Results 11 to 20 of about 1,171 (158)

Heterogeneity of Cellular Senescence, Senotyping, and Targeting by Senolytics and Senomorphics in Lung Diseases [PDF]

International Journal of Molecular Sciences
Cellular senescence, a state of stable cell cycle arrest accompanied by a complex senescence-associated secretory phenotype (SASP), is a fundamental biological process implicated as a key driver of lung aging and lung age-related diseases (LARDs).
Irfan Rahman
exaly   +4 more sources

Zingiber officinale Roscoe Rhizome Extract Exerts Senomorphic and Anti-Inflammatory Activities on Human Endothelial Cells

Biology, 2023
Aging is related to a low-grade and sterile inflammation called inflammaging, recognized as the main risk factor for age-related disease (ARD) development.
Giulia Matacchione, Vittoria Borgonetti, Deborah Ramini, Andrea Silvestrini, Marta Ojetti, Nicoletta Galeotti, Fabiola Olivieri   +6 more
doaj   +3 more sources

SENOLYTICS AND SENOMORPHICS: A NEW CLASS OF DRUGS FOR ANTI-AGING THERAPY

Central Asian Journal of Medical Hypotheses and Ethics
Aging is a complex biological process characterized by the accumulation of senescent cells that adopt a senescence-associated secretory phenotype (SASP), releasing proinflammatory mediators that drive tissue dysfunction and the onset of age-related ...
Timur Saliev, Prim B. Singh
doaj   +2 more sources

PGC1α‐Inducing Senomorphic Nanotherapeutics Functionalized with NKG2D‐Overexpressing Cell Membranes for Intervertebral Disc Degeneration

Advanced Science
Cellular senescence is a significant contributor to intervertebral disc aging and degeneration. However, the application of senotherapies, such as senomorphics targeting senescence markers and the senescence‐associated secretory phenotype (SASP), remains
Sheng Liu, Kanglu Li, Yuxin He, Sheng Chen, Wenbo Yang, Xuanzuo Chen, Shiqing Feng, Liming Xiong, Yizhong Peng, Zengwu Shao   +9 more
doaj   +3 more sources

Cellular senescence in lung cancer immune microenvironment and senotherapeutic opportunities [PDF]

iScience
Summary: Cellular senescence (CS) shapes lung cancer biology by enforcing durable growth arrest while remodeling the tumor immune microenvironment (TIME) through the senescence-associated secretory phenotype (SASP). In non-small cell lung cancer (NSCLC),
Zhaolin Xu, Fangfang Liu, Shanshan Huang, Qian Chu   +3 more
doaj   +2 more sources

Synergistic ROS Reduction Through the Co-Inhibition of BRAF and p38 MAPK Ameliorates Senescence [PDF]

Antioxidants
Reactive oxygen species (ROS)-mediated damage to macromolecules and cellular organelles is one of the major causes of senescence. Therapeutic strategies that lower ROS levels have been proposed as important treatments for senescence, but effective ...
Myeong Uk Kuk, Duyeol Kim, Yun Haeng Lee, Jee Hee Yoon, Ji Ho Park, Yoo Jin Lee, Byeong Hyeon So, Minseon Kim, Hyung Wook Kwon, Youngjoo Byun, Joon Tae Park   +10 more
doaj   +2 more sources

From Senescent Cells to Systemic Inflammation: The Role of Inflammaging in Age-Related Diseases and Kidney Dysfunction [PDF]

Cells
Aging is characterized by a chronic, low-grade inflammatory state known as inflammaging, which closely interacts with immunosenescence—the gradual deterioration of immune function.
Federica De Luca, Valentina Camporeale, Giorgia Leccese, Roberto Cuttano, Dario Troise, Barbara Infante, Giovanni Stallone, Giuseppe Stefano Netti, Elena Ranieri   +8 more
doaj   +2 more sources

Frentizole derivatives with mTOR inhibiting and senomorphic properties [PDF]

Biomedicine & Pharmacotherapy, 2023
Frentizole is immunosuppressive drug with low acute toxicity and lifespan-prolonging effect. Recently, frentizole´s potential to disrupt toxic amyloid β (Aβ) - Aβ-binding alcohol dehydrogenase (ABAD) interaction in mitochondria in Alzheimer´s brains has been revealed.
Zofia Chrienova, David Rysanek, Josef Novak, Pavla Vasicova, Patrik Oleksak, Rudolf Andrys, Adam Skarka, Jelena Dumanovic, Zoran Milovanovic, Vesna Jacevic, Marketa Chvojkova, Kristina Holubova, Karel Vales, Veronika Skoupilova, Marian Valko, Klaudia Jomova, Suliman Y. Alomar, Fernanda D. Botelho, Tanos C.C. Franca, Kamil Kuca, Zdenek Hodny, Eugenie Nepovimova   +21 more
openaire   +4 more sources

Targeting cellular senescence with senotherapeutics: senolytics and senomorphics [PDF]

The FEBS Journal, 2022
The concept of geroscience is that since ageing is the greatest risk factor for many diseases and conditions, targeting the ageing process itself will have the greatest impact on human health. Of the hallmarks of ageing, cellular senescence has emerged as a druggable therapeutic target for extending healthspan in model organisms. Cellular senescence is
Lei Zhang, Louise E. Pitcher, Vaishali Prahalad, Laura J. Niedernhofer, Paul D. Robbins   +4 more
openaire   +2 more sources

Integrative Approaches to Treating Cellular Senescence in Kidney Disease. [PDF]

Adv Sci (Weinh)
ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Misawa T, A A, Hickson LJ, Wolfram J.
europepmc   +2 more sources