Results 11 to 20 of about 21,370 (250)

The controversial role of senescence-associated secretory phenotype (SASP) in cancer therapy. [PDF]

Mol Cancer
Cao L, Li K, Li Q, Tong Q, Wang Y, Huang L.   +5 more
europepmc   +3 more sources

Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase. [PDF]

Metabolism, 2019
Disturbed flow (d-flow)-induced senescence and activation of endothelial cells (ECs) have been suggested to have critical roles in promoting atherosclerosis. Telomeric repeat-binding factor 2 (TERF2)-interacting protein (TERF2IP), a member of the shelterin complex at the telomere, regulates the senescence-associated secretory phenotype (SASP), in which
Kotla S, Le NT, Vu HT, Ko KA, Gi YJ, Thomas TN, Giancursio C, Lusis AJ, Cooke JP, Fujiwara K, Abe JI.   +10 more
europepmc   +5 more sources

The role of senescence-associated secretory phenotype (SASP) in cellular senescene

Acta Biochimica Indonesiana, 2021
Cellular senescence is one of the defense mechanisms of cells against oncogenic signals by permanently stopping the proliferation of the cell. Senescence cells show a similar characteristic, one of them is senescence-associated secretory phenotype (SASP).
Filda Vionita Irene de Lime, Novi Silvia Hardiany   +1 more
doaj   +3 more sources

Overcoming the senescence-associated secretory phenotype (SASP): a complex mechanism of resistance in the treatment of cancer. [PDF]

Mol Oncol, 2021
Senescence is a cellular state in which cells undergo persistent cell cycle arrest in response to nonlethal stress. In the treatment of cancer, senescence induction is a potent method of suppressing tumour cell proliferation. In spite of this, senescent cancer cells and adjacent nontransformed cells of the tumour microenvironment can remain ...
Chambers CR, Ritchie S, Pereira BA, Timpson P.   +3 more
europepmc   +6 more sources

Sensitive detection and monitoring of senescence-associated secretory phenotype by SASP-RAP assay. [PDF]

PLoS ONE, 2012
Senescence-associated secretory phenotype (SASP) is characterized by abundant secretion of various proteins in senescent cells and implicated in tumor progression and inflammatory responses.
Liubao Gu, Masanori Kitamura
doaj   +4 more sources

Inside and out: the activities of senescence in cancer. [PDF]

Nature Reviews Cancer, 2014
The core aspect of the senescent phenotype is a stable state of cell cycle arrest. However, this is a disguise that conceals a highly active metabolic cell state with diverse functionality.
A Alimonti, A Chuprin, A Iannello, A Krtolica, A Lujambio, A Pribluda, A Shamma, A Takamura, A Ventura, AJ Millis, AM Leidal, Andrew R. J. Young, AR Davalos, ARJ Young, AV Knizhnik, AV Orjalo, AW Lin, B Quesnel, BD Chang, BJ Nickoloff, BJ Nickoloff, BJ Nickoloff, BY Lee, C Bavik, C Feig, C Gewinner, C Guerra, C Lu, C López-Otín, C Michaloglou, C Nardella, C Quijano, C-H Chan, C-H Wu, CA Schmitt, CB Harley, CE Burd, CP Martins, D Muñoz-Espín, DA Gewirtz, DA Gewirtz, DA Tuveson, DH Raulet, DJ Baker, DJ Baker, DM Feldser, E Elinav, E González-Suárez, E Lazzerini Denchi, ED Michelakis, F D'adda Di Fagagna, F D'adda Di Fagagna, F Janku, F Rodier, F Vazquez, FG Giancotti, G Bergers, G Mariño, G Mosieniak, G Willimsky, G Yang, H Braumüller, H Kondoh, H-K Lin, HT Kang, J Campisi, J Campisi, J Eyles, J Kaplon, J St-Pierre, J Zhu, J-G Ren, J-I Jun, J-P Coppé, J-P Coppé, JA Ewald, JC Acosta, JC Acosta, JC Acosta, JF Passos, JF Passos, JG Jackson, JR Dörr, JY Guo, JY Guo, K Rakhra, K-H Kim, KL Rudolph, KR Patel, L Hayflick, L Hayflick, L Hoenicke, L Qi, L Soucek, L-M Gerland, LG Baggetto, LL Scurr, M Braig, M Collado, M Collado, M Hoare, M Hoare, M Narita, M Puyol, M Qi, M Qi, M Reimann, M Serrano, M Storer, M Wall, MA Blasco, Masashi Narita, MS Song, MT Rosenfeldt, N Draoui, N Mizushima, N Müller-Hermelink, N Wajapeyee, N Wajapeyee, NE Sharpless, O Casanovas, O Moiseeva, P Jiang, P Sousa-Victor, Pedro A. Pérez-Mancera, PI Poulikakos, R Haq, R Lengagne, R Salama, RA Dickins, RA Greenberg, RH Poele te, RK Amaravadi, RK Amaravadi, RM Kortlever, RW Goehe, S Bonnet, S Campaner, S Courtois-Cox, S Goldstein, S Hubackova, S Parrinello, S Patschan, S Yoshimoto, SL Friedman, T Kuilman, T Kuilman, T Kuilman, T Schlomm, T-W Kang, U Herbig, V Krizhanovsky, VI Korolchuk, VJ Cristofalo, W Xue, WG Kaelin, WH Koppenol, X Qu, Y Chien, Y Wang, Z Chen, Z Yue, ZJ Yang   +162 more
core   +3 more sources

