Results 71 to 80 of about 1,495 (185)

Senescent cells as a target for anti-aging interventions: From senolytics to immune therapies [PDF]

Aging and age-related diseases are major drivers of multimorbidity and mortality worldwide. Cellular senescence is a hallmark of aging. The accumulation of senescent cells is causally associated with pathogenesis of various age-associated disorders.
Fu, Tianlu Esther, Zhou, Zhongjun
core   +1 more source

Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity. [PDF]

, 2020
Pharmacologically active compounds with preferential cytotoxic activity for senescent cells, known as senolytics, can ameliorate or even revert pathological manifestations of senescence in numerous preclinical mouse disease models, including cancer ...
Bernardos, Andrea, Blandez, Juan F, Doherty, Gary J, Fruk, Ljiljana, González-Gualda, Estela, González-López, Cristina, Lozano-Torres, Beatriz, Lérida-Viso, Araceli, Macias, David, Martins, Carla P, Martínez-Máñez, Ramón, Mirón-Barroso, Sofía, Muñoz-Espín, Daniel, Ou, Hui-Ling, Pàez-Ribes, Marta, Rovira, Miguel, Sancenón, Félix, Serrano, Manuel, Wilson, Joseph R, Zhang, Zhenguang   +19 more
core   +2 more sources

Glycoprotein nonmetastatic melanoma protein B regulates lysosomal integrity and lifespan of senescent cells

Scientific Reports, 2022
Accumulation of senescent cells in various tissues has been reported to have a pathological role in age-associated diseases. Elimination of senescent cells (senolysis) was recently reported to reversibly improve pathological aging phenotypes without ...
Masayoshi Suda, Ippei Shimizu, Goro Katsuumi, Chieh Lun Hsiao, Yohko Yoshida, Naomi Matsumoto, Yutaka Yoshida, Akihiro Katayama, Jun Wada, Masahide Seki, Yutaka Suzuki, Shujiro Okuda, Kazuyuki Ozaki, Mayumi Nakanishi-Matsui, Tohru Minamino   +14 more
doaj   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

Heterogeneity in leukemia cells that escape drug-induced senescence-like state

Cell Death and Disease, 2023
Erythropoietin (EPO) suppresses drug-induced apoptosis in EPO-receptor-positive leukemia cells and allows cells to persist after drug treatment by promoting cellular senescence.
David Miller, Kyra Kerkhofs, Farnoosh Abbas-Aghababazadeh, Sahib Singh Madahar, Mark D. Minden, Josée Hébert, Benjamin Haibe-Kains, Mark A. Bayfield, Samuel Benchimol   +8 more
doaj   +1 more source

Blunting senescence boosts liver regeneration [PDF]

, 2020
The mammalian liver possesses a unique capacity for regeneration. However, this regenerative potential declines with age due to unknown mechanisms. In this issue of Genes & Development, Ritschka and colleagues (pp. 489–494).
Birch, J, Gil, J
core   +1 more source

LXR/CD38 activation drives cholesterol-induced macrophage senescence and neurodegeneration via NAD+ depletion [PDF]

Although dysregulated cholesterol metabolism predisposes aging tissues to inflammation and a plethora of diseases, the underlying molecular mechanism remains poorly defined. Here, we show that metabolic and genotoxic stresses, convergently acting through
Apte, Rajendra S, Colasanti, Jason, Du, Daniel, Hase, Keitaro, Lee, Tae Jun, Lin, Joseph B, Pfeifer, Charles W, Santeford, Andrea, Sasaki, Yo, Sohn, Brian S, Terao, Ryo, Yamaguchi, Shinobu, Yoshida, Mitsukuni   +12 more
core   +2 more sources

Aging, cellular senescence, and progressive Multiple Sclerosis [PDF]

, 2020
Aging is one of the most important risk factors for the development of several neurodegenerative diseases including progressive multiple sclerosis (MS). Cellular senescence (CS) is a key biological process underlying aging.
Gorgoulis, Vassilis G, Magliozzi, Roberta, Mitsikostas, Dimos D, Nicholas, Richard S, Papadopoulos, Dimitrios   +4 more
core   +1 more source

Multifacet Roles of Cellular Senescence in Cancer: Mechanisms and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Cellular senescence shapes tumor progression through both antitumor and protumor mechanisms. Senescence triggered by telomere shortening restricts malignant transformation and limits tumor cell proliferation, while the senescence‐associated secretory phenotype (SASP) secretion enhances antitumor immunity by activating cytotoxic T cells.
Huajie Mao, Wanning Liu, Yuanyuan Su, Yuxuan Ma, Xiaodi Zhao, Yuanyuan Lu   +5 more
wiley   +1 more source

DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss

Advanced Science, Volume 13, Issue 12, 27 February 2026.
Senescent bone marrow stromal cells accumulate in the aging bone microenvironment, promoting bone degeneration. DEL‐1, an endogenous secreted protein, acts as a natural senolytic that selectively eliminates these cells. By engaging a β3 integrin/CD73/adenosine/p38 MAPK/BCL‐2 pathway, DEL‐1 counters aging‐related bone loss, revealing promising ...
Jong‐Hyung Lim, Kridtapat Sirisereephap, Hui Wang, Giulia Trimaglio, Kyoung‐Jin Chung, Jonathan Korostoff, Tetsuhiro Kajikawa, Xiaofei Li, Meircurius D.C. Surboyo, Tomoki Maekawa, Triantafyllos Chavakis, George Hajishengallis   +11 more
wiley   +1 more source