Exploring New Kingdoms: The Role of Extracellular Vesicles in Oxi-Inflamm-Aging Related to Cardiorenal Syndrome [PDF]
Antioxidants, 2021 The incidence of age associated chronic diseases has increased in recent years. Although several diverse causes produce these phenomena, abundant evidence shows that oxidative stress plays a central role. In recent years, numerous studies have focused on
Cristina Mas-Bargues +4 more
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The Emergence of Senescent Surface Biomarkers as Senotherapeutic Targets
Cells, 2021 Senescence is linked to a wide range of age-associated diseases and physiological declines. Thus, senotherapeutics are emerging to suppress the detrimental effects of senescence either by senomorphics or senolytics.
Martina Rossi, Kotb Abdelmohsen
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Caffeic Acid Acts as a Potent Senomorphic and Alleviates Inflammation and Lung Fibrosis by Covalently Targeting Annexin A5 Protein in Mice [PDF]
ExplorationThe accumulation of senescent cells and their secretion of senescence‐associated secretory phenotype (SASP) play important roles in the pathogenesis of idiopathic pulmonary fibrosis (IPF).
Yinhua Zhu +14 more
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Senotherapeutic Effect of Retinaldehyde and Hyaluronate Fragments in Dermatoporosis
Dermatopathology (Basel, Switzerland), 2023 Cellular senescence is one of the important mechanisms of skin aging. In a recent study, we have shown that in patients with dermatoporosis, an extreme senescence condition of the skin, cells positive for p16Ink4a, a biomarker of senescence, were ...
Jean-Hilaire Saurat +2 more
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Lens epithelial cells senescence in cataract pathogenesis and emerging therapeutic opportunities [PDF]
Frontiers in Cell and Developmental BiologyLens epithelial cells (LECs) senescence is a central pathogenic mechanism in cataract formation, driven by a variety of chronic stressors such as oxidative damage, UV radiation, metabolic disturbances, and mechanical strain.
Liangning Cui +7 more
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Cellular senescence: Molecular signatures and cellular remodeling. [PDF]
FEBS Open BioCellular senescence, a state of stable cell‐cycle arrest accompanied by profound metabolic and secretory changes, has emerged as a central hallmark of aging and a key contributor to age‐associated diseases. Despite the great progress in understanding the characteristics, the underlying molecular mechanisms, and the role of senescent cells in several ...
Kletsas D.
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Aging and oral squamous cell carcinoma development: the role of cellular senescence [PDF]
Frontiers in Oral Health, 2023 The gradual accumulation and inadequate renewal of senescent cells over time drive organismal aging. Senescent cells undergo altered gene expression and release inflammatory mediators collectively termed the senescence-associated secretory phenotype ...
Sven Eric Niklander +3 more
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Senopathies—Diseases Associated with Cellular Senescence
Biomolecules, 2023 Cellular senescence describes a stable cell cycle arrest state with a characteristic phenotype. Senescent cells accumulate in the human body during normal aging, limiting the lifespan and promoting aging-related, but also several non-related, pathologies.
Oleh Lushchak +2 more
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Translation of Cellular Senescence to Novel Therapeutics: Insights From Alternative Tools and Models [PDF]
Frontiers in Aging, 2022 Increasing chronological age is the greatest risk factor for human diseases. Cellular senescence (CS), which is characterized by permanent cell-cycle arrest, has recently emerged as a fundamental mechanism in developing aging-related pathologies.
Nurcan Inci +6 more
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Is it the time of seno-therapeutics application in cardiovascular pathological conditions related to ageing? [PDF]
Current Research in Pharmacology and Drug Discovery, 2021 It rates that in 2030, the cardiovascular diseases (CVD) will result in 40% of all deaths and rank as the leading cause. Thus, the research of appropriate therapies able to delay or retard their onset and progression is growing. Of particular interest is
Carmela Rita Balistreri +2 more
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