Results 111 to 120 of about 17,888 (258)

Immune Checkpoint Inhibitors Induce Intestinal Epithelial Injury and a Senescence‐Like Phenotype

iNew Medicine, EarlyView.
ICI treatment promotes the infiltration of activated immune cells into the intestinal mucosa. This inflammatory microenvironment is associated with significant epithelial injury, characterized by the disruption of the epithelial barrier, the depletion of specialized secretory cell lineages, and the induction of a premature senescence phenotype ...
Juan Wang, Shuang Wu, Shuangbiao Wei, Weizhen Xiang, Jianshang Huang, Lei Xiong, Hua Wang, Li Zuo   +7 more
wiley   +1 more source

Altered Senescence-Associated Secretory Phenotype of Human Osteoblasts from Patients with Osteoporosis Enhances Endothelial Cell Migration and Proliferation In Vitro

Biology
Osteoporosis (OP) is a highly prevalent age-associated inflammatory bone disease that remains underdiagnosed and undertreated despite its substantial global burden.
Lisa Oezel, Niklas M. Wergen, Robert Zimmermann, Simeon Popov, Beyza Gürsoy, Jan Peter Grassmann, Nele Benölken, Till Kuebart, Bernd Bittersohl, Vera Grotheer   +9 more
doaj   +1 more source

Senescence And The Senescence Associated Secretory Phenotype In Salivary Hypofunction

Cellular senescence, a triggered permanent cycle arrest, occurs with aging and is a component of many aging-related diseases. Triggers for senescence may include pathways involving DNA damage, telomere dysfunction, release of reactive oxygen species, and
Jean-Baptiste, Quetsia
core   +1 more source

Advances in Fluorescent Probes Targeting Senescence‐Associated β‐Galactosidase for Senescence Imaging

iRADIOLOGY, EarlyView.
Senescence‐associated β‐galactosidase fluorescent probes enable sensitive visualization of cellular senescence through turn‐on, ratiometric, aggregation‐induced emission‐active, and nanoprobe strategies. ABSTRACT Aging is a systemic biological process that spans multiple levels, including molecules, cells, tissues, and organs.
Jiahui Wang, Jun Wang, Shu Gao, Kun Qian, Qihang Ding, Zhen Cheng   +5 more
wiley   +1 more source

Dasatinib and quercetin prevent alveolar bone loss in aged mice

Journal of Periodontology, EarlyView.
Abstract Background Recent findings have associated alveolar bone loss (ABL) with the presence of senescent cells. Aging and the accumulation of senescent cells are associated with a pro‐inflammatory environment which may exacerbate tissue damage.
Luisa S. Battistelli, Renata M. Moraes, Yuri C. Santos, Jaqueline L. Ribeiro, Maíra T. Garcia, Renata F. Prado, Florent Elefteriou, Ana Lia Anbinder   +7 more
wiley   +1 more source

Aging and periodontitis increase brain dissemination of oral bacteria

Journal of Periodontology, EarlyView.
Abstract Background The microbiome is a dynamic system that changes throughout life. Studies have revealed the relationship between periodontal disease and the oral microbiota; however, the impact of periodontal disease on the expression of senescence markers and on the inflammaging of the oral and systemic microbiome remains unclear.
Ozge Unlu, Tsute Chen, Nil Yakar, Zeliha Guney, Bruce Paster, Isabel Carreras, Alpaslan Dedeoglu, Alpdogan Kantarci   +7 more
wiley   +1 more source

Cycloastragenol attenuates osteoarthritis by restoring chondrocyte senescence via the NRF2/NF-κB signaling axis

Scientific Reports
Osteoarthritis (OA) involves oxidative stress-induced chondrocyte senescence and extracellular matrix (ECM) dysregulation, yet disease-modifying therapies remain elusive.
Shuhao Zhang, Yanlong Zou, Jundong Long, Yufan Wang, Jian Chen, Miao Teng   +5 more
doaj   +1 more source

Osteoarthritis: An Immuno‐Inflammatory Disease‐Mechanisms of Immune Cell Dysregulation and Potential Therapeutic Strategies

Med Research, EarlyView.
This review summarizes the immuno‐inflammatory mechanisms driving the pathogenesis of osteoarthritis (OA), extending beyond the traditional view of OA as a purely degenerative disease to incorporate immune cell infiltration, inflammatory factor release, and the formation of a chronic low‐grade inflammatory microenvironment.
Qingqiang Lei, Xiaoxian Lou, Xu Su, Shubao Liu, Yanli Tong, Jie Chen, Xuerui Chen, Wenjun Mao, Hui Yu, Liangbin Lin   +9 more
wiley   +1 more source

Apoptosis signal-regulating kinase 1 promotes inflammation in senescence and aging

Communications Biology
Cellular senescence is a stress-induced, permanent cell cycle arrest involved in tumor suppression and aging. Senescent cells secrete bioactive molecules such as pro-inflammatory cytokines and chemokines.
Takeru Odawara, Shota Yamauchi, Hidenori Ichijo   +2 more
doaj   +1 more source

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

Portal Hypertension &Cirrhosis, EarlyView.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Hongcui Cao   +4 more
wiley   +1 more source