Results 61 to 70 of about 8,456,945 (252)

Targeting SASP with FDA-approved agents: minoxidil and diazoxide as potential senomorphic agents in cancer therapy

Türk Biyokimya Dergisi
Chemotherapy-induced senescent cells are recognized to lead to cancer progression and resistance to treatment by releasing factors associated with the senescence-associated secretory phenotype (SASP).
Simay Demir Yaprak Dilber, Mohammed Ahmed Islam, Tayyar Tugce, Ozdemir Aysun, Ark Mustafa   +4 more
doaj   +1 more source

The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1

Nature Communications, 2018
In cancer the side effects of therapeutic agents can provoke senescence-associated secretory phenotype (SASP), which can drive cancer resistance. During the DNA damage response, transcription factor Zscan4 expression is elevated by an ATM-TRAF6-TAK1 axis
Boyi Zhang, Da Fu, Qixia Xu, Xianling Cong, Chunyan Wu, Xiaoming Zhong, Yushui Ma, Zhongwei Lv, Fei Chen, Liu Han, Min Qian, Y. Eugene Chin, Eric W. -F. Lam, Paul Chiao, Yu Sun   +14 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Nifuroxazide boosts the anticancer efficacy of palbociclib-induced senescence by dual inhibition of STAT3 and CDK2 in triple-negative breast cancer

Cell Death Discovery, 2023
Though palbociclib, a cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitor has been approved for treating breast cancer, two major clinical challenges remain: (i) Triple-negative breast cancer (TNBC) appears to be more resistant to palbociclib, and (ii ...
Xianzhe Wang, Wei Shi, Xumei Wang, Jin-Jian Lu, Ping He, Hongjie Zhang, Xiuping Chen   +6 more
doaj   +1 more source

Biliary Epithelial Senescence in Liver Disease: There Will Be SASP

Frontiers in Molecular Biosciences, 2021
Cellular senescence is a pathophysiological phenomenon in which proliferative cells enter cell cycle arrest following DNA damage and other stress signals.
Vik Meadows, Leonardo Baiocchi, Debjyoti Kundu, Keisaku Sato, Yessenia Fuentes, Chaodong Wu, Sanjukta Chakraborty, Shannon Glaser, Gianfranco Alpini, Gianfranco Alpini, Lindsey Kennedy, Lindsey Kennedy, Heather Francis, Heather Francis   +13 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Cellular senescence in cancer immunology and potential therapeutic strategy

Frontiers in Oncology
Cellular senescence represents a state of stable, often irreversible cell cycle arrest. Unlike apoptosis, senescent cells (SCs) remain metabolically active and engage in robust secretory activity, most notably through the senescence-associated secretory ...
Xiao-Dan Qian, Li-De Tao, Li-Hong Zhang, An-Lai Ji, Lei Wang, Muhammad Mudasar Iqbal, Yi Luo   +6 more
doaj   +1 more source

Senescent myoblasts exhibit an altered exometabolome that is linked to senescence-associated secretory phenotype (SASP) signalling [PDF]

Cellular senescence has been implicated in the aging-related dysfunction of satellite cells, the resident muscle stem cell population primarily responsible for the repair of muscle fibers.
Shanmuganathan, Meera, Britz-McKibbin, Philip, Kroezen, Zachery, Joanisse, Sophie, Parise, Gianni, Kamal, Michael   +5 more
core   +1 more source

MLL1 is essential for the senescence-associated secretory phenotype [PDF]

, 2016
Oncogene-induced senescence (OIS) and therapy-induced senescence (TIS), while tumor-suppressive, also promote procarcinogenic effects by activating the DNA damage response (DDR), which in turn induces inflammation.
Shah, Parisha P., Capell, Brian C., Adams, Peter D., Simola, Daniel F., Natale, Christopher, Rai, Taranjit, Zhu, Jiajun, Donahue, Greg, Ridky, Todd W., Berger, Shelley L., Dou, Zhixun, Rai, Taranjit Singh, Dorsey, Jean, Drake, Adam M., Sammons, Morgan   +14 more
core   +1 more source