ROCK inhibition modulates the senescence-associated secretory phenotype (SASP) in oral keratinocytes. [PDF]

FEBS Open Bio, 2020
Senescent cells accumulate in different organs and develop a senescence‐associated secretory phenotype (SASP), associated with the development of age‐related pathologies. The constitution of the SASP varies among cell types and with the method of senescence induction; nevertheless, there is substantial overlap among SASPs, especially the presence of ...
Niklander S, Bandaru D, Lambert DW, Hunter KD.   +3 more
europepmc   +5 more sources

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype [PDF]

Nature Cell Biology, 2015
Senescent cells secrete a combination of factors collectively known as the senescence-associated secretory phenotype (SASP). The SASP reinforces senescence and activates an immune surveillance response, but it can also show pro-tumorigenic properties and
Acosta, JC, Banito, A, Carroll, T, Cutillas, P, Dharmalingam, G, Faull, P, Gallage, S, Georgilis, A, Gill, J, Hanley, CJ, Heikenwalder, M, Herranz, N, Innes, AJ, Klotz, S, Martinez-Barbera, JP, Mellone, M, Miller, RA, Montoya, A, Raguz, S, Reisinger, F, Thomas, GJ, Withers, D, Wolter, K, Wuestefeld, T, Zender, L   +24 more
core   +4 more sources

Senescent Endothelial Cells Sustain Their Senescence-Associated Secretory Phenotype (SASP) through Enhanced Fatty Acid Oxidation [PDF]

Antioxidants (Basel), 2023
Cellular senescence is closely linked to endothelial dysfunction, a key factor in age-related vascular diseases. Senescent endothelial cells exhibit a proinflammatory phenotype known as SASP, leading to chronic inflammation (inflammaging) and vascular impairments.
Giuliani A, Giudetti A, Vergara D, Del Coco L, Ramini D, Caccese S, Sbriscia M, Graciotti L, Fulgenzi G, Tiano L, Fanizzi F, Olivieri F, Rippo M, Sabbatinelli J.   +13 more
europepmc   +4 more sources

The microRNA-34a-Induced Senescence-Associated Secretory Phenotype (SASP) Favors Vascular Smooth Muscle Cells Calcification. [PDF]

Int J Mol Sci, 2020
The senescence of vascular smooth muscle cells (VSMCs), characterized by the acquisition of senescence-associated secretory phenotype (SASP), is relevant for VSMCs osteoblastic differentiation and vascular calcification (VC). MicroRNA-34a (miR-34a) is a driver of such phenomena and could play a role in vascular inflammaging.
Zuccolo E, Badi I, Scavello F, Gambuzza I, Mancinelli L, Macrì F, Tedesco CC, Veglia F, Bonfigli AR, Olivieri F, Raucci A.   +10 more
europepmc   +4 more sources