Results 51 to 60 of about 8,456,945 (252)

Pleiotropic effects of BAFF on the senescence-associated secretome and growth arrest

eLife, 2023
Senescent cells release a variety of cytokines, proteases, and growth factors collectively known as the senescence-associated secretory phenotype (SASP). Sustained SASP contributes to a pattern of chronic inflammation associated with aging and implicated
Martina Rossi, Carlos Anerillas, Maria Laura Idda, Rachel Munk, Chang Hoon Shin, Stefano Donega, Dimitrios Tsitsipatis, Allison B Herman, Jennifer L Martindale, Xiaoling Yang, Yulan Piao, Krystyna Mazan-Mamczarz, Jinshui Fan, Luigi Ferrucci, Peter F Johnson, Supriyo De, Kotb Abdelmohsen, Myriam Gorospe   +17 more
doaj   +1 more source

TWIST1 controls cellular senescence and energy metabolism in mesenchymal stem cells [PDF]

European Cells & Materials, 2021
Mesenchymal stem cells (MSCs) are promising cells for regenerative medicine therapies because they can differentiate towards multiple cell lineages. However, the occurrence of cellular senescence and the acquiring of the senescence-associated secretory ...
C Voskamp, LA Anderson, WJLM Koevoet, S Barnhoorn, PG Mastroberardino, GJVM van Osch, R Narcisi   +6 more
doaj   +1 more source

Micromanaging fibroblast senescence: The role of small non-coding RNAs in senescence associated secretory phenotype (SASP) [PDF]

, 2015
Introduction: The molecular pathways that dictate the acquisition of senescence-associated secretory phenotype (SASP) by stromal fibroblast during ageing or in response to genotoxic insult have yet to be elucidated.
Kabir, T D
core   +6 more sources

Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells

Nature Communications, 2018
Activation of DNA damage response induces the acquisition of senescence-associated secretory phenotype (SASP) in senescent cells, but precise mechanisms remain unclear.
Akiko Takahashi, Tze Mun Loo, Ryo Okada, Fumitaka Kamachi, Yoshihiro Watanabe, Masahiro Wakita, Sugiko Watanabe, Shimpei Kawamoto, Kenichi Miyata, Glen N. Barber, Naoko Ohtani, Eiji Hara   +11 more
doaj   +1 more source

N-Acetyltransferase 10 Promotes Micronuclei Formation to Activate the Senescence-Associated Secretory Phenotype Machinery in Colorectal Cancer Cells

Translational Oncology, 2020
The formation of micronuclei (MN) is prevalent in human cancer cells and its role in activating the senescence-associated secretory phenotype (SASP) machinery has been identified recently.
Yanan Cao, Mengfei Yao, Yaqian Wu, Ningning Ma, Haijing Liu, Bo Zhang   +5 more
doaj   +1 more source

Cellular senescence and the tumour microenvironment

Molecular Oncology, 2022
The senescence‐associated secretory phenotype (SASP), where senescent cells produce a variety of secreted proteins including inflammatory cytokines, chemokines, matrix remodelling factors, growth factors and so on, plays pivotal but varying roles in the ...
Masaki Takasugi, Yuya Yoshida, Naoko Ohtani   +2 more
doaj   +1 more source

Paracrine Senescence of Mesenchymal Stromal Cells Involves Inflammatory Cytokines and the NF-κB Pathway

Cells, 2022
It has been known that senescence-associated secretory phenotype (SASP) triggers senescence of the surrounding normal cells. However, SASP signaling regarding mesenchymal stromal cell aging remains to be fully elucidated.
Lun-Yin Chou, Chun-Te Ho, Shih-Chieh Hung   +2 more
doaj   +1 more source

Senescence-Associated Secretory Phenotype (SASP) in Diabetes

Journal of Pharma Insights and Research
Cellular senescence represents a critical biological process characterized by permanent cell cycle arrest and distinct metabolic alterations. The senescence-associated secretory phenotype (SASP) has emerged as a fundamental mediator linking cellular aging to various pathological conditions, including diabetes mellitus.
null Nandini Mode, null Chaitanya B
openaire   +1 more source

Targeting the senescence-associated secretory phenotype in cancer therapy

, 2023
The current main strategy in the treatment of cancer is to target rapidly dividing cells, which induces DNA damage and promotes senescence in both cancerous and non-malignant cells alike.
Niamh Kerslake (16845207)
core   +3 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source