Results 91 to 100 of about 8,456,945 (252)

Senescence And The Senescence Associated Secretory Phenotype In Salivary Hypofunction [PDF]

Cellular senescence, a triggered permanent cycle arrest, occurs with aging and is a component of many aging-related diseases. Triggers for senescence may include pathways involving DNA damage, telomere dysfunction, release of reactive oxygen species, and
Jean-Baptiste, Quetsia
core   +1 more source

Fibrillarin Resists Cellular Senescence Via SIRT1‐Dependent Nicotinamide Metabolism and Its Inhibition Sensitizes Senolytic Therapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
FBL directly binds to and stabilizes SIRT1 by blocking its ubiquitin‐proteasome degradation, thereby sustaining nicotinamide metabolism and redox homeostasis to counteract cellular senescence in ESCC. Genetic and pharmacological suppression of FBL sensitizes tumor cells to senolytic therapy.
Xing Jin, Hong Liu, Ling Gao, Lei Liu, Ji‐Bin Liu, Xiaoxia Jin, Ming‐Song Wang, Dan Liu, Li Feng, Wen‐Lian Chen   +9 more
wiley   +1 more source

Brief guide to senescence assays using cultured mammalian cells

Molecules and Cells
: Cellular senescence is a crucial biological process associated with organismal aging and many chronic diseases. Here, we present a brief guide to mammalian senescence assays, including the measurement of cell cycle arrest, change in cellular morphology,
Eunseok Kang, Chanhee Kang, Young-Sam Lee, Seung-Jae V. Lee   +3 more
doaj   +1 more source

Acute phase serum amyloid A induces proinflammatory cytokines and mineralization via toll-like receptor 4 in mesenchymal stem cells

Stem Cell Research, 2015
The role of serum amyloid A (SAA) proteins, which are ligands for toll-like receptors, was analyzed in human bone marrow-derived mesenchymal stem cells (hMSCs) and their osteogenic offspring with a focus on senescence, differentiation and mineralization.
Regina Ebert, Peggy Benisch, Melanie Krug, Sabine Zeck, Jutta Meißner-Weigl, Andre Steinert, Martina Rauner, Lorenz Hofbauer, Franz Jakob   +8 more
doaj   +1 more source

RNA-binding Protein Immunoprecipitation (RIP) to Examine AUF1 Binding to Senescence-Associated Secretory Phenotype (SASP) Factor mRNA [PDF]

BIO-PROTOCOL, 2015
Immunoprecipitation and subsequent isolation of nucleic acids allows for the investigation of protein:nucleic acid interactions. RNA-binding protein immunoprecipitation (RIP) is used for the analysis of protein interactions with mRNA. Combining RIP with quantitative real-time PCR (qRT-PCR) further enhances the RIP technique by allowing for the ...
Elise Alspach, Sheila Stewart
openaire   +3 more sources

CDK4/MERCs/PINK1 Axis Drives PFOA/HFPO‐TA‐Induced Cardiac Senescence via Mitophagy Defect and cGAS‐STING Activation: In Vitro Amelioration by Cycloastragenol

Advanced Science, EarlyView.
The present study demonstrated that PFOA and HFPO‐TA exposure suppressed CDK4, disrupted MERCs and impaired PINK1/Parkin‐mediated mitophagy, thereby accelerating cardiac senescence, whereas CAG effectively reversed these pathological changes in vitro. Our findings identify CDK4 as a critical regulator bridging mitophagy defects and cardiac senescence ...
Nuo‐Wa Li, Jun‐Ze Jiang, Ying‐Ying Liu, Tian‐Tian Zhang, Kanwar Kumar Malhi, Xin Yao, Jin‐Long Li   +6 more
wiley   +1 more source

Metabolically Active but Dysfunctional: The Impact of Senescent Cells and SASP

Technology in Cancer Research & Treatment
The accumulation of senescent cells in metabolic tissues, including adipose tissue, liver, pancreas, and skeletal muscle – along with the senescence-associated secretory phenotype (SASP) has emerged as a significant factor in developing chronic ...
Kai Xu, Saatvik Viniak, Pratham Viral Shah, Ismihan Uddin, Zarqa Alam, Md Wasim Khan   +5 more
doaj   +1 more source

Molecular Regulation of SASP in Cellular Senescence: Therapeutic Implications and Translational Challenges

Cells
Cellular senescence is a complex process that significantly contributes to the pathogenesis of various diseases, including cancer and neurodegenerative disorders.
Hubert Klepacki, Krystyna Kowalczuk, Natalia Łepkowska, Justyna Magdalena Hermanowicz   +3 more
doaj   +1 more source

HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci [PDF]

, 2016
Cellular senescence is a stable cell growth arrest that is characterized by the silencing of proliferation-promoting genes through compaction of chromosomes into senescence-associated heterochromatin foci (SAHF).
Bitler B., Noma K., Tanizawa H., Le L., Kossenkov A., Zhang R., Yang T., Iwasaki O., Fatkhutdinov N., Johnson F., Aird K., Alicea G.   +11 more
core  

A Microenvironment‐Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells

Advanced Science, EarlyView.
(i) Aging impairs peripheral nerve regeneration via its dual ferroptosis‐mediated pathologies in senescent schwann cells. (ii) The composite nerve conduit is a symbiosis niche integrating microenvironment‐responsive nanoparticles (Ga‐PTAs) and maxillofacial‐derived mesenchymal stem cells (Mmscs).
Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun, Yong He, Mengfei Yu, Huiming Wang   +12 more
wiley   +1 more source