Results 101 to 110 of about 10,262,985 (255)

Single‐Nucleus Transcriptomic Atlas of Human Vellus Hair Pilosebaceous Units Reveals Age‐Associated Remodeling

Advanced Science, EarlyView.
Human vellus pilosebaceous units (PSUs) remain uncharted. This single‐nucleus atlas reveals coordinated remodeling of the aging PSU niche: reduced bulge stem cell representation with altered regenerative programs, increased representation of a stress‐responsive channel+ epithelial state, enhanced androgen‐responsive sebaceous programs, reduced ...
Ya'nan Li, Zhuoqiong Qiu, Xiaoyu Pan, Geyang Xu, Shanshan Peng, Ronghui Zhu, Qiuyang Luo, Xiaokai Fang, Xu Yao, Wei Li   +9 more
wiley   +1 more source

Yoda1‐Functionalized Nanozymes Coordinate Piezo1 Activation and Mitochondrial Protection to Reprogram the Diabetic Osteoimmune Micromilieu and Promote Vascularized Bone Repair

Advanced Science, EarlyView.
Diabetic bone defects remain a critical clinical challenge. A 3D‐printed BCPG‐MF@Y scaffold, embedding Yoda1‐functionalized manganese dioxide‐ferritin nanozymes, scavenges mtROS, suppresses the cGAS–STING pathway, and reverses cellular senescence, while Yoda1 activates Piezo1 to direct BMSCs fate to synergistically reprogram the osteoimmune ...
Qing‐Song Deng, Ang Wang, Ren Zhang, Xu‐Ran Li, Po‐Lin Liu, Shu‐Hang He, Zi‐Yin Han, Zhi‐Han Shen, Zhan‐Ying Wei, Chang‐Ru Zhang, Fei Wang, Helen Dawes, Jian Lu, Tong‐He Zhu, Jin‐Zhong Zhao, Shang‐Chun Guo, Shi‐Cong Tao   +16 more
wiley   +1 more source

GDF15 is associated with hepatocellular senescence and correlates with mortality in patients with alcohol-associated hepatitis

JHEP Reports
Background & Aims: Cellular senescence is characterized by the loss of proliferative capacity, cell cycle arrest, and the acquisition of a proinflammatory senescence-associated secretory phenotype (SASP).
Teresa Rubio-Tomás, David Martí-Aguado, Delia Blaya, Silvia Ariño, Beatriz Aguilar-Bravo, Raquel A. Martínez García de la Torre, Marc Miravet-Marti, Raquel Ferrer-Lorente, Laura Zanatto, Zengqing Xu, Laura Garcia-Tercero, Carlos Mateos-Sánchez, Juan José Lozano, Isabella Dotti, Johanne Poisson, Marion Tanguy, Azucena Salas, Pierre-Emmanuel Rautou, Ramon Bataller, Pau Sancho-Bru   +19 more
doaj   +1 more source

Orthogonal Light‐ and Enzyme‐Triggered and‐Gate Prodrugs for Senolytic Therapy

Advanced Science, EarlyView.
An orthogonal AND‐gate prodrug platform combines 390 nm near‐UV photocleavage with SA‐β‐gal activation to control payload release in senescent cells. Its modular architecture enables 4‐MU fluorescence, doxorubicin‐mediated cytotoxicity, and ARV‐771‐driven BRD4 degradation, supporting stimulus‐controlled senolytic design in cellular and organoid models.
Mengyang Chang, Kaixue Zhang, Junwei Wang, Fangchao Bi, Zhuoxin Dai, Miao Yang, Ming Liu, Huanzhi Peng, Franklin Zhang, Yuan Guo, Jigang Dai, Quanxing Liu, Wei Wang   +12 more
wiley   +1 more source

Targeting the senescence-associated secretory phenotype in cancer therapy

, 2023
The current main strategy in the treatment of cancer is to target rapidly dividing cells, which induces DNA damage and promotes senescence in both cancerous and non-malignant cells alike.
Niamh Kerslake (16845207)
core   +2 more sources

Methionine restriction delays senescence and suppresses the senescence-associated secretory phenotype in the kidney through endogenous hydrogen sulfide

, 2019
Aging is a risk factor for various acute and chronic kidney injuries. Kidney aging is accompanied by the secretion of growth factors, proteases, and inflammatory cytokines, known as the senescence-associated secretory phenotype (SASP).
Si-Yang Wang (6501191), Wen-Juan Wang (403476), Yu-Huan Song (6802118), Jie-Qiong Liu (6802115), Xiang-Mei Chen (301491), Xue-Feng Sun (6802121), Ping Li (31981), Guang-Yan Cai (301489)   +7 more
core   +1 more source

A Dual‐Functional Nanoplatform Targeting the dsDNA–cGAS Axis to Mitigate Disc Degeneration and Aberrant Innervation

Advanced Science, EarlyView.
RU@PEI‐ZIF integrates dsDNA scavenging with local cGAS inhibition to suppress the dsDNA–cGAS–STING/Netrin‐1 axis in intervertebral disc degeneration. By attenuating nucleus pulposus cell senescence, inflammatory and matrix‐catabolic responses, and pathological sensory innervation, this dual‐functional nanoplatform preserves disc integrity and reduces ...
Zhaojun He, Tianyu Chen, Zezheng Liu, Xinlin Huang, Ruitangbin Jiang, Yihao Liu, Baojing Xu, Yuxiang Li, Kangning Zhao, Huibo Yan, Lei Zhou, Can Liu, Qingchu Li   +12 more
wiley   +1 more source

Senescence and Cancer: Role of Nitric Oxide (NO) in SASP

, 2020
Cellular senescence is a cell state involved in both physiological and pathological processes such as age-related diseases and cancer. While the mechanism of senescence is now well known, its role in tumorigenesis still remains very controversial.
Stéphanie Plenchette, Catherine Paul, Ali Bettaieb, Véronique Laurens, Silvia Ghione, Nesrine Mabrouk   +5 more
core   +1 more source

The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype [PDF]

, 2019
Cellular senescence is a stress response program characterized by a robust cell cycle arrest and the induction of a proinflammatory senescence-associated secretory phenotype (SASP) that is triggered through an unknown mechanism.
Boulter, L, Fernández-Duran, Irene, Birch, Jodie, Muir, Morwenna, Millar, FR, Acosta, JC, Muir, Morwenna; id_orcid, Quintanilla, Andrea, Passos, JF, Hari, Priya, Finch, AJ, Passos, João F., Rink, CJ, Millar, Fraser R., Brunton, Valerie G., Brunton, VG, Birch, J, Quintanilla, A, Morton, Jennifer P., Muir, M, Rink, Curtis J., Hari, P, Finch, Andrew J., Acosta, Juan Carlos, Morton, JP, Tarrats, N, Tarrats, Nuria, Boulter, Luke, Fernandez-Duran, I   +28 more
core   +1 more source

Mn/Zn Bimetallic MOF‐Integrated Hydrogel Alleviates Excessive Mitochondrial Fission in BMSCs to Promote Osteoporotic Jawbone Repair

Advanced Science, EarlyView.
Excessive reactive oxygen species (ROS) and chronic inflammation impair bone marrow‐derived mesenchymal stem cells (BMSCs), contributing to poor healing in osteoporotic jawbone defect. The gelatin methacryloyl hydrogel loaded with manganese‐doped zeolitic imidazolate framework (Mn‐ZIF‐8@GelMA) promotes regeneration through redox regulation and ...
Xiayue Jin, Shengjia Ye, Yun Yuan, Xueying Yang, Jiarui Cui, Hongming Zhang, Hui Huang   +6 more
wiley   +1 more source