Results 41 to 50 of about 17,888 (258)

The senescence-associated secretory phenotype (SASP) from mesenchymal stromal cells impairs growth of immortalized prostate cells but has no effect on metastatic prostatic cancer cells. [PDF]

Aging (Albany NY), 2019
Senescent cells secrete inflammatory cytokines, proteases, and other factors, which are indicated as senescence-associated secretory phenotype (SASP). There are contrasting studies on the role of the SASP in cancer.
Alessio N, Aprile D, Squillaro T, Di Bernardo G, Finicelli M, Melone MA, Peluso G, Galderisi U.   +7 more
europepmc   +3 more sources

HMGB2 holds the key to the senescence-associated secretory phenotype [PDF]

, 2016
The senescence - associated secretory phenotype (SASP) is a hallmark of senescence with important physiological impact, but how it is established is unclear . In this issue , Aird and colleagues ( 2016. J Cell Biol.
guerrero a, Gil, J
core   +1 more source

A Model for p38MAPK-Induced Astrocyte Senescence.

PLoS ONE, 2015
Experimental evidence indicates that aging leads to accumulation of senescent cells in tissues and they develop a secretory phenotype (also known as SASP, for senescence-associated secretory phenotype) that can contribute to chronic inflammation and ...
José C M Mombach, Bruno Vendrusculo, Cristhian A Bugs   +2 more
doaj   +1 more source

Pleiotropic effects of BAFF on the senescence-associated secretome and growth arrest

eLife, 2023
Senescent cells release a variety of cytokines, proteases, and growth factors collectively known as the senescence-associated secretory phenotype (SASP). Sustained SASP contributes to a pattern of chronic inflammation associated with aging and implicated
Martina Rossi, Carlos Anerillas, Maria Laura Idda, Rachel Munk, Chang Hoon Shin, Stefano Donega, Dimitrios Tsitsipatis, Allison B Herman, Jennifer L Martindale, Xiaoling Yang, Yulan Piao, Krystyna Mazan-Mamczarz, Jinshui Fan, Luigi Ferrucci, Peter F Johnson, Supriyo De, Kotb Abdelmohsen, Myriam Gorospe   +17 more
doaj   +1 more source

TWIST1 controls cellular senescence and energy metabolism in mesenchymal stem cells [PDF]

European Cells & Materials, 2021
Mesenchymal stem cells (MSCs) are promising cells for regenerative medicine therapies because they can differentiate towards multiple cell lineages. However, the occurrence of cellular senescence and the acquiring of the senescence-associated secretory ...
C Voskamp, LA Anderson, WJLM Koevoet, S Barnhoorn, PG Mastroberardino, GJVM van Osch, R Narcisi   +6 more
doaj   +1 more source

N-Acetyltransferase 10 Promotes Micronuclei Formation to Activate the Senescence-Associated Secretory Phenotype Machinery in Colorectal Cancer Cells

Translational Oncology, 2020
The formation of micronuclei (MN) is prevalent in human cancer cells and its role in activating the senescence-associated secretory phenotype (SASP) machinery has been identified recently.
Yanan Cao, Mengfei Yao, Yaqian Wu, Ningning Ma, Haijing Liu, Bo Zhang   +5 more
doaj   +1 more source

Cellular senescence and the tumour microenvironment

Molecular Oncology, 2022
The senescence‐associated secretory phenotype (SASP), where senescent cells produce a variety of secreted proteins including inflammatory cytokines, chemokines, matrix remodelling factors, growth factors and so on, plays pivotal but varying roles in the ...
Masaki Takasugi, Yuya Yoshida, Naoko Ohtani   +2 more
doaj   +1 more source

Paracrine Senescence of Mesenchymal Stromal Cells Involves Inflammatory Cytokines and the NF-κB Pathway

Cells, 2022
It has been known that senescence-associated secretory phenotype (SASP) triggers senescence of the surrounding normal cells. However, SASP signaling regarding mesenchymal stromal cell aging remains to be fully elucidated.
Lun-Yin Chou, Chun-Te Ho, Shih-Chieh Hung   +2 more
doaj   +1 more source

Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells

Nature Communications, 2018
Activation of DNA damage response induces the acquisition of senescence-associated secretory phenotype (SASP) in senescent cells, but precise mechanisms remain unclear.
Akiko Takahashi, Tze Mun Loo, Ryo Okada, Fumitaka Kamachi, Yoshihiro Watanabe, Masahiro Wakita, Sugiko Watanabe, Shimpei Kawamoto, Kenichi Miyata, Glen N. Barber, Naoko Ohtani, Eiji Hara   +11 more
doaj   +1 more source

MLL1 is essential for the senescence-associated secretory phenotype [PDF]

, 2016
Oncogene-induced senescence (OIS) and therapy-induced senescence (TIS), while tumor-suppressive, also promote procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflammation.
Shah, Parisha P., Capell, Brian C., Adams, Peter D., Simola, Daniel F., Natale, Christopher, Rai, Taranjit, Zhu, Jiajun, Donahue, Greg, Ridky, Todd W., Berger, Shelley L., Dou, Zhixun, Rai, Taranjit Singh, Dorsey, Jean, Drake, Adam M., Sammons, Morgan   +14 more
core   +1 more source