Results 31 to 40 of about 1,543 (178)
Cellular Senescence in Cardiovascular Diseases: From Pathogenesis to Therapeutic Challenges
Journal of Cardiovascular Development and Disease, 2023 Cellular senescence (CS), classically considered a stable cell cycle withdrawal, is hallmarked by a progressive decrease in cell growth, differentiation, and biological activities.
Dan Li +5 more
doaj +1 more source
Action Mechanisms of Small Extracellular Vesicles in Inflammaging
Life, 2022 The accumulation process of proinflammatory components in the body due to aging influences intercellular communication and is known as inflammaging. This biological mechanism relates the development of inflammation to the aging process.
Rocío Mato-Basalo +10 more
doaj +1 more source
Cellular senescence and the tumour microenvironment
Molecular Oncology, 2022 The senescence‐associated secretory phenotype (SASP), where senescent cells produce a variety of secreted proteins including inflammatory cytokines, chemokines, matrix remodelling factors, growth factors and so on, plays pivotal but varying roles in the ...
Masaki Takasugi +2 more
doaj +1 more source
A Senomorphic‐Conjugated Scaffold for Application of Senescent Cells in Regenerative Medicine
Advanced Therapeutics, 2023 AbstractProcuring a sufficient amount of cells is essential for cell‐based regenerative therapy. However, the application of senescent cells replicated using cell culture is limited because the cells have lost their regenerative ability or produce deleterious senescence‐associated secretory phenotypes (SASPs).
Wenqi Deng +6 more
openaire +1 more source
From genoprotection to rejuvenation
Frontiers in Bioscience-Landmark, 2020 Aging results from aberrations in signaling mechanisms and decline in biologic activities and cellular functions. Anti-aging strategies include a number of dietary, genetic, and pharmacological interventions that converge on a core network of nutrient ...
Siamak Tabibzadeh
doaj +1 more source
Senotherapeutic Effect of Retinaldehyde and Hyaluronate Fragments in Dermatoporosis
Dermatopathology, 2023 Cellular senescence is one of the important mechanisms of skin aging. In a recent study, we have shown that in patients with dermatoporosis, an extreme senescence condition of the skin, cells positive for p16Ink4a, a biomarker of senescence, were ...
Aysin Kaya +2 more
doaj +1 more source
Biology, 2023 Aging is related to a low-grade and sterile inflammation called inflammaging, recognized as the main risk factor for age-related disease (ARD) development.
Giulia Matacchione +6 more
doaj +1 more source
Senescent Cells in Cancer: Wanted or Unwanted Citizens
Cells, 2021 Over recent decades, the field of cellular senescence has attracted considerable attention due to its association with aging, the development of age-related diseases and cancer.
Sven E. Niklander +2 more
doaj +1 more source
, 2021 Senotherapeutics are new drugs that can modulate senescence phenomena within tissues and reduce the onset of age-related pathologies. Senotherapeutics are divided into senolytics and senomorphics.
Mustafa Burak Acar (11523127) +7 more
core +1 more source
, 2021 Senotherapeutics are new drugs that can modulate senescence phenomena within tissues and reduce the onset of age-related pathologies. Senotherapeutics are divided into senolytics and senomorphics.
Mustafa Burak Acar (11523127) +7 more
core +1 more source