Results 21 to 30 of about 1,543 (178)
Reversing and modulating cellular senescence in beta cells, a new field of opportunities to treat diabetes [PDF]
Frontiers in Endocrinology, 2023 Diabetes constitutes a world-wide pandemic that requires searching for new treatments to halt its progression. Cellular senescence of pancreatic beta cells has been described as a major contributor to development and worsening of diabetes. The concept of
Maria F. Rubin de Celis +1 more
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Synergistic ROS Reduction Through the Co-Inhibition of BRAF and p38 MAPK Ameliorates Senescence
AntioxidantsReactive oxygen species (ROS)-mediated damage to macromolecules and cellular organelles is one of the major causes of senescence. Therapeutic strategies that lower ROS levels have been proposed as important treatments for senescence, but effective ...
Myeong Uk Kuk +10 more
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Aging and oral squamous cell carcinoma development: the role of cellular senescence [PDF]
Frontiers in Oral Health, 2023 The gradual accumulation and inadequate renewal of senescent cells over time drive organismal aging. Senescent cells undergo altered gene expression and release inflammatory mediators collectively termed the senescence-associated secretory phenotype ...
Sven Eric Niklander +3 more
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CellsCellular senescence is a complex process that significantly contributes to the pathogenesis of various diseases, including cancer and neurodegenerative disorders.
Hubert Klepacki +3 more
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Journal of RespirationCellular senescence is one of the major risk factors for the onset and progression of chronic pulmonary diseases. Cellular senescence can be induced by diverse stressors, including genotoxic damage, oncogenic signaling, and therapeutic interventions ...
Shravani Etrouth, Yin Zhu, Duo Zhang
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Cellular senescence in Alzheimer’s disease: from physiology to pathology
Translational NeurodegenerationAlzheimer’s disease (AD) is one of the most common neurodegenerative disorders, characterized by the accumulation of Aβ and abnormal tau hyperphosphorylation. Despite substantial efforts in development of drugs targeting Aβ and tau pathologies, effective
Jing Zhu, Chongyun Wu, Luodan Yang
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Frentizole derivatives with mTOR inhibiting and senomorphic properties [PDF]
Biomedicine & Pharmacotherapy, 2023 Frentizole is immunosuppressive drug with low acute toxicity and lifespan-prolonging effect. Recently, frentizole´s potential to disrupt toxic amyloid β (Aβ) - Aβ-binding alcohol dehydrogenase (ABAD) interaction in mitochondria in Alzheimer´s brains has been revealed.
Zofia Chrienova +21 more
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Targeting cellular senescence with senotherapeutics: senolytics and senomorphics [PDF]
The FEBS Journal, 2022 The concept of geroscience is that since ageing is the greatest risk factor for many diseases and conditions, targeting the ageing process itself will have the greatest impact on human health. Of the hallmarks of ageing, cellular senescence has emerged as a druggable therapeutic target for extending healthspan in model organisms. Cellular senescence is
Lei Zhang +4 more
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CellsAging is characterized by a chronic, low-grade inflammatory state known as inflammaging, which closely interacts with immunosenescence—the gradual deterioration of immune function.
Federica De Luca +8 more
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HSP90 acts as a senomorphic target in senescent retinal pigmental epithelial cells [PDF]
Aging, 2021 The senescence of retinal pigment epithelial (RPE) cells is associated with age-related macular degeneration (AMD), a leading cause of blindness in the world. HSP90 is a predominant chaperone that regulates cellular homeostasis under divergent physio-pathological conditions including senescence.
Chen, Dan-Dan +12 more
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