Results 31 to 40 of about 1,495 (185)
Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. [PDF]
, 2020 The accumulation of senescent cells (SnCs) is a causal factor of various age-related diseases as well as some of the side effects of chemotherapy. Pharmacological elimination of SnCs (senolysis) has the potential to be developed into novel therapeutic ...
Budamagunta, Vivekananda +9 more
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The Emergence of Senescent Surface Biomarkers as Senotherapeutic Targets
Cells, 2021 Senescence is linked to a wide range of age-associated diseases and physiological declines. Thus, senotherapeutics are emerging to suppress the detrimental effects of senescence either by senomorphics or senolytics.
Martina Rossi, Kotb Abdelmohsen
doaj +1 more source
The emerging role of cellular senescence in renal diseases [PDF]
, 2020 Cellular senescence represents the state of irreversible cell cycle arrest during cell division. Cellular senescence not only plays a role in diverse biological events such as embryogenesis, tissue regeneration and repair, ageing and tumour occurrence ...
Alpini, Gianfranco +12 more
core +1 more source
Dietary restriction in senolysis and prevention and treatment of disease
Critical Reviews in Food Science and Nutrition, 2022 Aging represents a key risk factor for a plethora of diseases. Targeting detrimental processes which occur during aging, especially before onset of age-related disease, could provide drastic improvements in healthspan. There is increasing evidence that dietary restriction (DR), including caloric restriction, fasting, or fasting-mimicking diets, extend ...
Sepideh Aminzadeh-Gohari +2 more
openaire +3 more sources
Preclinical evaluation of senescence-based strategies to improve cancer therapy [PDF]
, 2022 [ES] Esta tesis doctoral titulada "Evaluación preclínica de estrategias basadas en la senescencia para mejorar la terapia contra el cáncer" se centra en explotar la senescencia como opción terapéutica en los tratamientos contra el cáncer mediante el ...
Estepa Fernández, Alejandra
core +1 more source
Preclinical antitumor efficacy of senescence-inducing chemotherapy combined with a nanoSenolytic [PDF]
, 2020 [EN] The induction of senescence produces a stable cell cycle arrest in cancer cells, thereby inhibiting tumor growth; however, the incomplete immune cell-mediated clearance of senescent cells may favor tumor relapse, limiting the long-term anti ...
Alfonso-Navarro, María +8 more
core +1 more source
p19Arf Exacerbates Cigarette Smoke-Induced Pulmonary Dysfunction
Biomolecules, 2020 Senescent cells accumulate in tissues during aging or pathological settings. The semi-genetic or pharmacological targeting of senescent cells revealed that cellular senescence underlies many aspects of the aging-associated phenotype and diseases.
Ryuta Mikawa +5 more
doaj +1 more source
Cellular Senescence in Arterial Diseases
Journal of Lipid and Atherosclerosis, 2020 Cell-proliferation potency is limited, as cells cannot proceed through the cell cycle continually. Instead, they eventually show an irreversible arrest of proliferation, commonly referred to as cellular senescence. Following the initial discovery of this
Ippei Shimizu, Tohru Minamino
doaj +1 more source
Senescence under appraisal: hopes and challenges revisited. [PDF]
, 2021 In recent years, cellular senescence has become the focus of attention in multiple areas of biomedical research. Typically defined as an irreversible cell cycle arrest accompanied by increased cellular growth, metabolic activity and by a characteristic ...
Davan-Wetton, CSA +3 more
core +1 more source
Cellular senescence and the tumour microenvironment
Molecular Oncology, 2022 The senescence‐associated secretory phenotype (SASP), where senescent cells produce a variety of secreted proteins including inflammatory cytokines, chemokines, matrix remodelling factors, growth factors and so on, plays pivotal but varying roles in the ...
Masaki Takasugi +2 more
doaj +1 more source