Results 51 to 60 of about 17,888 (258)

The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1

Nature Communications, 2018
In cancer the side effects of therapeutic agents can provoke senescence-associated secretory phenotype (SASP), which can drive cancer resistance. During the DNA damage response, transcription factor Zscan4 expression is elevated by an ATM-TRAF6-TAK1 axis
Boyi Zhang, Da Fu, Qixia Xu, Xianling Cong, Chunyan Wu, Xiaoming Zhong, Yushui Ma, Zhongwei Lv, Fei Chen, Liu Han, Min Qian, Y. Eugene Chin, Eric W. -F. Lam, Paul Chiao, Yu Sun   +14 more
doaj   +1 more source

Biliary Epithelial Senescence in Liver Disease: There Will Be SASP

Frontiers in Molecular Biosciences, 2021
Cellular senescence is a pathophysiological phenomenon in which proliferative cells enter cell cycle arrest following DNA damage and other stress signals.
Vik Meadows, Leonardo Baiocchi, Debjyoti Kundu, Keisaku Sato, Yessenia Fuentes, Chaodong Wu, Sanjukta Chakraborty, Shannon Glaser, Gianfranco Alpini, Gianfranco Alpini, Lindsey Kennedy, Lindsey Kennedy, Heather Francis, Heather Francis   +13 more
doaj   +1 more source

Nifuroxazide boosts the anticancer efficacy of palbociclib-induced senescence by dual inhibition of STAT3 and CDK2 in triple-negative breast cancer

Cell Death Discovery, 2023
Though palbociclib, a cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitor has been approved for treating breast cancer, two major clinical challenges remain: (i) Triple-negative breast cancer (TNBC) appears to be more resistant to palbociclib, and (ii ...
Xianzhe Wang, Wei Shi, Xumei Wang, Jin-Jian Lu, Ping He, Hongjie Zhang, Xiuping Chen   +6 more
doaj   +1 more source

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype [PDF]

, 2016
Cellular senescence permanently arrests cell proliferation, often accompanied by a multi-faceted senescence-associated secretory phenotype (SASP). Loss of mitochondrial function can drive age-related declines in the function of many post-mitotic tissues,
Campisi, Judith, Liu, Su, Freund, Adam, Lim, Hyung W, Ramanathan, Arvind, Davis, Sonnet S, Gerencser, Akos A, Lecot, Pacome, Velarde, Michael C, Wiley, Christopher D, Verdin, Eric, Sarnoski, Ethan A, Shirakawa, Kotaro   +12 more
core   +1 more source

Quantitative Proteomic Analysis of the Senescence‐Associated Secretory Phenotype by Data‐Independent Acquisition [PDF]

, 2021
Cellular senescence is a complex stress response that induces an essentially permanent cell cycle arrest and a complex secretory phenotype termed the senescence-associated secretory phenotype (SASP), which drives numerous aging pathologies ...
Francesco Neri, Campisi, Judith, Pierre‐Yves Desprez, Judith Campisi, Birgit Schilling, Schilling, Birgit, Basisty, Nathan, Neri, Francesco, Desprez, Pierre‐Yves, Nathan Basisty   +9 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Targeting SASP with FDA-approved agents: minoxidil and diazoxide as potential senomorphic agents in cancer therapy

Türk Biyokimya Dergisi
Chemotherapy-induced senescent cells are recognized to lead to cancer progression and resistance to treatment by releasing factors associated with the senescence-associated secretory phenotype (SASP).
Simay Demir Yaprak Dilber, Mohammed Ahmed Islam, Tayyar Tugce, Ozdemir Aysun, Ark Mustafa   +4 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Meta-analysis of senescent cell secretomes to identify common and specific features of the different senescent phenotypes: a tool for developing new senotherapeutics

Cell Communication and Signaling, 2023
DNA damage resulting from genotoxic injury can initiate cellular senescence, a state characterized by alterations in cellular metabolism, lysosomal activity, and the secretion of factors collectively known as the senescence-associated secretory phenotype
Yo Oguma, Nicola Alessio, Domenico Aprile, Mari Dezawa, Gianfranco Peluso, Giovanni Di Bernardo, Umberto Galderisi   +6 more
doaj   +1 more source

Senescence-Associated Secretory Phenotype (SASP) in Diabetes

Journal of Pharma Insights and Research
Cellular senescence represents a critical biological process characterized by permanent cell cycle arrest and distinct metabolic alterations. The senescence-associated secretory phenotype (SASP) has emerged as a fundamental mediator linking cellular aging to various pathological conditions, including diabetes mellitus.
null Nandini Mode, null Chaitanya B
openaire   +1 more source