denis Menut, René Guinebretière   +4 more
doaj   +1 more source

Apoptotic stress causes mtDNA release during senescence and drives the SASP [PDF]

, 2023
\ua9 2023, The Author(s). Senescent cells drive age-related tissue dysfunction partially through the induction of a chronic senescence-associated secretory phenotype (SASP)1.
Riley JS, Salmonowicz H, Cloix C, Hall-Younger E, Sales Gomez L, Tait SWG, Saul D, Huang H, Reed R, Passos JF, Martini H, Machado Espindola-Netto J, Eppard M, Pirius N, Greaves LC, LeBrasseur NK, Porritt RA, Dou Z, Szczepanowska K, Vizioli MG, Kelly G, Kaufmann SH, Zacharioudakis E, Farr JN, Shadel GS, Masuda CA, Jurk D, Adams PD, Huang TY, Gavathiotis E, Lagnado AB, Mann DA, Sainz AG, Victorelli S, Lei X, Khosla S, Korolchuk VI, Chapman J, Dai H   +38 more
core   +6 more sources

SASP regulation by noncoding RNA [PDF]

Mechanisms of Ageing and Development, 2017
Noncoding RNAs (ncRNAs), including micro (mi)RNAs, long noncoding (lnc)RNAs, and circular (circ)RNAs, control specific gene expression programs by regulating transcriptional, post-transcriptional, and post-translational processes. Through their broad influence on protein expression and function, ncRNAs have been implicated in virtually all cellular ...
Amaresh C, Panda, Kotb, Abdelmohsen, Myriam, Gorospe   +2 more
openaire   +2 more sources

NOTCH and the 2 SASPs of senescence [PDF]

Cell Cycle, 2016
The previous view that cellular senescence represented a stress-responsive tumor suppressor mechanism has been significantly revised recently with recognition of the profound non-autonomous functio...
Hoare, Matthew, Narita, Masashi
openaire   +2 more sources

SIN3B, the SASP, and pancreatic cancer [PDF]

Molecular & Cellular Oncology, 2014
Cellular senescence is classically considered a tumor suppressive mechanism. In addition to having stably exited the cell cycle, senescent cells secrete inflammatory factors. We recently demonstrated that senescence correlates with accelerated cancer progression in a mouse model of pancreatic ductal adenocarcinoma.
Cantor, David J, David, Gregory
openaire   +2 more sources

TORn about SASP regulation [PDF]

Cell Cycle, 2015
Senescence is a cellular response to stresses such as oncogenic signaling, DNA damage and telomere loss, characterized by a stable growth arrest.
Nicolás, Herranz, Suchira, Gallage, Jesús, Gil   +2 more
openaire   +2 more sources