Results 91 to 100 of about 21,370 (250)

Mitochondrial Homeostasis and Cellular Senescence [PDF]

, 2019
Cellular senescence refers to a stress response aiming to preserve cellular and, therefore, organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic mechanisms, manifested as impaired mitochondrial biogenesis, metabolism and ...
Chronopoulos, Efstathios, Evangelou, Konstantinos, Fildisis, Georgios, Gorgoulis, Vassilis G., Havaki, Sophia, Kouloukoussa, Mirsini, Panagiotidis, Mihalis, Passias, Panagiotis-Georgios, Vasileiou, Panagiotis V.S., Vlasis, Konstantinos   +9 more
core   +1 more source

Advances in Gastric Cancer Research: Insights Into Carcinogenesis, the Tumor Microenvironment, Metastasis, and Factors Influencing Prognosis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background The Department of Gastroenterological Surgery at Kumamoto University has maintained a commitment to integrating cutting‐edge clinical practice with fundamental research, particularly concerning malignant diseases of the digestive tract.
Hideo Baba, Takatsugu Ishimoto, Yoshifumi Baba, Hiromitsu Hayashi, Masaaki Iwatsuki   +4 more
wiley   +1 more source

Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses

Aging, 2016
Senescent cells secrete senescence-associated secretory phenotype (SASP) proteins to carry out several functions, such as sensitizing surrounding cells to senesce; immunomodulation; impairing or fostering cancer growth; and promoting tissue development.
Özcan, Servet, Alessio, Nicola, Acar, Mustafa B, Mert, Eda, Omerli, Fatih, PELUSO, Gianfranco, GALDERISI, Umberto   +6 more
openaire   +4 more sources

Targeting senescence‐associated secretory phenotypes to remodel the tumour microenvironment and modulate tumour outcomes

Clinical and Translational Medicine
Tumour cell senescence can be induced by various factors, including DNA damage, inflammatory signals, genetic toxins, ionising radiation and nutrient metabolism.
Jiaqiang Xiong, Lu Dong, Qiongying Lv, Yutong Yin, Jiahui Zhao, Youning Ke, Shixuan Wang, Wei Zhang, Meng Wu   +8 more
doaj   +1 more source

Brief guide to senescence assays using cultured mammalian cells

Molecules and Cells
: Cellular senescence is a crucial biological process associated with organismal aging and many chronic diseases. Here, we present a brief guide to mammalian senescence assays, including the measurement of cell cycle arrest, change in cellular morphology,
Eunseok Kang, Chanhee Kang, Young-Sam Lee, Seung-Jae V. Lee   +3 more
doaj   +1 more source

Clearance of senescent hepatocytes in a neoplastic-prone microenvironment delays the emergence of hepatocellular carcinoma [PDF]

, 2014
Increasing evidence indicates that carcinogenesis is dependent on the tissue context in which it occurs, implying that the latter can be a target for preventive or therapeutic strategies.
Angius, F, Laconi, E, Marongiu, F, Serra, MP, Sini, M   +4 more
core   +2 more sources

Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics

Advanced Intelligent Discovery, EarlyView.
A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha, Jesus Gil, Pedro J. Ballester   +2 more
wiley   +1 more source

TREM1/3 deficiency impairs tissue repair after acute kidney injury and mitochondrial metabolic flexibility in tubular epithelial cells [PDF]

, 2019
Long-term sequelae of acute kidney injury (AKI) are associated with incomplete recovery of renal function and the development of chronic kidney disease (CKD), which can be mediated by aberrant innate immune activation, mitochondrial pathology, and ...
Borrelli, Cristiana, Butter, Loes M, Claessen, Nike, Colonna, Marco, Dessing, Mark C, Florquin, Sandrine, Leemans, Jaklien C, Rampanelli, Elena, Scantlebery, Angelique M.L, Soriani, Alessandra, Tammaro, Alessandra   +10 more
core   +2 more sources

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

Senescence and fibrosis in salivary gland aging and disease

Journal of Oral Biology and Craniofacial Research
Salivary gland hypofunction is highly prevalent in aged and diseased individuals leading to significant discomfort and morbidity. One factor that contributes to salivary gland hypofunction is cellular aging, or senescence.
Deirdre A. Nelson, Isabella Kazanjian, J. Andres Melendez, Melinda Larsen   +3 more
doaj   +1 more source