Results 41 to 50 of about 8,456,945 (252)
Communications Biology, 2022 Type-2 diabetic adipose tissue impairs transient senescence during wound healing with expression of different components of the senescence-associated secretory phenotype (SASP), and this is associated with deteriorated wound healing.
Arisa Kita +8 more
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Nature Communications, 2023 Cellular senescence and associated secretory phenotype (SASP) are thought to contribute to aging and tissue dysfunction, though it is unclear how SASP impacts regeneration.
Jina Yun +18 more
doaj +1 more source
G3BP1 controls the senescence-associated secretome and its impact on cancer progression
Nature Communications, 2020 The mechanisms that control the deleterious behaviour of senescent cells is unclear. Here, the authors show that G3BP1 is required for the induction of the senescence-associated secretory phenotype (SASP), without affecting senescence, and that SASP ...
Amr Omer +6 more
doaj +1 more source
The long non-coding RNA MIR31HG regulates the senescence associated secretory phenotype
Nature Communications, 2021 Senescence-associated secretory phenotype (SASP) involves secretion of factors such as pro-inflammatory cytokines. Here the authors show that MIR31HG regulates the expression and secretion of a subset of SASP components that induce paracrine invasion ...
Marta Montes +9 more
doaj +1 more source
Senescence-associated extracellular vesicle release plays a role in senescence-associated secretory phenotype (SASP) in age-associated diseases [PDF]
The Journal of Biochemistry, 2020 Abstract Cellular senescence is an important tumour suppression mechanism that inhibits the proliferation of damaged cells. In senescent cells, irreparable DNA damage causes accumulation of genomic DNA fragments in the cytoplasm, which are recognized by the cyclic GMP-AMP synthase–stimulator of interferon gene pathway, resulting in ...
Yoko, Tanaka, Akiko, Takahashi
openaire +2 more sources
Redox control of senescence and age-related disease
Redox Biology, 2017 The signaling networks that drive the aging process, associated functional deterioration, and pathologies has captured the scientific community's attention for decades.
Akshaya Chandrasekaran +2 more
doaj +1 more source
, 2021 Original images and blots of Physiological hypoxia restrains the Senescence Associated Secretory Phenotype (SASP) via AMPK-mediated mTOR suppression.
Restoring Organ Function by Means of Regenerative Medicine (REGENERATE) +3 more
core +1 more source
Identification and study of a role for toll-like receptors in oncogene-induced senescence
, 2018 Oncogene-induced senescence (OIS) is a fail-safe mechanism activated to halt the proliferation of cells at risk of malignant transformation. It is a cell cycle arrest program of biological changes to the cell comprising of the activation of tumour ...
Hari, Priya
core +3 more sources
A Model for p38MAPK-Induced Astrocyte Senescence.
PLoS ONE, 2015 Experimental evidence indicates that aging leads to accumulation of senescent cells in tissues and they develop a secretory phenotype (also known as SASP, for senescence-associated secretory phenotype) that can contribute to chronic inflammation and ...
José C M Mombach +2 more
doaj +1 more source
HMGB2 holds the key to the senescence-associated secretory phenotype [PDF]
, 2016 The senescence - associated secretory phenotype (SASP) is a hallmark of senescence with important physiological impact, but how it is established is unclear . In this issue , Aird and colleagues ( 2016. J Cell Biol.
guerrero a, Gil, J
core +1 more source