Results 101 to 110 of about 1,495 (185)

Dual Roles and Therapeutic Prospects of Proximal Tubular Epithelial Cell Senescence in Acute Kidney Injury

Biomolecules
Acute kidney injury (AKI), a life-threatening disorder marked by abrupt renal dysfunction, is increasingly recognized as a global healthcare challenge. It not only triggers immediate organ dysfunction but also heightens long-term risks of chronic kidney ...
Yifan Qiao, Jin Zhao, Minna Liu, Jie Liu, Qiao Zheng, Ruotong Xu, Xiaoxuan Ning, Shiren Sun, Xiangmei Chen   +8 more
doaj   +1 more source

Therapy-Induced Cellular Senescence: Potentiating Tumor Elimination or Driving Cancer Resistance and Recurrence? [PDF]

Cellular senescence has been increasingly recognized as a hallmark of cancer, reflecting its association with aging and inflammation, its role as a response to deregulated proliferation and oncogenic stress, and its induction by cancer therapies.
Kron, Stephen J., Liu, Yue, Lomeli, Isabelle   +2 more
core   +1 more source

Chaperone-mediated autophagy directs a dual mechanism to balance premature senescence and senolysis to prevent intervertebral disc degeneration

Bone Research
Intervertebral disc degeneration (IDD) is a progressive and dynamic process in which the senescence-associated secretory phenotype (SASP) of nucleus pulposus cells (NPC) plays a significant role. While impaired chaperone-mediated autophagy (CMA) has been
Zhangrong Cheng, Haiyang Gao, Pengzhi Shi, Anran Zhang, Xianglong Chen, Yuhang Chen, Weikang Gan, Kangcheng Zhao, Shuai Li, Cao Yang, Yukun Zhang   +10 more
doaj   +1 more source

Researching New Drug Combinations with Senolytic Activity Using Senescent Human Lung Fibroblasts MRC-5 Cell Line

Pharmaceuticals
Therapeutically targeting senescent cells seems to be an interesting perspective in treating chronic lung diseases, which are often associated with human aging. The combination of the drug dasatinib and the polyphenol quercetin is used in clinical trials
Maria Carolina Ximenes de Godoy, Juliana Alves Macedo, Alessandra Gambero   +2 more
doaj   +1 more source

Advances in acid-degradable and enzyme-cleavable linkers for drug delivery. [PDF]

Drug delivery vectors have the potential to improve the efficacy of therapeutics, including small molecules and nucleic acid-based drugs. However, challenges remain in developing linkages that enable the precise and efficient release of therapeutic cargo
Guo, Shutao, Han, Hesong, Murthy, Niren, Yu, Na, Zhao, Sheng   +4 more
core   +1 more source

Marizomib Promotes Senescence or Long-Term Apoptosis in Melanoma Cancer Cells

Molecules
Cellular senescence is cell cycle arrest and the inhibition of cell proliferation. New anticancer approaches include the elimination of cancer cells through the induction of senescence followed by senolysis.
Wiktoria Monika Piskorz, Rafał Krętowski, Marzanna Cechowska-Pasko   +2 more
doaj   +1 more source

Entschlüsselung des Einflusses des Spenderalters auf das renale Allograftüberleben [PDF]

Hintergrund: Die Nierentransplantation ist eine gängige Behandlung für Nierenerkrankungen im Endstadium (ESRD). Allerdings beeinflussen verschiedene immunologische Faktoren die Ergebnisse der Allotransplantation.
Sarwar, Attia
core   +1 more source

Modulating in vitro lung fibroblast activation via senolysis of senescent human alveolar epithelial cells

Aging
Idiopathic pulmonary fibrosis (IPF) is an age-related disease with poor prognosis and limited therapeutic options. Activation of lung fibroblasts and differentiation to myofibroblasts are the principal effectors of disease pathology, but damage and senescence of alveolar epithelial cells, specifically type II (ATII) cells, has recently been identified ...
Spina, Joseph S., Carr, Tracy L., Phillips, Lucy A., Knight, Heather L., Crosbie, Nancy E., Lloyd, Sarah M., Jhala, Manisha A., Lam, Tony J., Karman, Jozsef, Clements, Meghan E., Day, Tovah A., Crane, Justin D., Housley, William J.   +12 more
openaire   +2 more sources

A method to identify regulators of senolysis

Nature Aging, 2023
openaire   +2 more sources

Senescence-specific molecular subtypes stratify the hallmarks of the tumor microenvironment and guide precision medicine in bladder cancer

BMC Cancer
Background Bladder cancer (BLCA) is notably associated with advanced age, characterized by its high incidence and mortality among the elderly. Despite promising advancements in models that amalgamate molecular subtypes with treatment and prognostic ...
Luzhe Yan, Haisu Liang, Tiezheng Qi, Dingshan Deng, Jinhui Liu, Yunbo He, Jinbo Chen, Benyi Fan, Yiyan Yao, Kun Wang, Xiongbing Zu, Minfeng Chen, Yuanqing Dai, Jiao Hu   +13 more
doaj   +1 more source