Results 61 to 70 of about 17,888 (258)

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities [PDF]

, 2013
Contains fulltext : 118113.pdf (Publisher’s version ) (Open Access)Aging is the largest risk factor for most chronic diseases, which account for the majority of morbidity and health care expenditures in developed nations.
Deursen, J.M.A. van, Yi Zhu, Kirkland, J.L., Jan van Deursen, James L. Kirkland, Tchkonia, T., Judith Campisi, Campisi, J., Zhu, Y., Tamara Tchkonia   +9 more
core   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype. [PDF]

, 2015
Senescent cells secrete a combination of factors collectively known as the senescence-associated secretory phenotype (SASP). The SASP reinforces senescence and activates an immune surveillance response, but it can also show pro-tumorigenic properties and
Herranz, Nicolás;Gallage, Suchira;Mellone, Massimiliano;Wuestefeld, Torsten;Klotz, Sabrina;Hanley, Christopher J;Raguz, Selina;Acosta, Juan Carlos;Innes, Andrew J;Banito, Ana;Georgilis, Athena;Montoya, Alex;Wolter, Katharina;Dharmalingam, Gopuraja;Faull, Peter;Carroll, Thomas;Martinez-Barbera, Juan Pedro;Cutillas, Pedro;Reisinger, Florian;Heikenwälder, Mathias;Miller, Richard A;Withers, Dominic;Zender, Lars;Thomas, Gareth J;Gil, Jesus
core   +2 more sources

NLRP1 inflammasome promotes senescence and senescence-associated secretory phenotype [PDF]

International audienceAbstract Background Senescence is a cellular aging-related process triggered by different stresses and characterized by the secretion of various inflammatory factors referred to as senescence-associated secretory phenotype (SASP ...
Gallardo-Orihuela, Andrea, Mbalaviele, Gabriel, Couillin, Isabelle, Ryffel, Bernhard, von Zglinicki, Thomas, Muela-Zarzuela, Inés, Wang, Chun, Kitaura, Jiro, Suarez-Rivero, Juan Miguel, Cordero, Mario D., Cordero, Mario, Sanz, Alberto, Izawa, Kumi, de Gregorio-Procopio, Marta, Cordero, Mario D   +14 more
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Cellular senescence in cancer immunology and potential therapeutic strategy

Frontiers in Oncology
Cellular senescence represents a state of stable, often irreversible cell cycle arrest. Unlike apoptosis, senescent cells (SCs) remain metabolically active and engage in robust secretory activity, most notably through the senescence-associated secretory ...
Xiao-Dan Qian, Li-De Tao, Li-Hong Zhang, An-Lai Ji, Lei Wang, Muhammad Mudasar Iqbal, Yi Luo   +6 more
doaj   +1 more source

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, EarlyView.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source

Effect of menopausal hormone therapy on proteins associated with senescence and inflammation

Physiological Reports, 2020
Background Estrogen may inhibit cell senescence that contributes to age‐related disorders. This study determined the effects of menopausal hormone treatments on circulating levels of markers of cell senescence.
Laura Faubion, Thomas A. White, Brett J. Peterson, Jennifer R. Geske, Nathan K. LeBrasseur, Marissa J. Schafer, Michelle M. Mielke, Virginia M. Miller   +7 more
doaj   +1 more source

Potential role of senescent macrophages in radiation-induced pulmonary fibrosis

Cell Death and Disease, 2021
Radiation-induced pulmonary fibrosis (RIPF) is a late toxicity of therapeutic radiation in clinic with poor prognosis and limited therapeutic options. Previous results have shown that senescent cells, such as fibroblast and type II airway epithelial cell,
Lulu Su, Yinping Dong, Yueying Wang, Yuquan Wang, Bowen Guan, Yanhua Lu, Jing Wu, Xiaochun Wang, Deguan Li, Aimin Meng, Feiyue Fan   +10 more
doaj   +1 more source

Senescence and the SASP: many therapeutic avenues [PDF]

, 2020
Cellular senescence is a stress response that elicits a permanent cell cycle arrest and triggers profound phenotypic changes such as the production of a bioactive secretome, referred to as the senescence-associated secretory phenotype (SASP).
Birch, J, Gil, Jesus
core   +1 more source