Senolysis of gemcitabine‐induced senescent human pancreatic cancer cells [PDF]
Cancer ReportsIntroduction Gemcitabine (GEM) is often used to treat pancreatic cancer. Many anti‐cancer drugs induce cancer cell death, but some cells survive after cell cycle arrest. Such a response to DNA damage is termed cellular senescence.
Mohammad Mahbubul Hoque +3 more
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Inhibition of glutaminase elicits senolysis in therapy-induced senescent melanoma cells [PDF]
Cell Death and DiseaseThe cyclin D1-Cyclin-Dependent Kinases 4 and 6 (CDK4/6) complex is crucial for the development of melanoma. We previously demonstrated that targeting CDK4/6 using small molecule inhibitors (CDK4/6i) suppresses BrafV600E melanoma growth in vitro and in ...
Justin Kim +5 more
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Senolysis potentiates endothelial progenitor cell adhesion to and integration into the brain vasculature [PDF]
Stem Cell Research & TherapyBackground One of the most severe consequences of ageing is cognitive decline, which is associated with dysfunction of the brain microvasculature. Thus, repairing the brain vasculature could result in healthier brain function.
Tri Duc Lam +6 more
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A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells [PDF]
Nature Communications, 2020 Senescent cells can influence the tumour microenvironment by secreting immunomodulatory factors and are thus a therapeutic target. Here, the authors identify a compound that degrades BET leading to DNA damage and activation of autophagy and a reduction ...
Akiko Takahashi +2 more
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Photoactivatable senolysis with single-cell resolution delays aging [PDF]
Nature Aging, 2023 Strategies that can selectively eliminate senescent cells (SnCs), namely senolytics, have been shown to promote healthy lifespan. However, it is challenging to achieve precise, broad-spectrum and tractable senolysis.
Gao, Ying +8 more
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Senescence and senolysis in cancer: The latest findings [PDF]
Cancer ScienceAbstractAging is a life phenomenon that occurs in most living organisms and is a major risk factor for many diseases, including cancer. Cellular senescence is a cellular trait induced by various genomic and epigenetic stresses. Senescent cells are characterized by irreversible cell growth arrest and excessive secretion of inflammatory cytokines ...
Makoto Nakanishi, Yoshimi Imawari
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Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell types [PDF]
iScience, 2022 Summary: Cellular senescence is a driver of many age-related pathologies. There is an active search for pharmaceuticals termed senolytics that can mitigate or remove senescent cells in vivo by targeting genes that promote the survival of senescent cells.
Chandani Limbad +9 more
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Senolysis by GLS1 Inhibition Ameliorates Kidney Aging by Inducing Excessive mPTP Opening Through MFN1 [PDF]
Journals of Gerontology - Series A Biological Sciences and Medical SciencesAbstract Cellular senescence is a pivotal contributor to aging and age-related diseases. The targeted elimination of senescent cells, known as senolysis, has emerged as a promising therapeutic strategy for mitigating these conditions.
Yuting Chen
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Pharmacological Research, 2022 Many anticancer agents used in clinics induce premature senescence in healthy tissues generating accelerated aging processes and adverse side-effects in patients.
Araceli Lérida-Viso +10 more
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Abrogation of aberrant glycolytic interactions eliminates senescent cells and alleviates aging-related dysfunctions [PDF]
Signal Transduction and Targeted TherapyCellular senescence is deeply involved in physiological homeostasis, development, tissue repair, aging, and diseases. Senescent cells (SnCs) accumulate in aged tissues and exert deleterious effects by secreting proinflammatory molecules that contribute ...
Takumi Mikawa +27 more
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