Results 51 to 60 of about 1,495 (185)

Targeting chemoresistant senescent pancreatic cancer cells improves conventional treatment efficacy

Molecular Biomedicine, 2023
Pancreatic cancer is one of the deadliest cancers owing to its late diagnosis and of the strong resistance to available treatments. Despite a better understanding of the disease in the last two decades, no significant improvement in patient care has been
Sara Jaber, Marine Warnier, Christopher Leers, Mathieu Vernier, Delphine Goehrig, Jean-Jacques Médard, David Vindrieux, Dorian V. Ziegler, David Bernard   +8 more
doaj   +1 more source

Prognostic Implications of Cellular Senescence in Acute Myeloid Leukemia [PDF]

, 2022
Acute myeloid leukemia (AML) is a heterogeneous disease for which biologically grounded predictors of outcome remain a clinical need. In addition to tumor cell death, antineoplastic drugs can mediate a long-lasting growth arrest of vital, metabolically ...
Schönlein, Martin
core   +1 more source

Targeting senescent cell clearance: An approach to delay aging and age-associated disorders

Translational Medicine of Aging, 2021
Cellular senescence is the occurrence of irreversible cell cycle arrest resulting from accumulated DNA damage and the loss of proteostasis over time. Senescent cells contribute to age-related diseases and aging itself. Therefore, the targeted elimination
Zhengqi Qiu, Jiali Jia, Haoman Zou, Ying Ao, Baohua Liu, Zimei Wang   +5 more
doaj   +1 more source

Senolytic Treatment Reduces Acute and Chronic Lung Inflammation in an Aged Mouse Model of Influenza. [PDF]

Aging Cell
Removing age‐related senescent cells before influenza infection in aged mice did not reduce viral replication but lessened lung pathology and gut dysbiosis, which contribute to disease severity. Treatment also mitigated long sequelae in lungs. Effects were mostly age‐dependent, implicating pre‐existing senescent cells in disease severity.
Delval L, Creskey M, Valentin C, Bordas C, Raviola S, Lipskaia L, Heumel S, Deruyter L, Sencio V, Wolowczuk I, Bernard D, Adnot S, Gosset P, Zhang X, Trottein F.   +14 more
europepmc   +2 more sources

Oxidative stress-induced cellular senescence in aging retina and age-related macular degeneration [PDF]

, 2022
Aging leads to a gradual decline of function in multiple organs. Cataract, glaucoma, diabetic retinopathy, and age-related macular degeneration (AMD) are age-related ocular diseases.
Ahmed, Tazbir, Suzumura, Ayana, Terao, Ryo, Terasaki, Hiroko   +3 more
core   +2 more sources

Vascular Senescence in Cardiovascular and Metabolic Diseases

Frontiers in Cardiovascular Medicine, 2018
In mammals, aging is associated with accumulation of senescent cells. Stresses such as telomere shortening and reactive oxygen species induce “cellular senescence”, which is characterized by growth arrest and alteration of the gene expression profile ...
Goro Katsuumi, Ippei Shimizu, Ippei Shimizu, Yohko Yoshida, Yohko Yoshida, Tohru Minamino   +5 more
doaj   +1 more source

Editorial: New insights into adult neurogenesis and neurodegeneration: challenges for brain repair [PDF]

, 2022
The formation of new neurons in the brain is probably one of the most controversial topics in the scientific community since in the 1960's Joseph Altman described for the first time that proliferating cells give rise to new neurons in the adult brain of ...
Herranz Pérez, Vicente, Kaneko, Naoko, Morales-García, José A.   +2 more
core   +1 more source

IAP Antagonists Selectively Eliminate Therapy-Induced Senescent Cancer Cells via TNFα-Independent Apoptosis. [PDF]

Cancer Sci
Upon chemotherapy, a subset of cancer cells enters a senescent state, referred to as TIS. When IAP antagonists are administered, TIS cells are selectively eliminated through TNFα‐independent apoptosis. TNFα secreted by TIS cancer cells may also act in a paracrine manner to enhance extrinsic apoptosis in neighboring non‐senescent cancer cells.
Ochiiwa H, Wakasa T, Kataoka Y, Ando K, Oki E, Maehara Y, Iimori M, Kitao H.   +7 more
europepmc   +2 more sources

Obesity triggers tumoral senescence and renders poorly immunogenic malignancies amenable to senolysis

Proceedings of the National Academy of Sciences, 2022
Obesity is a major risk factor for cancer. Conventional thought suggests that elevated adiposity predisposes to heightened inflammatory stress and potentiates tumor growth, yet underlying mechanisms remain ill-defined. Here, we show that tumors from patients with a body mass index >35 carry a high burden of senescent cells.
Frédérik Fournier, Roberto Diaz-Marin, Frédérique Pilon, Mathieu Neault, Rachel Juneau, Gabrielle Girouard, Ariel M. Wilson, Bruno Larrivée, Frédérick A. Mallette, Sergio Crespo-Garcia, Przemyslaw Sapieha   +10 more
openaire   +2 more sources

Identification and characterization of Cardiac Glycosides as senolytic compounds [PDF]

, 2019
Compounds with specific cytotoxic activity in senescent cells, or senolytics, support the causal involvement of senescence in aging and offer therapeutic interventions.
Arribas, Joaquín, Barradas, Marta, Bernadó, Cristina, Collado, Manuel, Da Silva-Álvarez, Sabela, Del Pino, Pablo, Domínguez, Eduardo, Fernández-Marcos, Pablo J, Ferreirós, Alba, García-Caballero, Tomás, González, Patricia, González-Barcia, Miguel, Gómez, María, Hernández-González, Fernanda, Ikonomopoulou, Maria P, Lalinde, Marta, LLanos, Susana, Loza, María I, Pedrosa, Pablo, Picallos-Rabina, Pilar, Pietrocola, Federico, Prats, Neus, Rodilla, Verónica, Serrano Marugan, Manuel, Soprano, Enrica, Triana-Martínez, Francisco, Vidal, Anxo   +26 more
core   +2 more sources