Exploring New Kingdoms: The Role of Extracellular Vesicles in Oxi-Inflamm-Aging Related to Cardiorenal Syndrome [PDF]
Antioxidants, 2021 The incidence of age associated chronic diseases has increased in recent years. Although several diverse causes produce these phenomena, abundant evidence shows that oxidative stress plays a central role. In recent years, numerous studies have focused on
Cristina Mas-Bargues +4 more
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Caffeic Acid Acts as a Potent Senomorphic and Alleviates Inflammation and Lung Fibrosis by Covalently Targeting Annexin A5 Protein in Mice [PDF]
ExplorationThe accumulation of senescent cells and their secretion of senescence‐associated secretory phenotype (SASP) play important roles in the pathogenesis of idiopathic pulmonary fibrosis (IPF).
Yinhua Zhu +14 more
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Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models [PDF]
Frontiers in Aging, 2022 Increasing chronological age is the greatest risk factor for human diseases. Cellular senescence (CS), which is characterized by permanent cell-cycle arrest, has recently emerged as a fundamental mechanism in developing aging-related pathologies.
Nurcan Inci +6 more
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Lens epithelial cells senescence in cataract pathogenesis and emerging therapeutic opportunities [PDF]
Frontiers in Cell and Developmental BiologyLens epithelial cells (LECs) senescence is a central pathogenic mechanism in cataract formation, driven by a variety of chronic stressors such as oxidative damage, UV radiation, metabolic disturbances, and mechanical strain.
Liangning Cui +7 more
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SENOLYTICS AND SENOMORPHICS: A NEW CLASS OF DRUGS FOR ANTI-AGING THERAPY
Central Asian Journal of Medical Hypotheses and EthicsAging is a complex biological process characterized by the accumulation of senescent cells that adopt a senescence-associated secretory phenotype (SASP), releasing proinflammatory mediators that drive tissue dysfunction and the onset of age-related ...
Timur Saliev, Prim B. Singh
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Cellular senescence as a therapeutic target for aging intervention [PDF]
Biomedical JournalCellular senescence is a stress-induced cellular state that contributes to tissue dysfunction, chronic inflammation, and a broad range of aging-associated pathologies. The accumulation of senescent cells (SnCs) disrupt normal tissue function, positioning
Youkun Bi, Guangju Ji
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Senopathies—Diseases Associated with Cellular Senescence
Biomolecules, 2023 Cellular senescence describes a stable cell cycle arrest state with a characteristic phenotype. Senescent cells accumulate in the human body during normal aging, limiting the lifespan and promoting aging-related, but also several non-related, pathologies.
Oleh Lushchak +2 more
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Lifestyle interventions to delay senescence [PDF]
Biomedical Journal, 2023 Senescence is a condition of cell cycle arrest that increases inflammation and contributes to the development of chronic diseases in the aging human body.
Jan Martel +2 more
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Is it the time of seno-therapeutics application in cardiovascular pathological conditions related to ageing? [PDF]
Current Research in Pharmacology and Drug Discovery, 2021 It rates that in 2030, the cardiovascular diseases (CVD) will result in 40% of all deaths and rank as the leading cause. Thus, the research of appropriate therapies able to delay or retard their onset and progression is growing. Of particular interest is
Carmela Rita Balistreri +2 more
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The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related Diseases [PDF]
Biology, 2020 Cellular senescence represents a robust tumor-protecting mechanism that halts the proliferation of stressed or premalignant cells. However, this state of stable proliferative arrest is accompanied by the Senescence-Associated Secretory Phenotype (SASP ...
Lorenzo Cuollo +3 more
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