Results 71 to 80 of about 10,262,985 (255)

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype. [PDF]

, 2015
Senescent cells secrete a combination of factors collectively known as the senescence-associated secretory phenotype (SASP). The SASP reinforces senescence and activates an immune surveillance response, but it can also show pro-tumorigenic properties and
Herranz, Nicolás;Gallage, Suchira;Mellone, Massimiliano;Wuestefeld, Torsten;Klotz, Sabrina;Hanley, Christopher J;Raguz, Selina;Acosta, Juan Carlos;Innes, Andrew J;Banito, Ana;Georgilis, Athena;Montoya, Alex;Wolter, Katharina;Dharmalingam, Gopuraja;Faull, Peter;Carroll, Thomas;Martinez-Barbera, Juan Pedro;Cutillas, Pedro;Reisinger, Florian;Heikenwälder, Mathias;Miller, Richard A;Withers, Dominic;Zender, Lars;Thomas, Gareth J;Gil, Jesus
core   +2 more sources

Effect of menopausal hormone therapy on proteins associated with senescence and inflammation

Physiological Reports, 2020
Background Estrogen may inhibit cell senescence that contributes to age‐related disorders. This study determined the effects of menopausal hormone treatments on circulating levels of markers of cell senescence.
Laura Faubion, Thomas A. White, Brett J. Peterson, Jennifer R. Geske, Nathan K. LeBrasseur, Marissa J. Schafer, Michelle M. Mielke, Virginia M. Miller   +7 more
doaj   +1 more source

Meta-analysis of senescent cell secretomes to identify common and specific features of the different senescent phenotypes: a tool for developing new senotherapeutics

Cell Communication and Signaling, 2023
DNA damage resulting from genotoxic injury can initiate cellular senescence, a state characterized by alterations in cellular metabolism, lysosomal activity, and the secretion of factors collectively known as the senescence-associated secretory phenotype
Yo Oguma, Nicola Alessio, Domenico Aprile, Mari Dezawa, Gianfranco Peluso, Giovanni Di Bernardo, Umberto Galderisi   +6 more
doaj   +1 more source

A Senescence Associated Secretory Phenotype (SASP) in Indolent Systemic Mastocytosis Compared to Healthy Controls [PDF]

Innov Aging
Abstract Indolent systemic mastocytosis (ISM) is a disease characterized by an abnormal proliferation and hyperactivity of neoplastic mast cells in bone marrow and various organ systems, marked by high rates of cognitive dysfunction, musculoskeletal deterioration, and chronic fatigue; clinical manifestations commonly associated with ...
Nicoloro-Santabarbara, Jennifer, Ravindran, Rohan, Giannetti, Matthew, Dwyer, Dan, Lam, Michael, Lee, Pui, Castells, Marianna, Carroll, Judith   +7 more
europepmc   +3 more sources

TGFBI Maintains Fibrocartilage Homeostasis by Restraining O‐GlcNAcylation to Inactivate and Destabilize ADAMTS16 in Temporomandibular Joint Osteoarthritis

Advanced Science, EarlyView.
TGFBI deficiency elevates O‐GlcNAcylation, promoting the transcriptional activation of ADAMTS16 and OGT‐mediated post‐translational modification of ADAMTS16 at Ser1170. This leads to its stabilization and accumulation, driving chondrocyte metabolic disorders and senescent phenotypes, ultimately resulting in fibrocartilage dysfunction and TMJOA ...
Xin Liu, Xinyue Luo, Jie Zhao, Ziyan Jiang, Jiayi Zhai, Taomin Zhu, Xueke Jia, Xiaohan Ma, Henghua Jiang, Huimin Li, Yaping Feng, Jin Ke, Xing Long   +12 more
wiley   +1 more source

The senescence-associated secretory phenotype as a driver of tumor growth: does G3BP1 hold the key?

, 2021
Cellular senescence is a double-edged sword that, depending on the context, acts as either a potent tumor protective mechanism or an age-related driver of diseases such as cancer.
Amr Omer, Imed-Eddine Gallouzi, Sergio Di Marco   +2 more
core   +1 more source

Layer‐Specific Dermal and Subcutaneous Delivery via Modular LNP–Hydrogel‐Integrated Threaded Microneedles

Advanced Science, EarlyView.
Guided by spatial transcriptomics and clinical validation, a threaded microneedle platform enables precise layer‐specific delivery across the dermis and subcutaneous tissue. By addressing distinct pathogenic remodeling in different skin layers, this strategy coordinates compartment‐specific intervention, restores tissue architecture, and offers a ...
Fangzhou Xie, Yixiang Zhang, Shifeng Ling, Yuxuan Huang, Yingying Wei, Rao Fu, Jiahao He, Baikun Liu, Lucia Zhou, Kaifeng Huo, Yida Wang, Qingfeng Li, Yawei Du, Wenguo Cui, Yun Xie   +14 more
wiley   +1 more source

Senescence and the SASP: many therapeutic avenues [PDF]

, 2020
Cellular senescence is a stress response that elicits a permanent cell cycle arrest and triggers profound phenotypic changes such as the production of a bioactive secretome, referred to as the senescence-associated secretory phenotype (SASP).
Birch, J, Gil, Jesus
core   +1 more source

PLXDC2 siRNA‐Mediated Intervention Attenuates Microglial Senescence Through cGAS‐STING Signaling

Advanced Science, EarlyView.
PLXDC2 was identified as a microglial target in Parkinson's disease through human and mouse single‐cell analyses. Ferritin‐armed biomimetic nanovesicles delivered PLXDC2 siRNA, deferoxamine, and CeO2 nanoparticles across the blood–brain barrier, reducing cGAS‐STING activation, iron burden, oxidative stress, and senescence in microglia, thereby ...
Heyue Lu, Zitian Zheng, Feiran Wang, Huanhuan Luo, Fei Ju, Yucheng Zhu, Zheng Zhou, Jie Sun, Zhenghui Qiu, Xiang Luo, Zhongzheng Jia, Jianquan Wang, Hongjie Huang, Bo Zhang   +13 more
wiley   +1 more source

Senescent myoblasts exhibit an altered exometabolome that is linked to senescence-associated secretory phenotype (SASP) signalling [PDF]

Cellular senescence has been implicated in the aging-related dysfunction of satellite cells, the resident muscle stem cell population primarily responsible for the repair of muscle fibers.
Shanmuganathan, Meera, Britz-McKibbin, Philip, Kroezen, Zachery, Joanisse, Sophie, Parise, Gianni, Kamal, Michael   +5 more
core   +1 more source