Results 71 to 80 of about 8,456,945 (252)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Effect of menopausal hormone therapy on proteins associated with senescence and inflammation

Physiological Reports, 2020
Background Estrogen may inhibit cell senescence that contributes to age‐related disorders. This study determined the effects of menopausal hormone treatments on circulating levels of markers of cell senescence.
Laura Faubion, Thomas A. White, Brett J. Peterson, Jennifer R. Geske, Nathan K. LeBrasseur, Marissa J. Schafer, Michelle M. Mielke, Virginia M. Miller   +7 more
doaj   +1 more source

Meta-analysis of senescent cell secretomes to identify common and specific features of the different senescent phenotypes: a tool for developing new senotherapeutics

Cell Communication and Signaling, 2023
DNA damage resulting from genotoxic injury can initiate cellular senescence, a state characterized by alterations in cellular metabolism, lysosomal activity, and the secretion of factors collectively known as the senescence-associated secretory phenotype
Yo Oguma, Nicola Alessio, Domenico Aprile, Mari Dezawa, Gianfranco Peluso, Giovanni Di Bernardo, Umberto Galderisi   +6 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

SASP Modulation for Cellular Rejuvenation and Tissue Homeostasis: Therapeutic Strategies and Molecular Insights

Cells
Cellular senescence regulates aging, tissue maintenance, and disease progression through the Senescence-Associated Secretory Phenotype (SASP), a secretory profile of cytokines, chemokines, growth factors, and matrix-remodeling enzymes.
Saud Alqahtani, Taha Alqahtani, Krishnaraju Venkatesan, Durgaramani Sivadasan, Rehab Ahmed, Nizar Sirag, Hassabelrasoul Elfadil, Hanem Abdullah Mohamed, Haseena T.A., Rasha Elsayed Ahmed, Pooja Muralidharan, Premalatha Paulsamy   +11 more
doaj   +1 more source

Cantharidin induces senescence via inhibition of AMP-activated protein kinase and activation of NLRP3 inflammasome in H9c2 cardiomyocytes

Pakistan Journal of Pharmaceutical Sciences, 2022
Cantharidin is a natural compound with cardiotoxicity. Cellular senescence and senescence-associated secretory phenotype (SASP) are implicated in chemotherapy-associated cardiotoxicity.
Yujing Shi, Yi Lv, Qi You, Weidong Qian
doaj   +1 more source

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities [PDF]

, 2013
Contains fulltext : 118113.pdf (Publisher’s version ) (Open Access)Aging is the largest risk factor for most chronic diseases, which account for the majority of morbidity and health care expenditures in developed nations.
Deursen, J.M.A. van, Yi Zhu, Kirkland, J.L., Jan van Deursen, James L. Kirkland, Tchkonia, T., Judith Campisi, Campisi, J., Zhu, Y., Tamara Tchkonia   +9 more
core   +2 more sources

Matrix Stiffness Induces Endothelial Network Senescence

Advanced Science, EarlyView.
Using a 3D human in vitro model that decouples mechanical stress from inflammatory or biochemical signals, matrix stiffening induces a senescence phenotype in endothelial networks. This mechano‐induced senescence activates Notch signaling, and pharmacologic Notch inhibition attenuates this stiffness‐induced senescence.
Jiyeon Song, Alexandra N. Rindone, Ya Guan, Connor D. Amelung, Prarthana Sanjay Daswani, Jennifer H. Elisseeff, Sharon Gerecht   +6 more
wiley   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

COPD-derived fibroblasts secrete higher levels of senescence-associated secretory phenotype proteins. [PDF]

, 2020
COPD-derived fibroblasts have increased cellular senescence. Senescent cell accumulation can induce tissue dysfunction by their senescence-associated secretory phenotype (SASP).
Heijink IH, de Vries M, Woldhuis RR, Oliver BGG, van den Berge M, Timens W, Brandsma C-A   +6 more
core   +4 more sources