Results 101 to 110 of about 8,456,945 (252)

Impaired Chaperone‐Mediated Autophagy Accelerates Intervertebral Disc Degeneration by Inducing MIDN Accumulation to Target TSC2 for Proteasomal Degradation

Advanced Science, EarlyView.
This graphical abstract illustrates how chaperone‐mediated autophagy (CMA) regulates intervertebral disc degeneration (IDD). Under normal homeostasis (B), CMA degrades cytoplasmic Midnolin (MIDN) to maintain proteostasis. Under inflammatory stress (A), impaired CMA leads to cytoplasmic MIDN accumulation.
Xianglong Chen, Haiyang Gao, Wang Wu, Pengzhi Shi, Yuhang Chen, Anran Zhang, Zhangrong Cheng, Wenbo Wu, Zimu Yu, Yukun Zhang   +9 more
wiley   +1 more source

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype [PDF]

, 2015
Senescent cells secrete a combination of factors collectively known as the senescence-associated secretory phenotype (SASP). The SASP reinforces senescence and activates an immune surveillance response, but it can also show pro-tumorigenic properties and
Thomas, GJ, Herranz, N., Reisinger, Florian, Carroll, T, Lars Zender, Martinez-Barbera, JP, Ana Banito, Thomas, Gareth J., Hanley, Christopher J., Heikenwalder, Mathias, Georgilis, Athena, Miller, Richard A., Gopuraja Dharmalingam, Thomas, G.J., Montoya, A, Raguz, Selina, Christopher J. Hanley, Jesús Gil, Gallage, S., Dharmalingam, Gopuraja, Mathias Heikenwalder, Innes, A.J., Gill, J, Suchira Gallage, Acosta, JC, Gil, J, Banito, Ana, Gil, J., Georgilis, A., Andrew J. Innes, Thomas Carroll, Acosta, J.C., Pedro Cutillas, Sabrina Klotz, Dharmalingam, G., Klotz, S., Athena Georgilis, Juan Carlos Acosta, Juan Pedro Martínez-Barbera, Carroll, Thomas, Montoya, Alex, Zender, Lars, Hanley, CJ, Katharina Wolter, Raguz, S, Reisinger, F, Selina Raguz, Martínez-Barbera, J.P., Banito, A., Alex Montoya, Montoya, A., Banito, A, Withers, D., Heikenwalder, M, Innes, Andrew J., Reisinger, F., Gil, Jesús, Withers, Dominic, Georgilis, A, Raguz, S., Innes, AJ, Dharmalingam, G, Wuestefeld, Torsten, Wolter, Katharina, Heikenwälder, M., Martínez-Barbera, Juan Pedro, Wuestefeld, T., Wolter, K, Wuestefeld, T, Peter Faull, Zender, L., Acosta, Juan Carlos, Florian Reisinger, Gallage, S, Mellone, M, Miller, R.A., Herranz, Nicolás, Faull, P, Klotz, Sabrina, Cutillas, P, Nicolás Herranz, Wolter, K., Hanley, C.J., Cutillas, Pedro, Torsten Wuestefeld, Gareth J. Thomas, Zender, L, Faull, Peter, Klotz, S, Dominic Withers, Faull, P., Cutillas, P., Mellone, Massimiliano, Herranz, N, Carroll, T., Gallage, Suchira, Mellone, M., Miller, RA, Massimiliano Mellone, Richard A. Miller, Withers, D   +100 more
core   +2 more sources

Mitochondrial RNA cytosolic leakage drives the SASP

Nature Communications
Senescent cells secrete proinflammatory factors known as the senescence-associated secretory phenotype (SASP), contributing to tissue dysfunction and aging. Mitochondrial dysfunction is a key feature of senescence, influencing SASP via mitochondrial DNA (
Stella Victorelli, Madeline Eppard, Hélène Martini, Seung-Hwa Woo, Stacia P. A. Everts, Gung Lee, Nicholas Pirius, Nuan Han, Eugene Y. Liang, Ana Catarina Franco, Yeaeun Han, Dominik Saul, Eva Nóvoa, Rubén Nogueiras, Patrick L. Splinter, Steven P. O’Hara, Olivia Morgenthaler, Lucía Valenzuela-Pérez, Hyun Se Kim Lee, Diana Jurk, Nicholas F. LaRusso, Petra Hirsova, João F. Passos   +22 more
doaj   +1 more source

Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics

Advanced Intelligent Discovery, EarlyView.
A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha, Jesus Gil, Pedro J. Ballester   +2 more
wiley   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci

, 2020
Cellular senescence is a stable cell growth arrest that is characterized by the silencing of proliferation-promoting genes through compaction of chromosomes into senescence-associated heterochromatin foci (SAHF).
Bitler B., Noma K., Tanizawa H., Le L., Kossenkov A., Zhang R., Yang T., Iwasaki O., Fatkhutdinov N., Johnson F., Aird K., Alicea G.   +11 more
core  

The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype [PDF]

, 2019
Cellular senescence is a stress response program characterized by a robust cell cycle arrest and the induction of a proinflammatory senescence-associated secretory phenotype (SASP) that is triggered through an unknown mechanism.
Boulter, L, Fernández-Duran, Irene, Birch, Jodie, Muir, Morwenna, Millar, FR, Acosta, JC, Muir, Morwenna; id_orcid, Quintanilla, Andrea, Passos, JF, Hari, Priya, Finch, AJ, Passos, João F., Rink, CJ, Millar, Fraser R., Brunton, Valerie G., Brunton, VG, Birch, J, Quintanilla, A, Morton, Jennifer P., Muir, M, Rink, Curtis J., Hari, P, Finch, Andrew J., Acosta, Juan Carlos, Morton, JP, Tarrats, N, Tarrats, Nuria, Boulter, Luke, Fernandez-Duran, I   +28 more
core   +1 more source

The womb as the cradle of longevity: Perinatal origins of biological aging

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract The perinatal period is increasingly recognized as an important determinant of biological aging trajectories and disease susceptibility across the lifespan. This narrative review synthesizes current evidence linking intrauterine exposures to adult health outcomes across three biological dimensions: fetal programming, maternal influences, and ...
Sevim Ozge Ozdemir, Ebru Davutoglu
wiley   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Measuring the Senescence-Associated Secretory Phenotype

Cellular senescence is a fundamental hallmark of aging, contributing to tissue dysfunction and chronic disease through the senescence-associated secretory phenotype (SASP).
Maria Stangou, Achilleas Karras, Georgios Lioulios, Kantartzi, Konstantia, Lioulios, Georgios, Stangou, Maria, Konstantia Kantartzi, Asimina Fylaktou, Karras, Achilleas, Panagoutsos, Stylianos, Fylaktou, Asimina, Stylianos Panagoutsos   +11 more
core   +1 more source