Results 41 to 50 of about 10,262,985 (255)

A Model for p38MAPK-Induced Astrocyte Senescence.

PLoS ONE, 2015
Experimental evidence indicates that aging leads to accumulation of senescent cells in tissues and they develop a secretory phenotype (also known as SASP, for senescence-associated secretory phenotype) that can contribute to chronic inflammation and ...
José C M Mombach, Bruno Vendrusculo, Cristhian A Bugs   +2 more
doaj   +1 more source

Senescence‐associated secretory phenotype (SASP) index in individuals across the Alzheimer’s disease continuum [PDF]

Alzheimers Dement
AbstractBackgroundCellular senescence (CS) is a hallmark of aging. Senescence‐associated secretory phenotype (SASP) index was recently developed based on the levels of blood SASP‐related proteins. Although aging is a primary risk factor for Alzheimer's disease (AD), the role of CS in this neurodegenerative condition is not well understood.
Franco A, Schlickmann T, Ferrari‐Souza J, de Bastiani M, Castilhos R, Zimmer E.   +5 more
europepmc   +2 more sources

Pleiotropic effects of BAFF on the senescence-associated secretome and growth arrest

eLife, 2023
Senescent cells release a variety of cytokines, proteases, and growth factors collectively known as the senescence-associated secretory phenotype (SASP). Sustained SASP contributes to a pattern of chronic inflammation associated with aging and implicated
Martina Rossi, Carlos Anerillas, Maria Laura Idda, Rachel Munk, Chang Hoon Shin, Stefano Donega, Dimitrios Tsitsipatis, Allison B Herman, Jennifer L Martindale, Xiaoling Yang, Yulan Piao, Krystyna Mazan-Mamczarz, Jinshui Fan, Luigi Ferrucci, Peter F Johnson, Supriyo De, Kotb Abdelmohsen, Myriam Gorospe   +17 more
doaj   +1 more source

SASP Atlas: A comprehensive resource for SASPs.

, 2020
SASP Atlas (www.SASPAtlas.com) is a curated and freely available database of the secretomes of senescent cells, including both the soluble and exosome SASP, that can be used to identify SASP components or biomarker candidates for senescence burden, aging,
Luigi Ferrucci (150038), Samah Shah (8313159), Vagisha Sharma (708257), Birgit Schilling (31153), Therese Payne (8313153), Anja Holtz (174441), Abhijit Kale (117142), Ok Hee Jeon (8313147), Chirag Rao (8313156), Nathan Basisty (343839), Chisaka Kuehnemann (8313150), Judith Campisi (17061)   +11 more
core   +1 more source

Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells

Nature Communications, 2018
Activation of DNA damage response induces the acquisition of senescence-associated secretory phenotype (SASP) in senescent cells, but precise mechanisms remain unclear.
Akiko Takahashi, Tze Mun Loo, Ryo Okada, Fumitaka Kamachi, Yoshihiro Watanabe, Masahiro Wakita, Sugiko Watanabe, Shimpei Kawamoto, Kenichi Miyata, Glen N. Barber, Naoko Ohtani, Eiji Hara   +11 more
doaj   +1 more source

N-Acetyltransferase 10 Promotes Micronuclei Formation to Activate the Senescence-Associated Secretory Phenotype Machinery in Colorectal Cancer Cells

Translational Oncology, 2020
The formation of micronuclei (MN) is prevalent in human cancer cells and its role in activating the senescence-associated secretory phenotype (SASP) machinery has been identified recently.
Yanan Cao, Mengfei Yao, Yaqian Wu, Ningning Ma, Haijing Liu, Bo Zhang   +5 more
doaj   +1 more source

Senescence-Associated Secretory Phenotype (SASP) in Diabetes

Journal of Pharma Insights and Research
Cellular senescence represents a critical biological process characterized by permanent cell cycle arrest and distinct metabolic alterations. The senescence-associated secretory phenotype (SASP) has emerged as a fundamental mediator linking cellular aging to various pathological conditions, including diabetes mellitus.
null Nandini Mode, null Chaitanya B
openaire   +1 more source

Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP)

Cellular Signalling, 2012
The major hallmark of cellular senescence is an irreversible cell cycle arrest and thus it is a potent tumor suppressor mechanism. Genotoxic insults, e.g. oxidative stress, are important inducers of the senescent phenotype which is characterized by an accumulation of senescence-associated heterochromatic foci (SAHF) and DNA segments with chromatin ...
Salminen, Antero, Kauppinen, Anu, Kaarniranta, Kai   +2 more
openaire   +2 more sources

Cellular senescence and the tumour microenvironment

Molecular Oncology, 2022
The senescence‐associated secretory phenotype (SASP), where senescent cells produce a variety of secreted proteins including inflammatory cytokines, chemokines, matrix remodelling factors, growth factors and so on, plays pivotal but varying roles in the ...
Masaki Takasugi, Yuya Yoshida, Naoko Ohtani   +2 more
doaj   +1 more source

Paracrine Senescence of Mesenchymal Stromal Cells Involves Inflammatory Cytokines and the NF-κB Pathway

Cells, 2022
It has been known that senescence-associated secretory phenotype (SASP) triggers senescence of the surrounding normal cells. However, SASP signaling regarding mesenchymal stromal cell aging remains to be fully elucidated.
Lun-Yin Chou, Chun-Te Ho, Shih-Chieh Hung   +2 more
doaj   +1 more source