Results 101 to 110 of about 17,888 (258)

GDF15 is associated with hepatocellular senescence and correlates with mortality in patients with alcohol-associated hepatitis

JHEP Reports
Background & Aims: Cellular senescence is characterized by the loss of proliferative capacity, cell cycle arrest, and the acquisition of a proinflammatory senescence-associated secretory phenotype (SASP).
Teresa Rubio-Tomás, David Martí-Aguado, Delia Blaya, Silvia Ariño, Beatriz Aguilar-Bravo, Raquel A. Martínez García de la Torre, Marc Miravet-Marti, Raquel Ferrer-Lorente, Laura Zanatto, Zengqing Xu, Laura Garcia-Tercero, Carlos Mateos-Sánchez, Juan José Lozano, Isabella Dotti, Johanne Poisson, Marion Tanguy, Azucena Salas, Pierre-Emmanuel Rautou, Ramon Bataller, Pau Sancho-Bru   +19 more
doaj   +1 more source

Aging and Western Diet Synergistically Impair Hepatic Thyroid Hormone Signaling to Promote Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Mice. [PDF]

Aging Cell
Aging and Western diet synergistically impair hepatic thyroid hormone signaling through decreased Dio1 and increased Dio3 activity, depleting intrahepatic T4 and T3 in senescent hepatocytes. This thyroid hormone deficit drives inflammation, fibrosis, and accelerated MASLD progression.
Zhang X, Tripathi M, Goh CT, Chan CS, Boelen A, Yen PM, Singh BK, Bruinstroop E.   +7 more
europepmc   +2 more sources

Advances in Gastric Cancer Research: Insights Into Carcinogenesis, the Tumor Microenvironment, Metastasis, and Factors Influencing Prognosis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background The Department of Gastroenterological Surgery at Kumamoto University has maintained a commitment to integrating cutting‐edge clinical practice with fundamental research, particularly concerning malignant diseases of the digestive tract.
Hideo Baba, Takatsugu Ishimoto, Yoshifumi Baba, Hiromitsu Hayashi, Masaaki Iwatsuki   +4 more
wiley   +1 more source

Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics

Advanced Intelligent Discovery, EarlyView.
A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha, Jesus Gil, Pedro J. Ballester   +2 more
wiley   +1 more source

Senescence-associated secretory phenotype in lung cancer: remodeling the tumor microenvironment for metastasis and immune suppression

Frontiers in Oncology
Cellular senescence exerts dual roles in lung cancer pathogenesis: initially suppressing tumorigenesis via p53/p21/p16-mediated cell cycle arrest, but promoting malignancy through the senescence-associated secretory phenotype (SASP).
Chen Chen, Ji Chen, Yanling Zhang, Qijun Zhang, Haixia Shi   +4 more
doaj   +1 more source

The ageing holobiont: crosstalk between telomere dynamics, oxidative stress and the gut microbiome

Biological Reviews, EarlyView.
ABSTRACT The gut tissue is at the frontline of early onset of ageing. It exhibits high cell turnover rates and rapid telomere shortening, which can have systemic effects on the developing or senescing organism. We conducted a literature review of studies on the crosstalk between telomere length dynamics, telomerase activity, oxidative stress, and gut ...
Michael L. Pepke, Søren B. Hansen, Morten T. Limborg   +2 more
wiley   +1 more source

Staring at the onco-exaptation: the two-faced medley of an ancient retrovirus, HERVH

The Journal of Clinical Investigation, 2023
Cell senescence suppresses tumors by arresting cells at risk of becoming malignant. However, this process in turn can affect the microenvironment, leading to acquisition of a senescence-associated secretory phenotype (SASP) that renders senescent cells ...
Manvendra Singh, Aleksandra M. Kondraskhina, Laurence D. Hurst, Zsuzsanna Izsvák   +3 more
doaj   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Methionine restriction delays senescence and suppresses the senescence-associated secretory phenotype in the kidney through endogenous hydrogen sulfide

, 2019
Aging is a risk factor for various acute and chronic kidney injuries. Kidney aging is accompanied by the secretion of growth factors, proteases, and inflammatory cytokines, known as the senescence-associated secretory phenotype (SASP).
Si-Yang Wang (6501191), Wen-Juan Wang (403476), Yu-Huan Song (6802118), Jie-Qiong Liu (6802115), Xiang-Mei Chen (301491), Xue-Feng Sun (6802121), Ping Li (31981), Guang-Yan Cai (301489)   +7 more
core   +1 more source

Gene expression of senescence and SASP markers in ALGS livers.

, 2023
(A) Gene expression of p21 and p16 increases in ALGS livers. (B) Gene expression of SASP markers TGF-β1, IL-6 and IL-8 is unchanged in ALGS livers. ALGS: Alagille syndrome; SASP: senescence-associated secretory phenotype. Data is presented as mean ± SD; *
Mustapha Najimi (143882), Catherine de Magnée (11086299), Roberto Tambucci (11086296), Jonathan Evraerts (511703), Giulia Jannone (8560338), Joachim Ravau (15361100), Etienne Marc Sokal (15361103)   +6 more
core   +1 more source