Results 11 to 20 of about 16,073 (137)

Late Depression and Senescence-Associated Secretory Phenotype (SASP) [PDF]

Eur Psychiatry
IntroductionNeurobiological mechanisms of late depression include abnormal regulation and interaction of multiple biological processes, as well as abnormalities of brain structures and organs.Objectivesliterature analysisMethodsgeneral scientific methodResultsThe results of the study show that the SASP index as an integral indicator of changes in ...
Sidenkova A.
europepmc   +2 more sources

Myeloma-Modified Adipocytes Exhibit Metabolic Dysfunction and a Senescence-Associated Secretory Phenotype. [PDF]

Cancer Res, 2021
Abstract Bone marrow adipocytes (BMAd) have recently been implicated in accelerating bone metastatic cancers, such as acute myelogenous leukemia and breast cancer. Importantly, bone marrow adipose tissue (BMAT) expands with aging and obesity, two key risk factors in multiple myeloma disease ...
Fairfield H, Dudakovic A, Khatib CM, Farrell M, Costa S, Falank C, Hinge M, Murphy CS, DeMambro V, Pettitt JA, Lary CW, Driscoll HE, McDonald MM, Kassem M, Rosen C, Andersen TL, van Wijnen AJ, Jafari A, Reagan MR.   +18 more
europepmc   +6 more sources

The Impact of Senescence-Associated Secretory Phenotype (SASP) on Head and Neck Cancers: From Biology to Therapy. [PDF]

Cancers (Basel)
Cellular senescence is defined as a state of permanent cell cycle arrest, providing a natural barrier against cancer. However, senescent cells are very metabolically active and secrete a complex mixture of bioactive molecules collectively known as the senescence-associated secretory phenotype (SASP), which play a dual role in cancer biology.
Alam MT, Mansoor MAM, Ashiqueali SA, Golusinski P, Golusinska-Kardach E, Strzelczyk JK, Rubis B, Golusinski W, Masternak MM.   +8 more
europepmc   +3 more sources

Modulation of fracture healing by senescence-associated secretory phenotype (SASP): a narrative review of the current literature. [PDF]

Eur J Med Res
AbstractThe senescence-associated secretory phenotype (SASP) is a generic term for the secretion of cytokines, such as pro-inflammatory factors and proteases. It is a crucial feature of senescent cells. SASP factors induce tissue remodeling and immune cell recruitment.
Zhao S, Qiao Z, Pfeifer R, Pape HC, Mao K, Tang H, Meng B, Chen S, Liu H.   +8 more
europepmc   +5 more sources

Single-cell transcriptomics identifies senescence-associated secretory phenotype (SASP) features of testicular aging in human. [PDF]

Aging (Albany NY)
The male reproductive system experiences degradation with age, predominantly impacting the testes. Testicular aging can result in failure to produce physiological testosterone levels, normal sperm concentrations, or both. However, we cannot predict the onset of testicular aging in advance.
He J, Li J, Li Y, Xu Z, Ma M, Chen H, Chen P, Lv L, Shang X, Liu G.   +9 more
europepmc   +3 more sources

Optimisation of a screening platform for determining IL-6 inflammatory signalling in the senescence-associated secretory phenotype (SASP). [PDF]

Biogerontology, 2019
Cellular senescence has been shown to be sufficient for the development of multiple age-related pathologies. Senescent cells adopt a secretory phenotype (the SASP) which comprises a large number of pro-inflammatory cytokines, chemokines and proteases. The SASP itself is thought to be causative in many pathologies of age-related diseases, and there is ...
Rolt A, Nair A, Cox LS.
europepmc   +5 more sources

Folic Acid Supplementation Suppresses Sleep Deprivation-Induced Telomere Dysfunction and Senescence-Associated Secretory Phenotype (SASP). [PDF]

Oxid Med Cell Longev, 2019
Sleep deprivation is reported to cause oxidative stress and is hypothesized to induce subsequent aging-related diseases including chronic inflammation, Alzheimer’s disease, and cardiovascular disease. However, how sleep deprivation contributes to the pathogenesis of sleep deficiency disorder remains incompletely defined.
Zhang X, Wang Y, Zhao R, Hu X, Zhang B, Lv X, Guo Z, Zhang Z, Yuan J, Chu X, Wang F, Li G, Geng X, Liu Y, Sui L, Wang F.   +15 more
europepmc   +3 more sources

A Senescence Associated Secretory Phenotype (SASP) in Indolent Systemic Mastocytosis Compared to Healthy Controls [PDF]

Innov Aging
Abstract Indolent systemic mastocytosis (ISM) is a disease characterized by an abnormal proliferation and hyperactivity of neoplastic mast cells in bone marrow and various organ systems, marked by high rates of cognitive dysfunction, musculoskeletal deterioration, and chronic fatigue; clinical manifestations commonly associated with ...
Nicoloro-Santabarbara, Jennifer, Ravindran, Rohan, Giannetti, Matthew, Dwyer, Dan, Lam, Michael, Lee, Pui, Castells, Marianna, Carroll, Judith   +7 more
europepmc   +3 more sources

Senescence‐associated secretory phenotype (SASP) index in individuals across the Alzheimer’s disease continuum [PDF]

Alzheimers Dement
AbstractBackgroundCellular senescence (CS) is a hallmark of aging. Senescence‐associated secretory phenotype (SASP) index was recently developed based on the levels of blood SASP‐related proteins. Although aging is a primary risk factor for Alzheimer's disease (AD), the role of CS in this neurodegenerative condition is not well understood.
Franco A, Schlickmann T, Ferrari‐Souza J, de Bastiani M, Castilhos R, Zimmer E.   +5 more
europepmc   +2 more sources

Senescence-associated secretory phenotype (SASP) and uterine fibroids: Association with PD-L1 activation and collagen deposition. [PDF]

Ageing Res Rev
Uterine fibroids (or uterine leiomyoma, UFs) are one of the most prevalent benign uterine tumors with high proliferation and collagen synthesis capabilities. UFs are a significant worldwide health issue for women, affecting their physical and financial well-being.
Saad EE, Michel R, Borahay MA.
europepmc   +3 more sources