Results 111 to 120 of about 1,495 (185)

A Review of Senolytic Drugs in Reducing the Biological Problems of Aging [PDF]

Sālmand
Objectives Considering the increase in the old adult population and age-related disorders, there is a need for strategies to reduce the complications of aging.
Sara Assadiasl, Sepehr Safdel, Mohammad Hossein Nicknam   +2 more
doaj  

Terpenes: natural compounds found in plants as potential senotherapeutics targeting senescent mesenchymal stromal cells and promoting apoptosis

Stem Cell Research & Therapy
Background Senescence in stem cells and progenitor cells can be particularly detrimental because these cells are essential for tissue renewal and overall organismal homeostasis.
Valeria Mazzone, Nicola Alessio, Domenico Aprile, Giovanni Galano, Roberto De Rosa, Chiara Schiraldi, Giovanni Di Bernardo, Umberto Galderisi   +7 more
doaj   +1 more source

NK‐Cell‐Derived Extracellular Vesicles Engineered to Carry Senolytics Eliminate Chemotherapy‐Induced Senescent Osteosarcoma Cells

Journal of Extracellular Vesicles
Osteosarcoma (OS) is a type of bone tumour characterized by high risk of metastatic progression and recurrence after therapy. Traditional tumour treatment methods such as radiotherapy and chemotherapy can lead to the accumulation of senescent cells in ...
Xianlin Yue, Jie Cui, Shifeng Ren, Yajun Zhang, Ying Li, Hongjuan Cui, Johnny Huard, Paul D. Robbins, Xiaodong Mu   +8 more
doaj   +1 more source

SGLT2 regulates immune-mediated senolysis

Nature Aging
Guangran Guo, Corina Amor
openaire   +2 more sources

Systemic Senolysis in Naturally Aged Mice Using a FAST-PLV Gene Therapy Approach

Abstract Approaches to eliminate senescent cells in vivo using transgenic mouse models have demonstrated significant improvements in lifespan, reduction in cancer incidence, and amelioration of age-related degeneration. These approaches require, however, that the organism be genetically engineered from the embryo and/or repeatedly dosed for the
John Lewis, Henry Garcia, Douglas Brown, Arun Raturi, Jamil Nehme, Prakash Bhandari, Ping Wee, Marco Malavolta, Liliya Grin, Hector Vega, Maria Paola Solis Ares, Jitendra Kumar, Jailal Ablack, Perrin Beatty, Gary Hudson, Matthew Sholz, Roy Duncan, Marco Demaria   +17 more
openaire   +1 more source

Immunosuppressive macrophages determine the effect of cellular senescence on tumor progression. [PDF]

Sci Adv
Lalinde-Gutiérrez M, Pérez-Ramos S, Rodilla V, Garcia-Baucells P, Perera-Bel J, Berenguer-Molins P, Nonell L, Agustí-Barea I, George C, Arribas J.   +9 more
europepmc   +1 more source

1444 Senolysis is needed for the clearance of senescent tumor cells [PDF]

Journal of Investigative Dermatology, 2018
K. Böhm, M. Röcken
openaire   +1 more source

Mitochondrial bioenergetics-SASP crosstalk determines senolytic efficacy in therapy-induced senescence. [PDF]

Cell Death Discov
Llop-Hernández À, Verdura S, López J, Martin-Castillo B, Menendez JA, Cuyàs E.   +5 more
europepmc   +1 more source

Comparative analysis of senolytic drugs reveals mitochondrial determinants of efficacy and resistance. [PDF]

Nat Aging
Wakita M, Ito K, Fujii K, Sakamoto D, Mikawa T, Sugawara S, Zhou X, Park JH, Miyagawa H, Motooka D, Ogasawara E, Ishihara N, Takahashi A, Kondoh H, Hara E.   +14 more
europepmc   +1 more source

Cellular senescence in lung cancer immune microenvironment and senotherapeutic opportunities. [PDF]

iScience
Xu Z, Liu F, Huang S, Chu Q.
europepmc   +1 more source