Results 41 to 50 of about 1,495 (185)

Genetic screens identify novel liabilities of senescent cells [PDF]

, 2021
Drugs that selectively kill senescent cells, senolytics, can improve the outcomes of cancer, fibrosis and age-related diseases. Despite their potential, our knowledge of the molecular pathways that affect the survival of senescent cells is limited.
McHugh, Domhnall Seamus
core   +1 more source

Decreased Glucose Metabolism and Declined Chaperones Are Unique Features Required for the Survival of Senescent Fibroblasts and Pyruvate Dehydrogenase Is a Potent Senolytic Target. [PDF]

Aging Cell
By a global proteomic profiling of senescent human BJ fibroblasts induced by ionizing radiation, key cellular features required for the survival of senescent fibroblasts were revealed, and pyruvate dehydrogenase was demonstrated as a potent senolytic target for selectively eliminating senescent normal cells, particularly the therapy‐induced senescent ...
Zhang M, Hu Z, Piao S, Song Y, Jia Y, Liu J, Zhao N, Liu A, Fu S, Sun W, Xu H, Yang Y, Gygi SP, Zhou C.   +13 more
europepmc   +2 more sources

Glutaminase-1 inhibition alleviates senescence of Wharton’s jelly-derived mesenchymal stem cells via senolysis [PDF]

Stem Cells Translational Medicine
Sang Eon Park, Suk-Joo Choi, Sun Jeog Kim   +2 more
exaly   +2 more sources

A superoxide-driven redox state promotes geroconversion and resistance to senolysis in replication-stress associated senescence

Redox Biology, 2023
Using S-phase synchronized RPE1-hTERT cells exposed to the DNA damaging agent, methyl methanesulfonate, we show the existence of a redox state associated with replication stress-induced senescence termed senescence-associated redox state (SA-redox state).
Le Luo, Shazib Pervaiz, Marie-Veronique Clement   +2 more
doaj   +1 more source

Context-dependent roles of cellular senescence in normal, aged, and disease states. [PDF]

, 2023
Cellular senescence is a state of irreversible cell cycle arrest that often emerges after tissue damage and in age-related diseases. Through the production of a multicomponent secretory phenotype (SASP), senescent cells can impact the regeneration and ...
Cisneros, Andrés, Cobos, Aina Calls, Moiseeva, Victoria, Muñoz-Cánoves, Pura, Oñate, Claudia Santos, Perdiguero, Eusebio, Serrano, Antonio L, Tarrega, Aida Beà   +7 more
core   +1 more source

High-Throughput Functional Genetic and Compound Screens Identify Targets for Senescence Induction in Cancer

Cell Reports, 2017
Senescence is a proliferation arrest that can result from a variety of stresses. Cancer cells can also undergo senescence, but the stresses that provoke cancer cells to undergo senescence are unclear.
Liqin Wang, Rodrigo Leite de Oliveira, Cun Wang, João M. Fernandes Neto, Sara Mainardi, Bastiaan Evers, Cor Lieftink, Ben Morris, Fleur Jochems, Lisa Willemsen, Roderick L. Beijersbergen, René Bernards   +11 more
doaj   +1 more source

The roles and mechanisms of senescence-associated secretory phenotype (SASP): can it be controlled by senolysis?

Inflammation and Regeneration, 2022
Cellular senescence is a state of irreversible cell cycle arrest that can be induced by a variety of potentially oncogenic stimuli, including DNA damage.
Naoko Ohtani
doaj   +1 more source

Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium [PDF]

, 2017
In cycling human endometrium, menstruation is followed by rapid estrogen-dependent growth. Upon ovulation, progesterone and rising cellular cAMP levels activate the transcription factor Forkhead box O1 (FOXO1) in endometrial stromal cells (EnSCs ...
Acosta, Aird, Al-Sabbagh, Barros, Bradford, Childs, Chowdhury, de Keizer, de Ziegler, Demidenko, Diep, Dimri, Drury, Erlebacher, Evans, Funayama, Gellersen, Groll, Hanna, Hapangama, Iannello, Krizhanovsky, Laws, Lucas, Lucas, Marçais, Matjusaitis, Mosteiro, Murakami, Muñoz-Espín, Paria, Park, Pfaffl, Pohnke, Rajagopalan, Ritschka, Ruifrok, Sadaie, Saeed, Sagiv, Sagiv, Salker, Smith, Takano, Team, van Deursen, Venables, Xiong, Yuan, Zhang, Zhu, Zhu   +51 more
core   +2 more sources

Sorafenib, Rapamycin, and Venetoclax Attenuate Doxorubicin-Induced Senescence and Promote Apoptosis in HCT116 Cells [PDF]

, 2021
Emerging evidence has shown that the therapy-induced senescent growth arrest in cancer cells is of durable nature whereby a subset of cells can reinstate proliferative capacity.
Alhazzani, Khalid, Alhoshani, Ali R., Almutairi, Mashal M., Alohaydib, Munirah, Alotiabi, Moureq R., As Sobeai, Homood M., Gewirtz, David A., Saleh, Tareq   +7 more
core   +2 more sources

Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy

Frontiers in Oncology, 2018
In addition to promoting various forms of cell death, most conventional anti-tumor therapies also promote senescence. There is now extensive evidence that therapy-induced senescence (TIS) might be transient, raising the concern that TIS could represent ...
Tareq Saleh, Tareq Saleh, Liliya Tyutynuk-Massey, Liliya Tyutynuk-Massey, Emmanuel K. Cudjoe, Michael O. Idowu, Joseph W. Landry, Joseph W. Landry, David A. Gewirtz, David A. Gewirtz   +9 more
doaj   +1 more source