Overcoming the senescence‐associated secretory phenotype (SASP): a complex mechanism of resistance in the treatment of cancer [PDF]
Molecular Oncology, 2021 Senescence is a cellular state in which cells undergo persistent cell cycle arrest in response to nonlethal stress. In the treatment of cancer, senescence induction is a potent method of suppressing tumour cell proliferation. In spite of this, senescent cancer cells and adjacent nontransformed cells of the tumour microenvironment can remain ...
Cecilia R Chambers +2 more
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ROCK inhibition modulates the senescence‐associated secretory phenotype (SASP) in oral keratinocytes [PDF]
FEBS Open Bio, 2020 Senescent cells accumulate in different organs and develop a senescence‐associated secretory phenotype (SASP), associated with the development of age‐related pathologies. The constitution of the SASP varies among cell types and with the method of senescence induction; nevertheless, there is substantial overlap among SASPs, especially the presence of ...
Sven Niklander +2 more
exaly +7 more sources
The controversial role of senescence-associated secretory phenotype (SASP) in cancer therapy [PDF]
Molecular CancerCellular senescence, characterized by partially irreversible cell cycle arrest, has a dual role in cancer progression via the senescence-associated secretory phenotype (SASP). SASP encompasses a wide range of bioactive chemicals, including cytokines, chemokines, growth factors, and proteases, all of which can have a significant impact on the tumor ...
Qiang Tong, Tong Qiang
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The roles and mechanisms of senescence-associated secretory phenotype (SASP): can it be controlled by senolysis? [PDF]
Inflammation and Regeneration, 2022 Cellular senescence is a state of irreversible cell cycle arrest that can be induced by a variety of potentially oncogenic stimuli, including DNA damage.
Naoko Ohtani
doaj +4 more sources
The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related Diseases [PDF]
Biology, 2020 Cellular senescence represents a robust tumor-protecting mechanism that halts the proliferation of stressed or premalignant cells. However, this state of stable proliferative arrest is accompanied by the Senescence-Associated Secretory Phenotype (SASP), which entails the copious secretion of proinflammatory signals in the tissue microenvironment and ...
Fabrizio Antonangeli +2 more
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Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase [PDF]
Metabolism: Clinical and Experimental, 2019 Disturbed flow (d-flow)-induced senescence and activation of endothelial cells (ECs) have been suggested to have critical roles in promoting atherosclerosis. Telomeric repeat-binding factor 2 (TERF2)-interacting protein (TERF2IP), a member of the shelterin complex at the telomere, regulates the senescence-associated secretory phenotype (SASP), in which
Sivareddy Kotla +2 more
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Senescent Endothelial Cells Sustain Their Senescence-Associated Secretory Phenotype (SASP) through Enhanced Fatty Acid Oxidation [PDF]
Antioxidants, 2023 Cellular senescence is closely linked to endothelial dysfunction, a key factor in age-related vascular diseases. Senescent endothelial cells exhibit a proinflammatory phenotype known as SASP, leading to chronic inflammation (inflammaging) and vascular impairments.
Angelica Giuliani +2 more
exaly +5 more sources
The microRNA-34a-Induced Senescence-Associated Secretory Phenotype (SASP) Favors Vascular Smooth Muscle Cells Calcification [PDF]
International Journal of Molecular Sciences, 2020 The senescence of vascular smooth muscle cells (VSMCs), characterized by the acquisition of senescence-associated secretory phenotype (SASP), is relevant for VSMCs osteoblastic differentiation and vascular calcification (VC). MicroRNA-34a (miR-34a) is a driver of such phenomena and could play a role in vascular inflammaging.
Ileana Badi +2 more
exaly +5 more sources
The role of senescence-associated secretory phenotype (SASP) in cellular senescene
Acta Biochimica Indonesiana, 2021 Cellular senescence is one of the defense mechanisms of cells against oncogenic signals by permanently stopping the proliferation of the cell. Senescence cells show a similar characteristic, one of them is senescence-associated secretory phenotype (SASP).
Filda Vionita Irene de Lime +1 more
doaj +3 more sources
Sensitive detection and monitoring of senescence-associated secretory phenotype by SASP-RAP assay. [PDF]
PLoS ONE, 2012 Senescence-associated secretory phenotype (SASP) is characterized by abundant secretion of various proteins in senescent cells and implicated in tumor progression and inflammatory responses.
Liubao Gu, Masanori Kitamura
doaj +4 more sources