Erciyes Medical Journal, 2019 Objective: In the present study we aim to evaluate whether some of the proteins previously identified in the secretome of senescent bone marrow (BM)- and adipose (A)-mesenchymal stromal cells (MSCs) could be involved in regulation of senescence phenomena.
Tiziana Squillaro +7 more
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Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. [PDF]
, 2020 The accumulation of senescent cells (SnCs) is a causal factor of various age-related diseases as well as some of the side effects of chemotherapy. Pharmacological elimination of SnCs (senolysis) has the potential to be developed into novel therapeutic ...
Budamagunta, Vivekananda +9 more
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Probiotic bacteria as modulators of cellular senescence: emerging concepts and opportunities
Gut Microbes, 2020 Probiotic bacteria are increasingly gaining importance in human nutrition owing to their multifaceted health beneficial effects. Studies have also shown that probiotic supplementation is useful in mitigating age-associated oxi-inflammatory stress ...
Rohit Sharma, Yogendra Padwad
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Cells, 2020 Immunosenescence in monocytes has been shown to be associated with several biochemical and functional changes, including development of senescence-associated secretory phenotype (SASP), which may be inhibited by klotho protein.
Jennifer Mytych +6 more
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Senescence-associated secretory phenotype and its impact on oral immune homeostasis
Frontiers in Immunology, 2022 The senescence-associated secretory phenotype (SASP), which accumulates over the course of normal aging and in age-related diseases, is a crucial driver of chronic inflammation and aging phenotypes. It is also responsible for the pathogenesis of multiple
Ziqi Yue +12 more
doaj +1 more source
Cytoplasmic chromatin triggers inflammation in senescence and cancer [PDF]
, 2017 Chromatin is traditionally viewed as a nuclear entity that regulates gene expression and silencing. However, we recently discovered the presence of cytoplasmic chromatin fragments that pinch off from intact nuclei of primary cells during senescence, a ...
Adams, Peter D. +23 more
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Bone marrow senescence and the microenvironment of hematological malignancies [PDF]
, 2020 Senescence is the irreversible arrest of cell proliferation that has now been shown to play an important role in both health and disease. With increasing age senescent cells accumulate throughout the body, including the bone marrow and this has been ...
Bowles, Kristian M. +3 more
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Teacher fabrication as an impediment to professional learning and development: the external mentor antidote [PDF]
, 2013 This paper reports findings from a study of the work of 'external mentors' associated with three programmes of support for the professional learning and development (PLD) of secondary science teachers in England.
Andrew J. Hobson +34 more
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RUNX-mediated growth arrest and senescence are attenuated by diverse mechanisms in cells expressing RUNX1 fusion oncoproteins [PDF]
, 2018 RUNX gene over-expression inhibits growth of primary cells but transforms cells with tumor suppressor defects, consistent with reported associations with tumor progression.
Anderson, Gail +10 more
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RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis [PDF]
, 2016 Tumor suppression that is mediated by oncogene-induced senescence (OIS) is considered to function as a safeguard during development of pancreatic ductal adenocarcinoma (PDAC). However, the mechanisms that regulate OIS in PDAC are poorly understood. Here,
Algül, Hana +17 more
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