Results 11 to 20 of about 10,262,985 (255)

COPD-derived fibroblasts secrete higher levels of senescence-associated secretory phenotype proteins [PDF]

Thorax, 2021
COPD-derived fibroblasts have increased cellular senescence. Senescent cell accumulation can induce tissue dysfunction by their senescence-associated secretory phenotype (SASP).
Heijink, Irene H, Woldhuis, Roy R; id_orcid, Timens, Wim; id_orcid, de Vries, Maaike, van den Berge, Maarten, Brandsma, Corry-Anke; id_orcid, Brandsma, Corry-Anke, Oliver, Brian G G, Woldhuis, Roy R, van den Berge, Maarten; id_orcid, Timens, Wim   +10 more
core   +8 more sources

Senescent Endothelial Cells Sustain Their Senescence-Associated Secretory Phenotype (SASP) Through Enhanced Fatty Acid Oxidation [PDF]

Antioxidants, 2023
Cellular senescence is closely linked to endothelial dysfunction, a key factor in age-related vascular diseases. Senescent endothelial cells exhibit a proinflammatory phenotype known as SASP, leading to chronic inflammation (inflammaging) and vascular impairments.
Deborah Ramini, Jacopo Sabbatinelli, Laura Graciotti   +2 more
exaly   +5 more sources

Targeting senescence-associated secretory phenotype macrophage: apigenin inhibits DOT1L-dependent H3K79me2 at IL1A to fight SASP in senescent macrophages

Frontiers in Molecular Biosciences
IntroductionApigenin (API) has been utilized in the treatment of atherosclerosis. Senescent macrophages exhibit a senescence-associated secretory phenotype (SASP), which plays a critical role in the progression of atherosclerosis.
Guozhen Ni, Ning Ma, Jian Xu
doaj   +2 more sources

Recent advances in senescence-associated secretory phenotype and osteoporosis

Heliyon
The worldwide elderly population is on the rise, and aging is a major osteoporosis risk factor. Senescent cells accumulation can have a detrimental effect the body as we age.
Haonan Fan, Zhi Qiao, Jitian Li, Guowei Shang, Chunfeng Shang, Songfeng Chen, Zikuan Leng, Huifang Su, Hongwei Kou, Hongjian Liu   +9 more
doaj   +2 more sources

Mechanisms and therapeutic strategies for senescence-associated secretory phenotype in the intervertebral disc degeneration microenvironment

Journal of Orthopaedic Translation
As a permanent state of cell cycle arrest, cellular senescence has become an important factor in aging and age-related diseases. As a central regulator of physiology and pathology associated with cellular senescence, the senescence associated secretory ...
Yang Liu, Yiming Dou, Xun Sun, Qiang Yang   +3 more
doaj   +2 more sources

Senescence-associated prostate cancer cells promote fibroblast reprogramming and extracellular matrix remodeling [PDF]

Neoplasia: An International Journal for Oncology Research
Background: Cellular senescence influences tumor progression via the senescence-associated secretory phenotype (SASP), yet whether senescence-associated alterations in prostate epithelial cells contribute to stromal remodeling remains poorly understood ...
Chongsen Lin, Qianyu Guo, Shaohong Lai
doaj   +2 more sources

A Review of Senescence‐Associated Secretory Phenotype‐Mediated Remodeling of the Tumor Microenvironment: Implications for Cancer Progression and Therapy [PDF]

Cancer Reports
Background Cellular senescence influences cancer progression through irreversible cell‐cycle arrest, immune surveillance, and paracrine signaling mediated by the senescence‐associated secretory phenotype (SASP).
Sneha Pallatt, Sibin Nambidi, Antara Banerjee, Surajit Pathak   +3 more
doaj   +2 more sources

ACSS2 drives senescence-associated secretory phenotype by limiting purine biosynthesis through PAICS acetylation

Nature Communications
Senescence-associated secretory phenotype (SASP) mediates the biological effects of senescent cells on the tissue microenvironment and contributes to ageing-associated disease progression.
Li Yang, Jianwei You, Xincheng Yang, Ruishu Jiao, Jie Xu, Yue zhang, Wen Mi, Lingzhi Zhu, Youqiong Ye, Ruobing Ren, Delin Min, Meilin Tang, Li Chen, Fuming Li, Pingyu Liu   +14 more
doaj   +2 more sources

CXCL5-CXCR2 signaling is a senescence-associated secretory phenotype in preimplantation embryos [PDF]

, 2022
Pregnancy rate of women decreases with age due to declining quality of oocytes and embryos. However, there is no established method to improve pregnancy rate in aging women.
KAWAMURA, Kazuhiro, KAWASHIMA, Ikko, SATO, Yorino, MATSUBARA, Kazuei, KAWAGOE, Yuta, OKAMOTO, Naoki   +5 more
core   +2 more sources

Cell enlargement modulated by GATA4 and YAP instructs the senescence-associated secretory phenotype

Nature Communications
Dynamic changes in cell size are associated with development and pathological conditions, including aging. Although cell enlargement is a prominent morphological feature of cellular senescence, its functional implications are unknown; moreover, how ...
Joae Joung, Yekang Heo, Yeonju Kim, Jaejin Kim, Haebeen Choi, Taerang Jeon, Yeji Jang, Eun-Jung Kim, Sang Heon Lee, Jae Myoung Suh, Stephen J. Elledge, Mi-Sung Kim, Chanhee Kang   +12 more
doaj   +2 more sources