Results 51 to 60 of about 10,262,985 (255)

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Targeting SASP with FDA-approved agents: minoxidil and diazoxide as potential senomorphic agents in cancer therapy

Türk Biyokimya Dergisi
Chemotherapy-induced senescent cells are recognized to lead to cancer progression and resistance to treatment by releasing factors associated with the senescence-associated secretory phenotype (SASP).
Simay Demir Yaprak Dilber, Mohammed Ahmed Islam, Tayyar Tugce, Ozdemir Aysun, Ark Mustafa   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Cellular senescence in skin inflammation: molecular mechanisms and potential clinical implications

Frontiers in Aging
Cellular senescence is increasingly regarded as a mechanism linking chronic tissue stress to persistent skin inflammation. Senescent cells are defined by stable cell-cycle arrest with remodeling of morphology, metabolism, and secretory phenotype, of ...
Xinhe Wang, Beibei Xiong, Shuxiao Li, Yi Wang, Fulun Li   +4 more
doaj   +1 more source

The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1

Nature Communications, 2018
In cancer the side effects of therapeutic agents can provoke senescence-associated secretory phenotype (SASP), which can drive cancer resistance. During the DNA damage response, transcription factor Zscan4 expression is elevated by an ATM-TRAF6-TAK1 axis
Boyi Zhang, Da Fu, Qixia Xu, Xianling Cong, Chunyan Wu, Xiaoming Zhong, Yushui Ma, Zhongwei Lv, Fei Chen, Liu Han, Min Qian, Y. Eugene Chin, Eric W. -F. Lam, Paul Chiao, Yu Sun   +14 more
doaj   +1 more source

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype [PDF]

, 2016
Cellular senescence permanently arrests cell proliferation, often accompanied by a multi-faceted senescence-associated secretory phenotype (SASP). Loss of mitochondrial function can drive age-related declines in the function of many post-mitotic tissues,
Campisi, Judith, Liu, Su, Freund, Adam, Lim, Hyung W, Ramanathan, Arvind, Davis, Sonnet S, Gerencser, Akos A, Lecot, Pacome, Velarde, Michael C, Wiley, Christopher D, Verdin, Eric, Sarnoski, Ethan A, Shirakawa, Kotaro   +12 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities [PDF]

, 2013
Contains fulltext : 118113.pdf (Publisher’s version ) (Open Access)Aging is the largest risk factor for most chronic diseases, which account for the majority of morbidity and health care expenditures in developed nations.
Deursen, J.M.A. van, Yi Zhu, Kirkland, J.L., Jan van Deursen, James L. Kirkland, Tchkonia, T., Judith Campisi, Campisi, J., Zhu, Y., Tamara Tchkonia   +9 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration

, 2014
AIM: To develop a model of stress-induced senescence to study the hepatocyte senescence associated secretory phenotype (SASP)
Bokil, NJ, Melino, Michelle, Gabrielli, B, Skoien, Richard, Richard Skoien, Brian Gabrielli, Loo, Dorothy, Michelle Melino, Skoien, R, Elizabeth E Powell, Nilesh J Bokil, Melino, M, Michelle M Hill, Clouston, AD, Hill, Michelle M., Loo, D, Dorothy Loo, Clouston, Andrew D., Sweet, MJ, Hill, MM, Gethin P Thomas, Gabrielli, Brian, Andrew D Clouston, Sweet, Matthew J., Matthew J Sweet, Powell, Elizabeth E., Katharine M Irvine, Powell, EE, Irvine, Katharine M., Irvine, KM, Bokil, Nilesh J., Thomas, Gethin P., Thomas, GP   +32 more
core   +1 more source