Targeting Senescence: A Review of Senolytics and Senomorphics in Anti-Aging Interventions [PDF]
BiomoleculesCellular senescence is a fundamental mechanism in aging, marked by irreversible growth arrest and diverse functional changes, including, but not limited to, the development of a senescence-associated secretory phenotype (SASP). While transient senescence
Timur Saliev
exaly +7 more sources
Proteomic and Biological Analysis of the Effects of Metformin Senomorphics on the Mesenchymal Stromal Cells [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 Senotherapeutics are new drugs that can modulate senescence phenomena within tissues and reduce the onset of age-related pathologies. Senotherapeutics are divided into senolytics and senomorphics.
Mustafa Burak Acar, Şerife Ayaz-Guner
exaly +15 more sources
Targeting Cellular Senescence for Healthy Aging: Advances in Senolytics and Senomorphics [PDF]
Drug Design, Development and TherapyEsther Ugo Alum,1 Sylvester Chibueze Izah,2 Daniel Ejim Uti,1 Okechukwu Paul-Chima Ugwu,1 Peter A Betiang,3 Mariam Basajja,4 Regina Idu Ejemot-Nwadiaro5 1Department of Research Publications, Kampala International University, Kampala, Uganda; 2Department ...
Okechukwu Paul-Chima Ugwu +2 more
exaly +7 more sources
Frontiers in Nutrition, 2022 Aging is a natural physiological process, but one that poses major challenges in an increasingly aging society prone to greater health risks such as diabetes, cardiovascular disease, cancer, frailty, increased susceptibility to infection, and reduced ...
Carla Luis +2 more
exaly +6 more sources
Heterogeneity of Cellular Senescence, Senotyping, and Targeting by Senolytics and Senomorphics in Lung Diseases [PDF]
International Journal of Molecular SciencesCellular senescence, a state of stable cell cycle arrest accompanied by a complex senescence-associated secretory phenotype (SASP), is a fundamental biological process implicated as a key driver of lung aging and lung age-related diseases (LARDs).
Gagandeep Kaur +2 more
exaly +6 more sources
SENOLYTICS AND SENOMORPHICS: A NEW CLASS OF DRUGS FOR ANTI-AGING THERAPY
Central Asian Journal of Medical Hypotheses and EthicsAging is a complex biological process characterized by the accumulation of senescent cells that adopt a senescence-associated secretory phenotype (SASP), releasing proinflammatory mediators that drive tissue dysfunction and the onset of age-related ...
Timur Saliev
exaly +4 more sources
The costs and benefits of senotherapeutics for human health [PDF]
The Lancet. Healthy Longevity, 2022 Summary: Cellular senescence is a major contributor to age-related diseases in humans; however, it also has a beneficial role in physiological and pathological processes, including wound healing, host immunity, and tumour suppression. Reducing the burden
Marco Raffaele, PhD +1 more
doaj +3 more sources
Advanced ScienceCellular senescence is a significant contributor to intervertebral disc aging and degeneration. However, the application of senotherapies, such as senomorphics targeting senescence markers and the senescence‐associated secretory phenotype (SASP), remains
Sheng Liu +9 more
doaj +4 more sources
Senolytics and Senomorphics Targeting p38MAPK/NF-κB Pathway Protect Endothelial Cells from Oxidative Stress-Mediated Premature Senescence [PDF]
CellsOxidative stress is a prominent causal factor in the premature senescence of microvascular endothelial cells and the ensuing blood–brain barrier (BBB) dysfunction.
Ulvi Bayraktutan +2 more
exaly +4 more sources
The Role of Cellular Senescence and SASP in the Pathogenesis of Atherosclerosis and the Therapeutic Potential of Senolytic Strategies in Cardiovascular Diseases [PDF]
BiomedicinesCellular senescence is a permanent cell cycle arrest that plays a critical role in the development and pathogenesis of age-related diseases. This paper aims to present the biological mechanisms of cellular senescence and the role of the senescence ...
Zuzanna Krupa +9 more
doaj +2 more sources