Results 21 to 30 of about 1,495 (185)

Cytotoxic and senescence-inducing effects of BLU554 in pancreatic ductal adenocarcinoma: an in vitro study [PDF]

BMC Cancer
Background Fibroblast growth factor receptor 4 (FGFR4) is overexpressed in up to 50% of pancreatic ductal adenocarcinoma (PDAC) cases. BLU9931, a selective FGFR4 inhibitor, exerts cytotoxic effects on PDAC cells and induces cellular senescence.
Masakazu Fujiwara, Seiichi Shinji, Yuuki Shichi, Keisuke Nonaka, Yasuko Hasegawa, Kimimasa Takahashi, Hirofumi Rokutan, Tomio Arai, Toshiyuki Ishiwata   +8 more
doaj   +2 more sources

Senescence‐Inducing Therapy Sequential NIR‐II Mild Photothermal/Senolytic Therapy of Triple Negative Breast Cancer

Advanced Science
Targeting the limited therapeutic options and frequent drug resistance in triple negative breast cancer (TNBC) remains a critical clinical challenge.
Liya Yu, Yehui Kang, Mengdie Yu, Yuejia Ding, Yang Chen, Qingyuan Wu, Yu Cai, Huiyu Liu, Zhenye Lv   +8 more
doaj   +2 more sources

HPV-Negative Oral Squamous Cell Carcinoma Arising from Oral Submucous Fibrosis with p16INK4A Positivity and Cellular Senescence: A Case Report. [PDF]

J Clin Exp Dent
Oral Submucous Fibrosis (OSF) is a chronic, progressive, and potentially malignant disorder primarily associated with areca nut chewing. While Oral Squamous Cell Carcinoma (OSCC) typically develops in the tongue and floor of the mouth, its occurrence in ...
Chaurasia A, Pantelis P, Theocharous G, Veroutis D, Kotsinas A, Gorgouli EV, Georgakopoulou E.   +6 more
europepmc   +3 more sources

Efficacy and limitations of senolysis in atherosclerosis [PDF]

Cardiovascular Research, 2021
Abstract Aims Traditional markers of cell senescence including p16, Lamin B1, and senescence-associated beta galactosidase (SAβG) suggest very high frequencies of senescent cells in atherosclerosis, while their removal via ‘senolysis’ has been reported to reduce atherogenesis.
Garrido, Abel Martin, Kaistha, Anuradha, Uryga, Anna K, Oc, Sebnem, Foote, Kirsty, Shah, Aarti, Finigan, Alison, Figg, Nichola, Dobnikar, Lina, Jørgensen, Helle, Bennett, Martin   +10 more
openaire   +2 more sources

Therapeutic opportunities for senolysis in cardiovascular disease [PDF]

The FEBS Journal, 2022
Cellular senescence within the cardiovascular system has, until recently, been understudied and unappreciated as a factor in the development of age‐related cardiovascular diseases such as heart failure, myocardial infarction and atherosclerosis. This is in part due to challenges with defining senescence within post‐mitotic cells such as cardiomyocytes.
Mark Sweeney, Stuart A. Cook, Jesús Gil
openaire   +4 more sources

Combined inhibition of class 1-PI3K-alpha and delta isoforms causes senolysis by inducing p21WAF1/CIP1 proteasomal degradation in senescent cells [PDF]

Cell Death and Disease
The targeted elimination of radio- or chemotherapy-induced senescent cells by so-called senolytic substances represents a promising approach to reduce tumor relapse as well as therapeutic side effects such as fibrosis.
Judith Neuwahl, Chantal A. Neumann, Annika C. Fitz, Anica D. Biermann, Maja Magel, Annabelle Friedrich, Lorenz Sellin, Björn Stork, Roland P. Piekorz, Peter Proksch, Wilfried Budach, Reiner U. Jänicke, Dennis Sohn   +12 more
doaj   +2 more sources

Cellular Senescence, Inflammaging and Cardiovascular Disease. [PDF]

Immunol Rev
ABSTRACT Aging is the most important yet unmodifiable risk factor for cardiovascular disease (CVD). As a result, targeting cardiovascular aging has emerged as a promising strategy to promote long‐term cardiovascular health. This review summarizes current knowledge on the effects of aging within the cardiovascular system as well as systemic processes ...
Zanders L, Arifaj D, Wagner JUG, Dimmeler S.   +3 more
europepmc   +2 more sources

Therapeutic Senolysis of Axitinib-Induced Senescent Human Lung Cancer Cells. [PDF]

Cancers (Basel)
Background: Tyrosine kinase inhibitors (TKIs) inhibit receptor-mediated signals in cells. Axitinib is a TKI with high specificity for vascular endothelial growth factor receptors (VEGFRs). Aim: We determined whether axitinib could induce senescence in human cancer cells and be lysed by the senolytic drug ABT-263.
Kotani H, Han W, Iida Y, Tanino R, Katakawa K, Okimoto T, Tsubata Y, Isobe T, Harada M.   +8 more
europepmc   +3 more sources

Death-seq identifies regulators of cell death and senolytic therapies. [PDF]

, 2023
Selectively ablating damaged cells is an evolving therapeutic approach for age-related disease. Current methods for genome-wide screens to identify genes whose deletion might promote the death of damaged or senescent cells are generally underpowered ...
Bassik, Michael, Colville, Alex, Dixon, Scott, Goshayeshi, Armon, Ishak, Heather, Klein, Julian, Lai, Celine, Liu, Chun, Liu, Jie-Yu, Morgens, David, Rando, Thomas, Rhee, June-Wha, Rodriguez-Mateo, Cristina, Salvi, Jayesh, Spees, Kaitlyn, Thomas, Samantha, Wu, Joseph, Yao, David, Zhou, Ronghao   +18 more
core   +1 more source

Combination of palbociclib with navitoclax based-therapies enhances in vivo antitumoral activity in triple-negative breast cancer [PDF]

, 2023
[EN] Triple-negative breast cancer (TNBC) is a very aggressive subtype of breast cancer with a poor prognosis and limited effective therapeutic options.
Blandez, Juan F., Estepa-Fernández, Alejandra, Galiana, Irene, García-Fernández, Alba, Lerida-Viso, Araceli, Martínez-Máñez, Ramón, Orzaez, Mar, Sancenón Galarza, Félix   +7 more
core   +1 more source