Local senolysis in aged mice only partially replicates the benefits of systemic senolysis
Journal of Clinical Investigation, 2023 Clearance of senescent cells (SnCs) can prevent several age-related pathologies, including bone loss. However, the local versus systemic roles of SnCs in mediating tissue dysfunction remain unclear.
Joshua N Farr +2 more
exaly +4 more sources
Dual‐Target ROS‐Driven Spatiotemporal Senolysis for Vascular Repair and Immune Microenvironment Reprogramming in the Treatment of Ocular Fundus Neovascularization [PDF]
Advanced ScienceOcular fundus neovascularization (OFN) is a leading cause of irreversible vision loss. Conventional antivascular endothelial growth factor (anti‐VEGF) therapies indiscriminately suppress pathological and reparative angiogenesis and fail to correct the ...
Yali Zhou +10 more
doaj +3 more sources
Senescence-Associated Molecules and Tumor-Immune-Interactions as Prognostic Biomarkers in Colorectal Cancer [PDF]
Frontiers in Medicine, 2022 Background and AimsThe initiation of cellular senescence in response to protumorigenic stimuli counteracts malignant progression in (pre)malignant cells.
Franziska Kellers +8 more
doaj +3 more sources
Healthy aging—would cytotoxic T lymphocytes stand out? [PDF]
Cell Death Discovery, 2023 Senescent cells (SnCs) accumulate in multiple tissue types with the process of individual aging, hindering tissue renewal and driving multiple aging-related disorders.
Tianyu Zhang, Jinjin Zhang, Shixuan Wang
doaj +2 more sources
Aging and cancer hallmarks as therapeutic targets [PDF]
Acta Materia Medica, 2023 The prevalence of age-related diseases has been progressively increasing worldwide. The pathogenesis of these disorders, including cancer, is closely associated with an age-dependent decline in cellular functions.
Jingchao Wang +2 more
doaj +3 more sources
Deconstructing cellular senescence in bone and beyond [PDF]
The Journal of Clinical Investigation, 2023 Osteocytes are specialized bone cells that orchestrate skeletal remodeling. Senescent osteocytes are characterized by an activation of cyclin-dependent kinase inhibitor p16Ink4a and have been implicated in the pathogenesis of several bone loss disorders.
Lorenz C. Hofbauer +2 more
doaj +2 more sources
Generation of a selective senolytic platform using a micelle-encapsulated Sudan Black B conjugated analog. [PDF]
Nat AgingThe emerging field of senolytics is centered on eliminating senescent cells to block their contribution to the progression of age-related diseases, including cancer, and to facilitate healthy aging.
Magkouta S +22 more
europepmc +4 more sources
Benzyl isothiocyanate provokes senolysis by targeting AKT in senescent IPF fibroblasts and reverses persistent pulmonary fibrosis in aged mice [PDF]
Frontiers in PharmacologyIntroductionSenescent cells (SCs) accumulate with age and play a causative role in age-related diseases, such as idiopathic pulmonary fibrosis (IPF). Clearance of SCs attenuates lung fibrogenesis and favors fibrosis resolution, suggesting that targeting ...
Rui Wang +9 more
doaj +2 more sources
The Senolytic Drug Navitoclax Protects the Brain After Experimental Ischemic Stroke [PDF]
PharmaceuticalsBackground/Objectives: Senescence has been recently described in brain cells following ischemic stroke. The potential of targeting senescence as an effective therapeutic approach in the treatment of ischemic stroke requires further investigation.
Dianoush Falahatgaroshibi +6 more
doaj +2 more sources
Cyclophilin D plays a critical role in the survival of senescent cells [PDF]
The EMBO JournalSenescent cells play a causative role in many diseases, and their elimination is a promising therapeutic strategy. Here, through a genome-wide CRISPR/Cas9 screen, we identify the gene PPIF, encoding the mitochondrial protein cyclophilin D (CypD), as a ...
Margherita Protasoni +9 more
doaj +2 more sources