Targeting Senescence: A Review of Senolytics and Senomorphics in Anti-Aging Interventions [PDF]
BiomoleculesCellular senescence is a fundamental mechanism in aging, marked by irreversible growth arrest and diverse functional changes, including, but not limited to, the development of a senescence-associated secretory phenotype (SASP). While transient senescence
Timur Saliev, Prim Singh
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Proteomic and Biological Analysis of the Effects of Metformin Senomorphics on the Mesenchymal Stromal Cells [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 Senotherapeutics are new drugs that can modulate senescence phenomena within tissues and reduce the onset of age-related pathologies. Senotherapeutics are divided into senolytics and senomorphics.
Giovanni di Bernardo +2 more
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Frontiers in Nutrition, 2022 Aging is a natural physiological process, but one that poses major challenges in an increasingly aging society prone to greater health risks such as diabetes, cardiovascular disease, cancer, frailty, increased susceptibility to infection, and reduced ...
Paula Pereira, Carla Luis, Soares R
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Targeting Cellular Senescence for Healthy Aging: Advances in Senolytics and Senomorphics [PDF]
Drug Design, Development and TherapyEsther Ugo Alum,1 Sylvester Chibueze Izah,2 Daniel Ejim Uti,1 Okechukwu Paul-Chima Ugwu,1 Peter A Betiang,3 Mariam Basajja,4 Regina Idu Ejemot-Nwadiaro5 1Department of Research Publications, Kampala International University, Kampala, Uganda; 2Department ...
Sylvester Izah +2 more
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The costs and benefits of senotherapeutics for human health [PDF]
The Lancet. Healthy Longevity, 2022 Summary: Cellular senescence is a major contributor to age-related diseases in humans; however, it also has a beneficial role in physiological and pathological processes, including wound healing, host immunity, and tumour suppression. Reducing the burden
Marco Raffaele, PhD +1 more
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Advanced ScienceCellular senescence is a significant contributor to intervertebral disc aging and degeneration. However, the application of senotherapies, such as senomorphics targeting senescence markers and the senescence‐associated secretory phenotype (SASP), remains
Sheng Liu +9 more
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Distinct decidualization and senomorphic responses in endometrial vs. menstrual blood stem/stromal cells: implications for reproductive therapies [PDF]
Stem Cell Research & TherapyBackground Decidualization, the process of endometrial stem/stromal cell (EnSCs) differentiation, is essential for embryo implantation and pregnancy maintenance. Menstrual blood-derived stem/stromal cells (MenSCs), although often considered as surrogates
Negar Vanaki +7 more
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A Review of Senescence-Associated Secretory Phenotype-Mediated Remodeling of the Tumor Microenvironment: Implications for Cancer Progression and Therapy. [PDF]
Cancer Rep (Hoboken)ABSTRACT Background Cellular senescence influences cancer progression through irreversible cell‐cycle arrest, immune surveillance, and paracrine signaling mediated by the senescence‐associated secretory phenotype (SASP). SASP comprises inflammatory cytokines, chemokines, growth factors, and matrix‐remodeling enzymes that regulate the tumor ...
Pallatt S +3 more
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The Role of Cellular Senescence and SASP in the Pathogenesis of Atherosclerosis and the Therapeutic Potential of Senolytic Strategies in Cardiovascular Diseases [PDF]
BiomedicinesCellular senescence is a permanent cell cycle arrest that plays a critical role in the development and pathogenesis of age-related diseases. This paper aims to present the biological mechanisms of cellular senescence and the role of the senescence ...
Zuzanna Krupa +9 more
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The Emergence of Senescent Surface Biomarkers as Senotherapeutic Targets
Cells, 2021 Senescence is linked to a wide range of age-associated diseases and physiological declines. Thus, senotherapeutics are emerging to suppress the detrimental effects of senescence either by senomorphics or senolytics.
Martina Rossi, Kotb Abdelmohsen
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