Results 91 to 100 of about 1,495 (185)

Microvascular Health as a Key Determinant of Organismal Aging

Advanced Science, Volume 12, Issue 47, December 18, 2025.
Abstract Aging is a complex, multifaceted process affecting all organ systems, with vascular aging playing a central role in organismal health decline. Beyond its role in circulation, the vascular system acts as a dynamic interface between tissues, influencing countless physiological functions such as tissue regeneration and repair, immune responses ...
Mattia Cenciarini, Andrea Uccelli, Francesca Mangili, Myriam Grunewald, Simone Bersini   +4 more
wiley   +1 more source

Injectable microgels carrying engineered biomimetic nanoparticles for osteoarthritis therapy via dual-targeted senescent chondrocyte clearance and endogenous repair promotion

Bioactive Materials
The accumulation of senescent chondrocytes contributes significantly to osteoarthritis (OA) progression, establishing a self-perpetuating cycle of cartilage deterioration.
Peng Wang, Haiyue Zhao, Shuo Zhang, Yuhui Guo, Xin Xing, Shuai Zhou, Shuai Yang, Fengkun Wang, Wei Chen, Juan Wang, Yingze Zhang   +10 more
doaj   +1 more source

Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence

BMC Cell Biology, 2017
Background Altered expression of mRNA splicing factors occurs with ageing in vivo and is thought to be an ageing mechanism. The accumulation of senescent cells also occurs in vivo with advancing age and causes much degenerative age-related pathology ...
Eva Latorre, Vishal C. Birar, Angela N. Sheerin, J. Charles C. Jeynes, Amy Hooper, Helen R. Dawe, David Melzer, Lynne S. Cox, Richard G. A. Faragher, Elizabeth L. Ostler, Lorna W. Harries   +10 more
doaj   +1 more source

Senolysis ameliorates increased susceptibility to ventricular arrhythmias in prediabetes [PDF]

Europace
Abstract Background Obesity and associated prediabetes are major risk factors for cardiovascular disease that promote cellular senescence and predispose to ventricular arrhythmias (VA). In consequence, targeting cellular senescence may represent a feasible therapeutical approach that can decrease VA ...
Angendohr, S, Zoehner, C, Duplessis, A, Amin, E, Polzin, A, Dannenberg, L, Schmitt, J, Srivastava, T, Bejinariu, A, Rana, O, Spieker, M, Kloecker, N, Kelm, M, Gerdes, N, Lang, A   +14 more
europepmc   +2 more sources

Cdkn1a silencing restores myoblast differentiation by inducing selective apoptosis in senescent cells

Cellular & Molecular Biology Letters
Background Sarcopenia, characterized by a progressive loss of skeletal muscle mass and function, is associated with the accumulation of senescent muscle stem cells, which impair muscle regeneration and contributes to the decline in muscle health. Cdkn1a,
Sujin Kim, Bonsang Gu, Chan-Young So, Keren Esther Kristina Mantik, Seung-Hyun Jung, Sohee Moon, Dong-Ho Park, Hyo-Bum Kwak, Jinkyung Cho, Eun-Jeong Cho, Jae-Seon Lee, Ju-Hee Kang   +11 more
doaj   +1 more source

Navitoclax safety, tolerability, and effect on biomarkers of senescence and neurodegeneration in aged nonhuman primates

Heliyon
Alzheimer's disease (AD) is the most common global dementia and is universally fatal. Most late-stage AD disease-modifying therapies are intravenous and target amyloid beta (Aβ), with only modest effects on disease progression: there remains a high unmet
Edward F. Greenberg, Martin J. Voorbach, Alexandra Smith, David R. Reuter, Yuchuan Zhuang, Ji-Quan Wang, Dustin W. Wooten, Elizabeth Asque, Min Hu, Carolin Hoft, Ryan Duggan, Matthew Townsend, Karin Orsi, Karen Dalecki, Willi Amberg, Lori Duggan, Heather Knight, Joseph S. Spina, Yupeng He, Kennan Marsh, Vivian Zhao, Suzanne Ybarra, Jennifer Mollon, Yuni Fang, Aparna Vasanthakumar, Susan Westmoreland, Mathias Droescher, Sjoerd J. Finnema, Hana Florian   +28 more
doaj   +1 more source

Can senolysis be used to overcome tumor immune evasion?

Journal of Stem Cell Research & Therapeutics
Tumor escape from immunologically mediated destruction is a well-studied phenomena and has been shown to utilize several pathways in common with physiological conditions such as pregnancy, as well as ocular or testicular immune privilege. Recent interest in senescence has revealed that senescent cells surrounding tumors contribute to development of a ...
Wally Veklych, Thomas E Ichim, Robert Reznik, Vladyslav Bykoriz, Yuri Kaplun, Boris Minev, Anil Bajnath, Emma Lin, Valerii Cheshuk, Boris N Reznik   +9 more
openaire   +1 more source

A renal clearable fluorogenic probe for in vivo β-galactosidase activity detection during aging and senolysis

Nature Communications
Accumulation of senescent cells with age leads to tissue dysfunction and related diseases. Their detection in vivo still constitutes a challenge in aging research.
Sara Rojas-Vázquez, Beatriz Lozano-Torres, Alba García-Fernández, Irene Galiana, Ana Perez-Villalba, Pablo Martí-Rodrigo, M. José Palop, Marcia Domínguez, Mar Orzáez, Félix Sancenón, Juan F. Blandez, Isabel Fariñas, Ramón Martínez-Máñez   +12 more
doaj   +1 more source

Using pharmacological and proteomic analysis to investigate molecular pathways in cellular senescence [PDF]

, 2019
Upon detection of genotoxic or other stress, cells can withdraw from the cell cycle and become senescent, a fate characterized by resistance to apoptosis, organelle dysfunction and pro-inflammatory secretion.
Walters, Hannah
core   +1 more source

Unlocking the secrets of aging: Epigenetic reader BRD4 as the target to combatting aging-related diseases

Journal of Advanced Research
Background: Aging, a complex and profound journey, leads us through a labyrinth of physiological and pathological transformations, rendering us increasingly susceptible to aging-related diseases.
Jiaxing Sun, Yu Gui, Shenghua Zhou, Xi-Long Zheng   +3 more
doaj   +1 more source