Results 81 to 90 of about 1,495 (185)
Aging Cell, Volume 25, Issue 2, February 2026.Yumoto et al. show that ANGPTL2 regulates inflammation, fibrosis, and tissue remodeling in high‐fat diet‐induced premature aging. ANGPTL2 deficiency shortens lifespan but reduces inflammation, revealing its context‐dependent and organ‐specific roles in maintaining homeostasis.
Shinsei Yumoto +8 more
wiley +1 more source
Characterizing Senescence Induction and Senolytic Sensitivity in Murine Lung Cancer Cell Lines [PDF]
, 2022 While cancer patients often experience tumor reduction after receiving chemotherapy, tumors can eventually emerge from a state of dormancy. Cancer cells treated with the topoisomerase II poison, etoposide (ETO), enter senescence, which is a durable and ...
Estaleen, Rana A
core +1 more source
Aging of the Hematopoietic System: Mechanisms, Consequences, and Systemic Interactions
Aging Cell, Volume 25, Issue 2, February 2026.Hematopoietic aging arises from intrinsic stem‐cell decline and bone‐marrow niche dysfunction, leading to myeloid skewing, immunosenescence, and clonal hematopoiesis. These changes drive systemic inflammation and multi‐organ disease, which in turn further disrupt the bone‐marrow niche and hematopoietic stem cell (HSC) function, creating a vicious cycle
Masashi Miyawaki +3 more
wiley +1 more source
The Emerging Role of Senolysis in Atherosclerosis
MedicinaAtherosclerosis, a major contributor to vascular damage and plaque formation, is brought on by cellular senescence and chronic inflammation. A crucial matter that emerges is the classification of the disease in order to understand the pathogenic ...
Sylvia Vagena +10 more
doaj +1 more source
Engineering Aging: Approaches to Model and Deconstruct Biological Complexity
Advanced Materials, Volume 38, Issue 1, 2 January 2026.The macro‐experiences of aging are the result of an accumulation of micro‐changes that occur over time. Abstract The disparity between the global increase in life expectancy and the steady decline in health outcomes with age has been a major driver for developing new ways to research aging.
Habib Joukhdar +7 more
wiley +1 more source
Influence of gut microbiota on atherosclerosis [PDF]
Cardiovascular diseases (CVD) are recognized as a leading cause of death globally. Atherosclerosis, a key component of many CVDs, is a condition where plaque material builds up inside the arteries, leading to their narrowing and altered blood flow ...
Yntema, Tessa
core +4 more sources
The interplay between cell death and senescence in cancer [PDF]
Seminars in Cancer Biology.
Inuzuka, Hiroyuki +2 more
core +1 more source
THE EFFECT OF THE SENOLYTIC ABT-263 ON ANDROGEN DEPRIVATION-INDUCED SENESCENT PROSTATE TUMOR CELLS [PDF]
, 2020 Prostate cancer (PCa) is one of the leading causes of cancer-related deaths in men. Although standard treatments such as androgen deprivation therapies (ADT) and antiandrogens have increased survival for many patients, most men placed on these therapies ...
Lee, So Min
core +1 more source
Emerging Therapeutic Strategies in Anti‐Aging Medicine: A Comprehensive Review
Medicine Bulletin, Volume 2, Issue 1, Page 94-123, January 2026.ABSTRACT Aging is orchestrated by interconnected hallmarks such as genomic instability, mitochondrial dysfunction, cellular senescence, and disrupted intercellular communication, which collectively drive chronic disease progression. Recent advances have expanded therapeutic opportunities to include pharmacological agents, gene and epigenome editing ...
Yundong Peng +8 more
wiley +1 more source
Cholesterol accumulation promotes photoreceptor senescence and retinal degeneration [PDF]
PURPOSE: Dysregulated cholesterol metabolism is critical in the pathogenesis of AMD. Cellular senescence contributes to the development of numerous age-associated diseases.
Apte, Rajendra S +10 more
core +2 more sources