Results 31 to 40 of about 1,347 (176)
Senotherapeutics for Brain Aging Management [PDF]
Neurology InternationalBrain aging is a progressive process marked by cellular dysfunction, chronic inflammation, and increased susceptibility to neurodegenerative diseases.
Timur Saliev, Prim B. Singh
doaj +2 more sources
Lifestyle interventions to delay senescence [PDF]
Biomedical Journal, 2023 Senescence is a condition of cell cycle arrest that increases inflammation and contributes to the development of chronic diseases in the aging human body.
Jan Martel +2 more
doaj +3 more sources
CellsCellular senescence is a complex process that significantly contributes to the pathogenesis of various diseases, including cancer and neurodegenerative disorders.
Hubert Klepacki +3 more
doaj +2 more sources
Reversing and modulating cellular senescence in beta cells, a new field of opportunities to treat diabetes [PDF]
Frontiers in Endocrinology, 2023 Diabetes constitutes a world-wide pandemic that requires searching for new treatments to halt its progression. Cellular senescence of pancreatic beta cells has been described as a major contributor to development and worsening of diabetes. The concept of
Maria F. Rubin de Celis +1 more
doaj +2 more sources
The Senescence-Associated Secretory Phenotype (SASP) in the Challenging Future of Cancer Therapy and Age-Related Diseases [PDF]
Biology, 2020 Cellular senescence represents a robust tumor-protecting mechanism that halts the proliferation of stressed or premalignant cells. However, this state of stable proliferative arrest is accompanied by the Senescence-Associated Secretory Phenotype (SASP ...
Lorenzo Cuollo +3 more
doaj +2 more sources
Synergistic ROS Reduction Through the Co-Inhibition of BRAF and p38 MAPK Ameliorates Senescence
AntioxidantsReactive oxygen species (ROS)-mediated damage to macromolecules and cellular organelles is one of the major causes of senescence. Therapeutic strategies that lower ROS levels have been proposed as important treatments for senescence, but effective ...
Myeong Uk Kuk +10 more
doaj +2 more sources
MetabolitesChronic low back pain, a major cause of disability with a great global socioeconomic impact, has been inextricably associated with intervertebral disc degeneration.
Eleni Mavrogonatou, Dimitris Kletsas
doaj +2 more sources
Cellular senescence in Alzheimer’s disease: from physiology to pathology
Translational NeurodegenerationAlzheimer’s disease (AD) is one of the most common neurodegenerative disorders, characterized by the accumulation of Aβ and abnormal tau hyperphosphorylation. Despite substantial efforts in development of drugs targeting Aβ and tau pathologies, effective
Jing Zhu, Chongyun Wu, Luodan Yang
doaj +2 more sources
Cellular Senescence in Skeletal Muscle Aging [PDF]
Endocrinology and MetabolismCellular senescence is increasingly recognized as a pivotal mechanism driving skeletal muscle aging and the development of sarcopenia, a condition characterized by the progressive loss of muscle mass, strength, and function.
Yang Li, Huating Wang
doaj +2 more sources
Frentizole derivatives with mTOR inhibiting and senomorphic properties [PDF]
Biomedicine & Pharmacotherapy, 2023 Frentizole is immunosuppressive drug with low acute toxicity and lifespan-prolonging effect. Recently, frentizole´s potential to disrupt toxic amyloid β (Aβ) - Aβ-binding alcohol dehydrogenase (ABAD) interaction in mitochondria in Alzheimer´s brains has been revealed.
Zofia Chrienova +21 more
openaire +3 more sources