Results 51 to 60 of about 21,370 (250)

Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells

Nature Communications, 2018
Activation of DNA damage response induces the acquisition of senescence-associated secretory phenotype (SASP) in senescent cells, but precise mechanisms remain unclear.
Akiko Takahashi, Tze Mun Loo, Ryo Okada, Fumitaka Kamachi, Yoshihiro Watanabe, Masahiro Wakita, Sugiko Watanabe, Shimpei Kawamoto, Kenichi Miyata, Glen N. Barber, Naoko Ohtani, Eiji Hara   +11 more
doaj   +1 more source

Loss of MECP2 Leads to Activation of P53 and Neuronal Senescence. [PDF]

, 2018
To determine the role for mutations of MECP2 in Rett syndrome, we generated isogenic lines of human induced pluripotent stem cells, neural progenitor cells, and neurons from patient fibroblasts with and without MECP2 expression in an attempt to ...
Allen, Denise, Chronis, Contantinos, Cinkornpumin, Jessica, Fu, Kai, Germanguz, Igal, Korsakova, Elena, Kuoy, Edward, Langerman, Justin, Lee, Peiyee, Lowry, William E, Ohashi, Minori, Park, Jenny C, Pellegrini, Matteo, Plath, Kathrin, Salas, Carlos, Tran, Stephen, Vargas, Benni S, Xiao, Xinshu   +17 more
core   +2 more sources

Biogenesis of Pro-senescent Microparticles by Endothelial Colony Forming Cells from Premature Neonates is driven by SIRT1-Dependent Epigenetic Regulation of MKK6. [PDF]

, 2017
Senescent cells may exert detrimental effect on microenvironment through the secretion of soluble factors and the release of extracellular vesicles, such as microparticles, key actors in ageing and cardiovascular diseases.
Bachelier, R., Chateau, A.L., Dignat-George, F., Lacroix, R., Ligi, I., Louis, L., Magdinier, F., Robert, S., Sabatier, F., Simeoni, U., Simoncini, S., Todorova, D., Yzydorzick, C.   +12 more
core   +3 more sources

Loss of histone macroH2A1 in hepatocellular carcinoma cells promotes paracrine-mediated chemoresistance and CD4+CD25+FoxP3+ regulatory T cells activation [PDF]

, 2020
Rationale: Loss of histone macroH2A1 induces appearance of cancer stem cells (CSCs)-like cells in hepatocellular carcinoma (HCC). How CSCs interact with the tumor microenvironment and the adaptive immune system is unclear. Methods: We screened aggressive
Drovakova A., Giallongo S., Li Volti G., Lo Re O., Mazza T., Rappa F., Roskams T., Sanna P., Tsochatzis E., Van Haele M., Vinciguerra M., Vinh Luong T.   +11 more
core   +1 more source

The role of inflammation in age-related disease. [PDF]

, 2013
The National Institutes of Health (NIH) Geroscience Interest Group (GSIG) sponsored workshop, The Role of Inflammation inAge-Related Disease, was held September 6th-7th, 2012 in Bethesda, MD.
Augustine, Alison Deckhut, Campisi, Judith, Howcroft, T Kevin, Kohanski, Ron, Louis, Germaine Buck, McElhaney, Janet E, Sierra, Felipe, Smith, Martyn T, Wise, Bradley, Wyss-Coray, Tony   +9 more
core   +2 more sources

Biliary Epithelial Senescence in Liver Disease: There Will Be SASP

Frontiers in Molecular Biosciences, 2021
Cellular senescence is a pathophysiological phenomenon in which proliferative cells enter cell cycle arrest following DNA damage and other stress signals.
Vik Meadows, Leonardo Baiocchi, Debjyoti Kundu, Keisaku Sato, Yessenia Fuentes, Chaodong Wu, Sanjukta Chakraborty, Shannon Glaser, Gianfranco Alpini, Gianfranco Alpini, Lindsey Kennedy, Lindsey Kennedy, Heather Francis, Heather Francis   +13 more
doaj   +1 more source

The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1

Nature Communications, 2018
In cancer the side effects of therapeutic agents can provoke senescence-associated secretory phenotype (SASP), which can drive cancer resistance. During the DNA damage response, transcription factor Zscan4 expression is elevated by an ATM-TRAF6-TAK1 axis
Boyi Zhang, Da Fu, Qixia Xu, Xianling Cong, Chunyan Wu, Xiaoming Zhong, Yushui Ma, Zhongwei Lv, Fei Chen, Liu Han, Min Qian, Y. Eugene Chin, Eric W. -F. Lam, Paul Chiao, Yu Sun   +14 more
doaj   +1 more source

Nifuroxazide boosts the anticancer efficacy of palbociclib-induced senescence by dual inhibition of STAT3 and CDK2 in triple-negative breast cancer

Cell Death Discovery, 2023
Though palbociclib, a cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitor has been approved for treating breast cancer, two major clinical challenges remain: (i) Triple-negative breast cancer (TNBC) appears to be more resistant to palbociclib, and (ii ...
Xianzhe Wang, Wei Shi, Xumei Wang, Jin-Jian Lu, Ping He, Hongjie Zhang, Xiuping Chen   +6 more
doaj   +1 more source

The Evolving Role of CD8+CD28- Immunosenescent T Cells in Cancer Immunology [PDF]

, 2019
Functional, tumor-specific CD8+ cytotoxic T lymphocytes drive the adaptive immune response to cancer. Thus, induction of their activity is the ultimate aim of all immunotherapies.
Dey, Mahua, Fetcko, Kaleigh, Henriquez, Mario, Huff, Wei X., Kwon, Jae Hyun   +4 more
core   +1 more source

Mechanisms and therapeutic strategies for senescence-associated secretory phenotype in the intervertebral disc degeneration microenvironment

Journal of Orthopaedic Translation
As a permanent state of cell cycle arrest, cellular senescence has become an important factor in aging and age-related diseases. As a central regulator of physiology and pathology associated with cellular senescence, the senescence associated secretory ...
Yang Liu, Yiming Dou, Xun Sun, Qiang Yang   +3 more
doaj   +1 more source