The controversial role of senescence-associated secretory phenotype (SASP) in cancer therapy [PDF]
Molecular CancerCellular senescence, characterized by partially irreversible cell cycle arrest, has a dual role in cancer progression via the senescence-associated secretory phenotype (SASP). SASP encompasses a wide range of bioactive chemicals, including cytokines, chemokines, growth factors, and proteases, all of which can have a significant impact on the tumor ...
Qiang Tong
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The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related Diseases [PDF]
Biology, 2020 Cellular senescence represents a robust tumor-protecting mechanism that halts the proliferation of stressed or premalignant cells. However, this state of stable proliferative arrest is accompanied by the Senescence-Associated Secretory Phenotype (SASP), which entails the copious secretion of proinflammatory signals in the tissue microenvironment and ...
Alessandra Soriani +2 more
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Overcoming the senescence‐associated secretory phenotype (SASP): a complex mechanism of resistance in the treatment of cancer [PDF]
Molecular Oncology, 2021 Senescence is a cellular state in which cells undergo persistent cell cycle arrest in response to nonlethal stress. In the treatment of cancer, senescence induction is a potent method of suppressing tumour cell proliferation. In spite of this, senescent cancer cells and adjacent nontransformed cells of the tumour microenvironment can remain ...
Paul Timpson, Brooke Pereira
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The microRNA-34a-Induced Senescence-Associated Secretory Phenotype (SASP) Favors Vascular Smooth Muscle Cells Calcification [PDF]
International Journal of Molecular Sciences, 2020 The senescence of vascular smooth muscle cells (VSMCs), characterized by the acquisition of senescence-associated secretory phenotype (SASP), is relevant for VSMCs osteoblastic differentiation and vascular calcification (VC). MicroRNA-34a (miR-34a) is a driver of such phenomena and could play a role in vascular inflammaging.
Ileana Badi +2 more
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Sensitive detection and monitoring of senescence-associated secretory phenotype by SASP-RAP assay. [PDF]
PLoS ONE, 2012 Senescence-associated secretory phenotype (SASP) is characterized by abundant secretion of various proteins in senescent cells and implicated in tumor progression and inflammatory responses.
Liubao Gu, Masanori Kitamura
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ROCK inhibition modulates the senescence-associated secretory phenotype (SASP) in oral keratinocytes. [PDF]
FEBS Open Bio, 2020 Senescent cells accumulate in different organs and develop a senescence‐associated secretory phenotype (SASP), associated with the development of age‐related pathologies. The constitution of the SASP varies among cell types and with the method of senescence induction; nevertheless, there is substantial overlap among SASPs, especially the presence of ...
Niklander S +3 more
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The roles and mechanisms of senescence-associated secretory phenotype (SASP): can it be controlled by senolysis? [PDF]
Inflammation and Regeneration, 2022 Cellular senescence is a state of irreversible cell cycle arrest that can be induced by a variety of potentially oncogenic stimuli, including DNA damage.
Naoko Ohtani
doaj +4 more sources
The Impact of Senescence-Associated Secretory Phenotype (SASP) on Head and Neck Cancers: From Biology to Therapy [PDF]
CancersCellular senescence is defined as a state of permanent cell cycle arrest, providing a natural barrier against cancer. However, senescent cells are very metabolically active and secrete a complex mixture of bioactive molecules collectively known as the senescence-associated secretory phenotype (SASP), which play a dual role in cancer biology.
Joanna Katarzyna Strzelczyk +2 more
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Senescent Endothelial Cells Sustain Their Senescence-Associated Secretory Phenotype (SASP) through Enhanced Fatty Acid Oxidation [PDF]
Antioxidants, 2023 Cellular senescence is closely linked to endothelial dysfunction, a key factor in age-related vascular diseases. Senescent endothelial cells exhibit a proinflammatory phenotype known as SASP, leading to chronic inflammation (inflammaging) and vascular impairments.
Deborah Ramini +2 more
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Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase [PDF]
Metabolism: Clinical and Experimental, 2019 Disturbed flow (d-flow)-induced senescence and activation of endothelial cells (ECs) have been suggested to have critical roles in promoting atherosclerosis. Telomeric repeat-binding factor 2 (TERF2)-interacting protein (TERF2IP), a member of the shelterin complex at the telomere, regulates the senescence-associated secretory phenotype (SASP), in which
Jun-Ichi Abe +2 more
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